Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Malgorzata Czyz"'
Publikováno v:
Genes and Diseases, Vol 11, Iss 2, Pp 727-746 (2024)
Hepatocellular carcinoma (HCC) is a liver cancer, highly heterogeneous both at the histopathological and molecular levels. It arises from hepatocytes as the result of the accumulation of numerous genomic alterations in various signaling pathways, inc
Externí odkaz:
https://doaj.org/article/5a7595a8525d4da6a00d640674986538
Autor:
Michal Wozniak, Malgorzata Czyz
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Melanoma is the most lethal skin cancer with increasing incidence worldwide. Despite a great improvement of diagnostics and treatment of melanoma patients, this disease is still a serious clinical problem. Therefore, novel druggable targets are in fo
Externí odkaz:
https://doaj.org/article/fe42a52f17f749aa960b8c20ad04ffd7
Publikováno v:
Pharmaceuticals, Vol 13, Iss 8, p 194 (2020)
Primary and acquired resistance of cancer to therapy is often associated with activation of nuclear factor kappa B (NF-κB). Parthenolide (PN) has been shown to inhibit NF-κB signaling and other pro-survival signaling pathways, induce apoptosis and
Externí odkaz:
https://doaj.org/article/c49df64ce5354e35bb860cbe84b732c8
Publikováno v:
Cells, Vol 9, Iss 1, p 142 (2020)
The clinical benefit of MAPK pathway inhibition in BRAF-mutant melanoma patients is limited by the development of acquired resistance. Using drug-naïve cell lines derived from tumor specimens, we established a preclinical model of melanoma resistanc
Externí odkaz:
https://doaj.org/article/b7f9264462294f6ab57429d4ed02e5a1
Autor:
Izabela Zalesna, Marta Osrodek, Mariusz L Hartman, Michal Rozanski, Malgorzata Sztiller-Sikorska, Karolina Niewinna, Dariusz Nejc, Malgorzata Czyz
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183498 (2017)
It has been shown that the response of V600EBRAF melanoma cells to targeted therapeutics is affected by growth factors. We have investigated the influence of three different growth factors, bFGF, EGF and HGF used either alone or in combination, on th
Externí odkaz:
https://doaj.org/article/f0faec2d40b24f26bbf52d3421563266
Autor:
Markus Düchler, Liliana Czernek, Lukasz Peczek, Wojciech Cypryk, Malgorzata Sztiller-Sikorska, Malgorzata Czyz
Publikováno v:
Cells, Vol 8, Iss 7, p 665 (2019)
Background: Cancer-induced immunosuppression is antigen-specific rather than systemic and the mechanisms for the antigen specificity are incompletely understood. Here we explore the option that tumor-associated antigens (TAAs) may be transferred to a
Externí odkaz:
https://doaj.org/article/f6e5ed4e80db4280bbe5fdde7f780c45
Autor:
Malgorzata Czyz
Publikováno v:
Cells, Vol 8, Iss 6, p 540 (2019)
Fibroblast growth factor (FGF)/Fibroblast growth factor receptor (FGFR) signaling regulates various cellular processes during the embryonic development and in the adult organism. In the skin, fibroblasts and keratinocytes control proliferation and su
Externí odkaz:
https://doaj.org/article/c58982dddb31462eb4c78202e63e1293
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158275 (2016)
The heterogeneity of melanoma needs to be addressed and combination therapies seem to be necessary to overcome intrinsic and acquired resistance to newly developed immunotherapies and targeted therapies. Although the role of WNT/β-catenin pathway in
Externí odkaz:
https://doaj.org/article/158953d30d5a460d85f66c982fc1acfe
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128796 (2015)
Melanoma cells can switch their phenotypes in response to microenvironmental insults. Heterogeneous melanoma populations characterized by long-term growth and a high self-renewal capacity can be obtained in vitro in EGF(+)bFGF(+) medium whilst invasi
Externí odkaz:
https://doaj.org/article/bd8da86380814f53ad5790992923237a
Autor:
Mariusz L Hartman, Beata Talar, Muhammad Zaeem Noman, Anna Gajos-Michniewicz, Salem Chouaib, Malgorzata Czyz
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95157 (2014)
BackgroundThe diversity of functional phenotypes observed within a tumor does not exclusively result from intratumoral genetic heterogeneity but also from the response of cancer cells to the microenvironment. We have previously demonstrated that the
Externí odkaz:
https://doaj.org/article/5b1ff2f6f7964134a9bd8aa369a7e971