Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Malgorzata Filip"'
Autor:
Justyna Socha, Pawel Grochecki, Marta Marszalek-Grabska, Aleksandra Skrok, Irena Smaga, Tymoteusz Slowik, Wojciech Prazmo, Robert Kotlinski, Malgorzata Filip, Jolanta H. Kotlinska
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6651 (2024)
Cannabidiol (CBD), a phytocannabinoid, appeared to satisfy several criteria for a safe approach to preventing drug-taking behavior, including opioids. However, most successful preclinical and clinical results come from studies in adult males. We exam
Externí odkaz:
https://doaj.org/article/bdc8688fb3004b1e98d24a1730eebebe
Autor:
Dasiel O. Borroto-Escuela, Alexander Lopez-Salas, Karolina Wydra, Marco Bartolini, Zilong Zhou, Malgorzata Frankowska, Agata Suder, Javier Benitez-Porres, Wilber Romero-Fernandez, Malgorzata Filip, Kjell Fuxe
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Previous studies have indicated that acute treatment with the monoamine stabilizer OSU-6162 (5 mg/kg), which has a high affinity for Sigma1R, significantly increased the density of accumbal shell D2R-Sigma1R and A2AR-D2R heteroreceptor complexes foll
Externí odkaz:
https://doaj.org/article/a51533e3ab2b4ca094a860cf75cf665a
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
One of the most important yet still underappreciated mechanisms of depression is distorted cognition, with aberrant sensitivity to negative feedback being one of the best-described examples. As serotonin has been identified as an important modulator
Externí odkaz:
https://doaj.org/article/80951196b8c241e0be1236ad02d184ae
Autor:
Pawel Grochecki, Irena Smaga, Karolina Wydra, Marta Marszalek-Grabska, Tymoteusz Slowik, Ewa Kedzierska, Joanna Listos, Ewa Gibula-Tarlowska, Malgorzata Filip, Jolanta H. Kotlinska
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1941 (2023)
Treatment of Post-Traumatic Stress Disorder (PTSD) is complicated by the presence of drug use disorder comorbidity. Here, we examine whether conditioned fear (PTSD model) modifies the rewarding effect of mephedrone and if repeated mephedrone injectio
Externí odkaz:
https://doaj.org/article/cceac333be8e4ac58a13e6b89c67aff8
Autor:
Pawel Grochecki, Irena Smaga, Paulina Surowka, Marta Marszalek-Grabska, Predrag Kalaba, Vladimir Dragacevic, Patrycja Kotlinska, Malgorzata Filip, Gert Lubec, Jolanta H. Kotlinska
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10718 (2022)
Maternal separation (MS) is a key contributor to neurodevelopmental disorders, including learning disabilities. To test the hypothesis that dopamine signaling is a major factor in this, an atypical new dopamine transporter (DAT) inhibitor, CE-123, wa
Externí odkaz:
https://doaj.org/article/72726c324c1c4d7a95ee033f24472dfa
Autor:
Joanna Filarowska-Jurko, Lukasz Komsta, Irena Smaga, Paulina Surowka, Marta Marszalek-Grabska, Pawel Grochecki, Dorota Nizio, Malgorzata Filip, Jolanta H. Kotlinska
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5350 (2022)
Adverse early life experiences are associated with an enhanced risk for mental and physical health problems, including substance abuse. Despite clinical evidence, the mechanisms underlying these relationships are not fully understood. Maternal separa
Externí odkaz:
https://doaj.org/article/6cd393eb0bf24f3e94968c747a4ab822
Autor:
Pawel Grochecki, Irena Smaga, Marta Marszalek-Grabska, Malgorzata Lopatynska-Mazurek, Tymoteusz Slowik, Ewa Gibula-Tarlowska, Ewa Kedzierska, Joanna Listos, Malgorzata Filip, Jolanta H. Kotlinska
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 4, p 2122 (2022)
Mephedrone, a synthetic cathinone, is widely abused by adolescents and young adults. The aim of this study was to determine: (i) whether prior mephedrone exposure would alter ethanol reward and (ii) whether age and matrix metalloproteinase-9 (MMP-9)
Externí odkaz:
https://doaj.org/article/3cad759e9d0c465ba6f1aa06b0d51051
Autor:
Marta Marszalek-Grabska, Irena Smaga, Paulina Surowka, Pawel Grochecki, Tymoteusz Slowik, Malgorzata Filip, Jolanta H. Kotlinska
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7940 (2021)
The activation of the endocannabinoid system controls the release of many neurotransmitters involved in the brain reward pathways, including glutamate. Both endocannabinoid and glutamate systems are crucial for alcohol relapse. In the present study,
Externí odkaz:
https://doaj.org/article/d3e6b69348b841cdb807d3ae248b1fca
Autor:
Karolina Frączek, Agnieszka Kowalczyk, Martyna Pekala, Kaja Kasarello, Grażyna Sygitowicz, Dorota Sulejczak, Malgorzata Zaremba, Marek Konop, Malgorzata Frankowska, Malgorzata Filip, Magdalena Bujalska-Zadrozny, Patrycja Kleczkowska
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 29 (2020)
Recently, a well-known anti-alcohol agent, disulfiram (DSF), has gain much interest, as it was found to be effective in the treatment of cocaine abusers, thus also giving hope for patients addicted to opioids and other illicit drugs. Therefore, this
Externí odkaz:
https://doaj.org/article/2d8f52fa144240d8adde23610e2a091a
Autor:
Dasiel O. Borroto-Escuela, Karolina Wydra, Julia Pintsuk, Manuel Narvaez, Fidel Corrales, Magdalena Zaniewska, Luigi F. Agnati, Rafael Franco, Sergio Tanganelli, Luca Ferraro, Malgorzata Filip, Kjell Fuxe
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Our hypothesis is that allosteric receptor-receptor interactions in homo- and heteroreceptor complexes may form the molecular basis of learning and memory. This principle is illustrated by showing how cocaine abuse can alter the adenosine A2AR-dopami
Externí odkaz:
https://doaj.org/article/21faf16683ef49559aa3f5ce9d99b257