Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Malgorzata Czyz"'
Publikováno v:
Genes and Diseases, Vol 11, Iss 2, Pp 727-746 (2024)
Hepatocellular carcinoma (HCC) is a liver cancer, highly heterogeneous both at the histopathological and molecular levels. It arises from hepatocytes as the result of the accumulation of numerous genomic alterations in various signaling pathways, inc
Externí odkaz:
https://doaj.org/article/5a7595a8525d4da6a00d640674986538
Autor:
Michal Wozniak, Malgorzata Czyz
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Melanoma is the most lethal skin cancer with increasing incidence worldwide. Despite a great improvement of diagnostics and treatment of melanoma patients, this disease is still a serious clinical problem. Therefore, novel druggable targets are in fo
Externí odkaz:
https://doaj.org/article/fe42a52f17f749aa960b8c20ad04ffd7
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 7891
Despite significant advances in targeted therapies against the hyperactivated BRAFV600/MEK pathway for patients with unresectable metastatic melanoma, acquired resistance remains an unsolved clinical problem. In this study, we focused on melanoma cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7c39d0ffb787ef7bfc4633efd75392
Autor:
Mariusz L. Hartman, Malgorzata Czyz
Publikováno v:
Cell Death & Differentiation.
Proteins from the BCL-2 family control cell survival and apoptosis in health and disease, and regulate apoptosis-unrelated cellular processes. BCL-Gonad (BCL-G, also known as BCL2-like 14) is a non-typical protein of the family as its long isoform (B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63c4b7fece3a3518ae472f94ff01feb3
https://doi.org/10.1038/s41418-023-01158-5
https://doi.org/10.1038/s41418-023-01158-5
Publikováno v:
Genes & Diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f6c40e45c8a7efdaf9e8df577da68ae
https://doi.org/10.1016/j.gendis.2023.02.050
https://doi.org/10.1016/j.gendis.2023.02.050
Publikováno v:
Pharmaceuticals, Vol 13, Iss 8, p 194 (2020)
Primary and acquired resistance of cancer to therapy is often associated with activation of nuclear factor kappa B (NF-κB). Parthenolide (PN) has been shown to inhibit NF-κB signaling and other pro-survival signaling pathways, induce apoptosis and
Externí odkaz:
https://doaj.org/article/c49df64ce5354e35bb860cbe84b732c8
Publikováno v:
Cells, Vol 9, Iss 1, p 142 (2020)
The clinical benefit of MAPK pathway inhibition in BRAF-mutant melanoma patients is limited by the development of acquired resistance. Using drug-naïve cell lines derived from tumor specimens, we established a preclinical model of melanoma resistanc
Externí odkaz:
https://doaj.org/article/b7f9264462294f6ab57429d4ed02e5a1
Autor:
Izabela Zalesna, Marta Osrodek, Mariusz L Hartman, Michal Rozanski, Malgorzata Sztiller-Sikorska, Karolina Niewinna, Dariusz Nejc, Malgorzata Czyz
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183498 (2017)
It has been shown that the response of V600EBRAF melanoma cells to targeted therapeutics is affected by growth factors. We have investigated the influence of three different growth factors, bFGF, EGF and HGF used either alone or in combination, on th
Externí odkaz:
https://doaj.org/article/f0faec2d40b24f26bbf52d3421563266
Autor:
Joanna Bojarska, Martin Breza, Milan Remko, Malgorzata Czyz, Anna Gajos-Michniewicz, Michał Zimecki, Krzysztof Kaczmarek, Izabela D. Madura, Jakub M. Wojciechowski, Wojciech M. Wolf
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7173
Short peptides have great potential as safe and effective anticancer drug leads. Herein, the influence of short cyclic peptides containing the Pro-Pro-Phe-Phe sequence on patient-derived melanoma cells was investigated. Cyclic peptides such as cyclo(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e6fb2dd89847fdac7175f1f703177b
Autor:
Markus Düchler, Liliana Czernek, Lukasz Peczek, Wojciech Cypryk, Malgorzata Sztiller-Sikorska, Malgorzata Czyz
Publikováno v:
Cells, Vol 8, Iss 7, p 665 (2019)
Background: Cancer-induced immunosuppression is antigen-specific rather than systemic and the mechanisms for the antigen specificity are incompletely understood. Here we explore the option that tumor-associated antigens (TAAs) may be transferred to a
Externí odkaz:
https://doaj.org/article/f6e5ed4e80db4280bbe5fdde7f780c45