Protocol for the challenge non-typhoidal Salmonella (CHANTS) study: a first-in-human, in-patient, double-blind, randomised, safety and dose-escalation controlled human infection model in the UK

Autor: Melita A Gordon, Christopher Smith, Xinxue Liu, Andrew J Pollard, Emma Smith, Graham S Cooke, Robert K M Choy, Anna Rydlova, Robert Varro, Jay C D Hinton, Christopher Chiu, Malick M Gibani

Publikováno v: BMJ Open, Vol 14, Iss 1 (2024)

Introduction Invasive non-typhoidal Salmonella (iNTS) serovars are a major cause of community-acquired bloodstream infections in sub-Saharan Africa (SSA). In this setting, Salmonella enterica serovar Typhimurium accounts for two-thirds of infections

Externí odkaz: https://doaj.org/article/1918efc4b7e8470281477786c25f07d8

The clinical presentation of monkeypox: a retrospective case-control study of patients with possible or probable monkeypox in a West London cohort

Autor: Stephanie Rimmer, James Barnacle, Malick M Gibani, Meng-San Wu, Oshani Dissanayake, Ravi Mehta, Trent Herdman, Mark Gilchrist, David Muir, Umar Ebrahimsa, Borja Mora-Peris, Olamide Dosekun, Lucy Garvey, Joanna Peters, Frances Davies, Graham Cooke, Aula Abbara

Publikováno v: International Journal of Infectious Diseases, Vol 126, Iss , Pp 48-53 (2023)

Objectives: Since May 2022, cases of human monkeypox virus (hMPXV) with human-to-human cross-transmission have significantly increased in nonendemic countries. Our aim was to characterize diagnostic features of patients with confirmed and possible mo

Externí odkaz: https://doaj.org/article/5a64cff3ae654e3fbb40692963999420

Molecular correlates of vaccine-induced protection against typhoid fever

Autor: Henderson Zhu, Irina Chelysheva, Deborah L. Cross, Luke Blackwell, Celina Jin, Malick M. Gibani, Elizabeth Jones, Jennifer Hill, Johannes Trück, Dominic F. Kelly, Christoph J. Blohmke, Andrew J. Pollard, Daniel O’Connor

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 16 (2023)

BACKGROUND Typhoid fever is caused by the Gram-negative bacterium Salmonella enterica serovar Typhi and poses a substantial public health burden worldwide. Vaccines have been developed based on the surface Vi-capsular polysaccharide of S. Typhi; thes

Externí odkaz: https://doaj.org/article/b81e2d3d809c4b209e52887756c00f03

Safety and immunogenicity of a two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Europe (EBOVAC2): a randomised, observer-blind, participant-blind, placebo-controlled, phase 2 trial

Autor: McShane, Christopher, Callendret, Benoit, Dincq, Stephanie, Ferrault, Camille, Chai, Siew Pin, Gyselen, Maire Paule, van Looveren, Marleen, van Ballert, Sylvia, de Cnodder, Tinne, Roza, Len, Forcheh, Chiara, Stevens, Kate, Mastrandrea, Carmela, de Ridder, Sanne, Gundluru, Rachana, Swales, Nathalie, Errijegers, Vanessa, Willems, Wouter, Roorda, Veronika, Orzabal, Nicola, Assenberg, Magdalena, Vialatte, Karine, Remblier, Frédéric, Porcar, Elodie, Ottavi, Anton, Destandau, Eugénie, Schwimmer, Christine, Moinot, Laetitia, Wallet, Cédrick, Allais, Florence, Savel, Hélène, Nedjaai, Naouel, Maugard, Anaïs, Lenzi, Nehza, Loulergue, Pierre, Bahuaud, Mathilde, Lainé, Fabrice, Laviolle, Bruno, Boissel, Nolwenn, Thébault, Elise, Vallée, David, Nicolas, Jean-François, Gilbert, Sophie, Dahel, Karima, Sagorny, Karen, Lucht, Frédéric, Paul, Stéphane, Haccourt Chanavat, Alice, Charra, Florent, Mutter, Catherine, Lambour, Monique, Muller, Caroline, Hutt-Clauss, Anne, Aranda, Olivia, Bernard, Louis, Gissot, Valérie, Hallouin-Bernard, Marie-Charlotte, Goudeau, Alain, Suzzoni, Steve, Auostin, Eva, Brick, Lysiane, Lopez-Zaragoza, Jose-Luis, Melic, Giovanna, Carvalho, Murial, Chesnel, Chrystel, Hocini, Hakim, Wiedemann, Aurélie, Hanot, Laurent, Rieux, Véronique, Puri, Adeep, Adeloye, Temitope, Boyce, Malcolm, Dennison, Jeremy, Loewenstein, Inge, Sahgal, Omar, van den Berg, Frans, Calvert, Wendy, Faldon, Mary, McClain, Bruce, Newell, Marie-Lousie, Molenberghs, Geert, Pollard, Andrew J ^*, Launay, Odile ^*, Lelievre, Jean-Daniel, Lacabaratz, Christine, Grande, Sophie, Goldstein, Neil, Robinson, Cynthia, Gaddah, Auguste, Bockstal, Viki, Wiedemann, Aurelie, Leyssen, Maarten, Luhn, Kerstin, Richert, Laura, Bétard, Christine, Gibani, Malick M, Clutterbuck, Elizabeth A, Snape, Matthew D, Levy, Yves, Douoguih, Macaya, Thiebaut, Rodolphe ^*

Publikováno v: In The Lancet Infectious Diseases April 2021 21(4):493-506

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