Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Malhowski A"'
Autor:
Deniz Toksoz, David J. Kwiatkowski, Barry L. Fanburg, Yingling Liu, Amy J. Malhowski, Geraldine A. Finlay
Supplementary Figure 1 from Selective Inhibition of Growth of Tuberous Sclerosis Complex 2–Null Cells by Atorvastatin Is Associated with Impaired Rheb and Rho GTPase Function and Reduced mTOR/S6 Kinase Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c118f0df7d182b384654647cf6a0a0
https://doi.org/10.1158/0008-5472.22370594.v1
https://doi.org/10.1158/0008-5472.22370594.v1
Autor:
Deniz Toksoz, David J. Kwiatkowski, Barry L. Fanburg, Yingling Liu, Amy J. Malhowski, Geraldine A. Finlay
Inactivating mutations in the tuberous sclerosis complex 2 (TSC2) gene, which encodes tuberin, result in the development of TSC and lymphangioleiomyomatosis (LAM). The tumor suppressor effect of tuberin lies in its GTPase-activating protein activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8072cec3f1bab399e01490310c3d0d
https://doi.org/10.1158/0008-5472.c.6496451
https://doi.org/10.1158/0008-5472.c.6496451
Autor:
Masahiro Onozawa, Ji-Eun Lee, Paula Gutierrez-Martinez, Peter D. Aplan, Amanda Day, Aysegul V. Ergen, Kai Ge, Nadia Finkel, Elsa Callen, Margarida A. Santos, Hua Tang Chen, Susan O. Sharrow, Amy Malhowski, Keisuke Ito, Scott A. Armstrong, Andres Canela, Robert B. Faryabi, André Nussenzweig, Aniruddha J. Deshpande, Derrick J. Rossi, Nancy Wong
Publikováno v:
Nature. 514:107-111
Self-renewal is the hallmark feature both of normal stem cells and cancer stem cells. Since the regenerative capacity of normal haematopoietic stem cells is limited by the accumulation of reactive oxygen species and DNA double-strand breaks, we specu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1c9d4ac78cb81a0e90e80e0b597e49
https://doi.org/10.1038/nature13483
https://doi.org/10.1038/nature13483
Autor:
Francesca Cole, Ali Alhamza, André Nussenzweig, Minxing Li, Amy Malhowski, Haiyan Zheng, Lourdes Serrano, Samuel F. Bunting, Sarah M. Misenko, Maria Jasin, Richard Baer, Dharm S Patel, Thomas Ludwig, Joonyoung Her
Publikováno v:
EMBO reports. 17(11)
BRCA1 mutations strongly predispose affected individuals to breast and ovarian cancer, but the mechanism by which BRCA1 acts as a tumor suppressor is not fully understood. Homozygous deletion of exon 2 of the mouse Brca1 gene normally causes embryoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849ca2522d4fc4a88fbdbe0c93b625de
https://pubmed.ncbi.nlm.nih.gov/27670884
https://pubmed.ncbi.nlm.nih.gov/27670884
Autor:
Mirko Völkers, Daniele Avitabile, Balaji Sundararaman, Roberto Alvarez, Zhaokang Cheng, Pearl Quijada, Mohsin Khan, Matt Mason, Christopher T. Cottage, Natalie Gude, Shabana Din, Mathias H. Konstandin, Kimberlee M. Fischer, Brandi Bailey, Amy Malhowski, Michael McGregor, Mark A. Sussman
Publikováno v:
Physiological Reviews. 91:1023-1070
One of the greatest examples of integrated signal transduction is revealed by examination of effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of multiple afferent and efferent signals, AKT exemplifies a molecular s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8994c6e49c62c2194d37fc71f938b4
https://doi.org/10.1152/physrev.00024.2010
https://doi.org/10.1152/physrev.00024.2010
Autor:
Michael S. Gilmore, Timothy C. Meredith, Tobias Bollenbach, Takashi Suzuki, Jonathan G. Swoboda, Roy Kishony, Amy J. Malhowski, Suzanne Walker, Jennifer Campbell, Stephanie Brown
Publikováno v:
ACS Chemical Biology. 4:875-883
Both Gram-positive and Gram-negative bacteria contain bactoprenol-dependent biosynthetic pathways expressing non-essential cell surface polysaccharides that function as virulence factors. Although these polymers are not required for bacterial viabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a43fa08f0910921faeac6c1d37d9f4
https://doi.org/10.1021/cb900151k
https://doi.org/10.1021/cb900151k
Publikováno v:
Journal of Bacteriology. 189:5429-5440
Using DNA microarrays, we identified 126 genes in Escherichia coli K-12 whose expression is increased at human body temperature (37°C) compared to growth at 23°C. Genes involved in the uptake and utilization of amino acids, carbohydrates, and iron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed1a2f1f4baaea4a38b08404facd354
https://doi.org/10.1128/jb.01929-06
https://doi.org/10.1128/jb.01929-06
Autor:
Barlow JH, Faryabi RB, Callxe9n E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A
Publikováno v:
Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=erc_________::59c0c43b64beeda484f2a4c6bbef9786
Akademický článek
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Autor:
Bunting SF, Callxe9n E, Kozak ML, Kim JM, Wong N, Lxf3pez-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A
Publikováno v:
Molecular Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=erc_________::993d4480212bf5ad76af927b09beee11