Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Malgorzata Milewska"'
Autor:
Sinead Toomey, Alexander J. Eustace, Joanna Fay, Katherine M. Sheehan, Aoife Carr, Malgorzata Milewska, Stephen F. Madden, Ausra Teiserskiene, Elaine W. Kay, Norma O’Donovan, William Gallagher, Liam Grogan, Oscar Breathnach, Janice Walshe, Catherine Kelly, Brian Moulton, M. John Kennedy, Guiseppe Gullo, Arnold D. Hill, Colm Power, Deirdre Duke, Niamh Hambly, John Crown, Bryan T. Hennessy
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-12 (2017)
Abstract Background The Cancer Genome Atlas analysis revealed that somatic EGFR, receptor tyrosine-protein kinase erbB-2 (ERBB2), Erb-B2 receptor tyrosine kinase 3 (ERBB3) and Erb-B2 receptor tyrosine kinase 4 (ERBB4) gene mutations (ERBB family muta
Externí odkaz:
https://doaj.org/article/2df2fd828ec74507b4f5c59ad4f1e106
Autor:
Naomi Elster, Sinead Toomey, Yue Fan, Mattia Cremona, Clare Morgan, Karolina Weiner Gorzel, Una Bhreathnach, Malgorzata Milewska, Madeline Murphy, Stephen Madden, Jarushka Naidoo, Joanna Fay, Elaine Kay, Aoife Carr, Sean Kennedy, Simon Furney, Janusz Mezynski, Oscar Breathhnach, Patrick Morris, Liam Grogan, Arnold Hill, Susan Kennedy, John Crown, William Gallagher, Bryan Hennessy, Alex Eustace
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 10 (2018)
Background: Somatic mutations in the ERBB genes (epidermal growth factor receptor: EGFR, ERBB2, ERBB3, ERBB4 ) promote oncogenesis and lapatinib resistance in metastatic HER2+ (human epidermal growth factor-like receptor 2) breast cancer in vitro . O
Externí odkaz:
https://doaj.org/article/d43fa2bc942c40b9a48533c956583447
Autor:
Malgorzata Milewska, Mattia Cremona, Clare Morgan, John O’Shea, Aoife Carr, Sri HariKrishna Vellanki, Ann M. Hopkins, Sinead Toomey, Stephen F. Madden, Bryan T. Hennessy, Alex J. Eustace
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 10 (2018)
Background: The application of genomic technologies to patient tumor samples identified groups of signaling pathways which acquire activating mutations. Some cancers are dependent on these mutations and the aberrant proteins resulting from these muta
Externí odkaz:
https://doaj.org/article/98391a82a9394b7b9a9caa7621ec1fd7
Autor:
Damien Coté, Alex Eustace, Sinead Toomey, Mattia Cremona, Malgorzata Milewska, Simon Furney, Aoife Carr, Joanna Fay, Elaine Kay, Susan Kennedy, John Crown, Bryan Hennessy, Stephen Madden
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200996 (2018)
Breast cancer is the leading cause of cancer related deaths in women worldwide and is classified into subtypes based on the cancer's receptor status. Of these subtypes, those expressing the human epidermal growth factor receptor 2 (HER2) receptor wer
Externí odkaz:
https://doaj.org/article/02a9f60a64b34945afcaf15f222ac0e7
Autor:
Malgorzata Milewska, David Romano, Ana Herrero, Maria Luisa Guerriero, Marc Birtwistle, Franz Quehenberger, Stefan Hatzl, Boris N Kholodenko, Oreste Segatto, Walter Kolch, Armin Zebisch
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129859 (2015)
BRAF functions in the RAS-extracellular signal-regulated kinase (ERK) signaling cascade. Activation of this pathway is necessary to mediate the transforming potential of oncogenic BRAF, however, it may also cause a negative feedback that inhibits the
Externí odkaz:
https://doaj.org/article/f289658d462e49cca8af4cef2c865ae6
The Core–Shell Structure, Not Sugar, Drives the Thermal Stabilization of Single-Enzyme Nanoparticles
Publikováno v:
Biomacromolecules. 22:4569-4581
Trehalose is widely assumed to be the most effective sugar for protein stabilization, but exactly how unique the structure is and the mechanism by which it works are still debated. Herein, we use a polyion complex micelle approach to control the posi
Nanogels with covalently bound and releasable trehalose for autophagy stimulation in atherosclerosis
Autor:
Yuan Zhong, Ali Maruf, Kai Qu, Małgorzata Milewska, Ilona Wandzik, Nianlian Mou, Yu Cao, Wei Wu
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Atherosclerosis, cholesterol-driven plaque formation in arteries, is a complex multicellular disease which is a leading cause of vascular diseases. During the progression of atherosclerosis, the autophagic function is impaired, resulting in
Externí odkaz:
https://doaj.org/article/84b504b4593944c4898d80276cff139b
Publikováno v:
Materials scienceengineering. C, Materials for biological applications. 119
Microfluidic technology is a powerful tool to precisely establish artificial microenvironments and has been used to generate numerous biomimetic devices. Here, we present a combined microenvironment platform, which consists of microchamber microfluid
Autor:
Nicola Cosgrove, Alex J. Eustace, Peter O’Donovan, Stephen F. Madden, Bruce Moran, John Crown, Brian Moulton, Patrick G. Morris, Liam Grogan, Oscar Breathnach, Colm Power, Michael Allen, Janice M. Walshe, Arnold D. Hill, Anna Blümel, Darren O’Connor, Sudipto Das, Małgorzata Milewska, Joanna Fay, Elaine Kay, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract HER2-positive (HER2+) breast cancer accounts for 20–25% of all breast cancers. Predictive biomarkers of neoadjuvant therapy response are needed to better identify patients with early stage disease who may benefit from tailored treatments i
Externí odkaz:
https://doaj.org/article/2aa94f4a6ce8446ea48464a6049912d0
Autor:
Stephen F. Madden, Bryan T. Hennessy, Sinead Toomey, Joyce O'Shaughnessy, Aoife Carr, John O’Shea, Naomi Elster, Alex J Eustace, Mattia Cremona, Frankie A. Holmes, Virginia Espina, Clare Morgan, Malgorzata Milewska, Lance A. Liotta
Publikováno v:
Oncotarget
// John O’Shea 1 , Mattia Cremona 1 , Clare Morgan 1 , Malgorzata Milewska 1 , Frankie Holmes 2 , Virginia Espina 3 , Lance Liotta 3 , Joyce O’Shaughnessy 4 , Sinead Toomey 1 , Stephen F. Madden 5 , Aoife Carr 1 , Naomi Elster 1 , Bryan T. Hennes