ER stress regulates alkaline phosphatase gene expression in vascular smooth muscle cells via an ATF4-dependent mechanism

Autor: Malgorzata Furmanik, Catherine M. Shanahan

Publikováno v: BMC Research Notes, Vol 11, Iss 1, Pp 1-8 (2018)

Abstract Objective Vascular calcification is the deposition of hydroxyapatite crystals in the blood vessel wall. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) plays a key role in this process. Increased expression of alkaline pho

Externí odkaz: https://doaj.org/article/a4e6cfe262af43e6957730b74866c4a2

Nicotine promotes vascular calcification via intracellular Ca2+-mediated, Nox5-induced oxidative stress, and extracellular vesicle release in vascular smooth muscle cells

Autor: Sebastian Reith, Brecht A. G. Willems, Michael J. Jacobs, Elham Bidar, Barend Mees, Ehsan Natour, Nadina Stadler, Nikolaus Marx, Malgorzata Furmanik, Mathias Burgmaier, Kathrin Burgmaier, Sylvia Heeneman, Leon J. Schurgers, Ploingarm Petsophonsakul, Florian Kahles, Chris P. M. Reutelingsperger, Felix Gremse

Publikováno v: Cardiovascular research 118(9), 2196-2210 (2022). doi:10.1093/cvr/cvab244
Cardiovascular Research, 118(9), 2196-2210. Oxford University Press

Aims Smokers are at increased risk of cardiovascular events. However, the exact mechanisms through which smoking influences cardiovascular disease resulting in accelerated atherosclerosis and vascular calcification are unknown. The aim of this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fe15d22a7eb27c9de2da9f49018679
https://doi.org/10.1093/cvr/cvab244

Reactive Oxygen-Forming Nox5 Links Vascular Smooth Muscle Cell Phenotypic Switching and Extracellular Vesicle-Mediated Vascular Calcification

Autor: Malgorzata Furmanik, Erik A.L. Biessen, Asim Cengiz Akbulut, Marie-Luce Bochaton-Piallat, Rick H. van Gorp, Guillaume J.J.M. van Eys, Chris P. M. Reutelingsperger, Ulf Hedin, Brecht A. G. Willems, Diane Proudfoot, Leon J. Schurgers, Ljubica Perisic, Harald H.H.W. Schmidt, Catherine M. Shanahan, Barend Mees, Martijn L. Chatrou

Publikováno v: Circulation Research, 127(7), 911-927. LIPPINCOTT WILLIAMS & WILKINS

Rationale: Vascular calcification, the formation of calcium phosphate crystals in the vessel wall, is mediated by vascular smooth muscle cells (VSMCs). However, the underlying molecular mechanisms remain elusive, precluding mechanism-based therapies.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cde9aba86be792b8cee8841ca3207a9
https://cris.maastrichtuniversity.nl/en/publications/6d2b25f6-9107-4d02-ad2e-fb68748635f8

Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation Involvement of Vitamin K-Dependent Processes

Autor: Michael J. Jacobs, Rachael O. Forsythe, Marc R. Dweck, Geert Willem H. Schurink, Chris P. M. Reutelingsperger, Barend Mees, Ehsan Natour, Ploingarm Petsophonsakul, Leon J. Schurgers, Malgorzata Furmanik

Publikováno v: Petsophonsakul, P, Furmanik, M, Forsythe, R, Dweck, M, Schurink, G W, Natour, E, Reutelingsperger, C, Jacobs, M, Mees, B & Schurgers, L 2019, ' Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation Involvement of Vitamin K-Dependent Processes ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 39, no. 7, pp. 1351-1368 . https://doi.org/10.1161/ATVBAHA.119.312787

Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was shown that calcification of the vessel wall is involved in both the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88b7c5d0a9f7c70c21a6c38f842771f
https://www.pure.ed.ac.uk/ws/files/108477849/ATVB_NEW_Reference_15052019.docx

MOESM1 of ER stress regulates alkaline phosphatase gene expression in vascular smooth muscle cells via an ATF4-dependent mechanism

Autor: Malgorzata Furmanik, Shanahan, Catherine

Additional file 1: Figure S1. The sequence of the ALP promoter with ER stress-related transcription factor binding sites. Figure S2. Coomassie gel used for proteomic analysis of proteins bound to the ALP promoter. Full description of materials and me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0a09bb63886dc719d927d8b04d961d