Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Malgorzata Broncel"'
Autor:
Alex W Chan, Malgorzata Broncel, Eden Yifrach, Nicole R Haseley, Sundeep Chakladar, Elena Andree, Alice L Herneisen, Emily Shortt, Moritz Treeck, Sebastian Lourido
Publikováno v:
eLife, Vol 12 (2023)
Apicomplexan parasites use Ca2+-regulated exocytosis to secrete essential virulence factors from specialized organelles called micronemes. Ca2+-dependent protein kinases (CDPKs) are required for microneme exocytosis; however, the molecular events tha
Externí odkaz:
https://doaj.org/article/cdceeb18a7dc4dd7aab8d093acc13d96
Publikováno v:
eLife, Vol 12 (2023)
Reverse genetics is key to understanding protein function, but the mechanistic connection between a gene of interest and the observed phenotype is not always clear. Here we describe the use of proximity labeling using TurboID and site-specific quanti
Externí odkaz:
https://doaj.org/article/2fa65852f6644f1aa3849d66a75a9b35
Autor:
Simon Butterworth, Francesca Torelli, Eloise J Lockyer, Jeanette Wagener, Ok-Ryul Song, Malgorzata Broncel, Matt R G Russell, Aline Cristina A Moreira-Souza, Joanna C Young, Moritz Treeck
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1011021 (2022)
Toxoplasma gondii is an intracellular parasite that can infect many host species and is a cause of significant human morbidity worldwide. T. gondii secretes a diverse array of effector proteins into the host cell which are critical for infection. The
Externí odkaz:
https://doaj.org/article/1ef7567a322246b68d3ab5f125e50e7c
Autor:
Stephanie D Nofal, Caia Dominicus, Malgorzata Broncel, Nicholas J Katris, Helen R Flynn, Gustavo Arrizabalaga, Cyrille Y Botté, Brandon M Invergo, Moritz Treeck
Publikováno v:
PLoS Pathogens, Vol 18, Iss 10, p e1010901 (2022)
Fundamental processes that govern the lytic cycle of the intracellular parasite Toxoplasma gondii are regulated by several signalling pathways. However, how these pathways are connected remains largely unknown. Here, we compare the phospho-signalling
Externí odkaz:
https://doaj.org/article/f1bcfcff899b4410afe264cbf598c595
Autor:
Maria Giorgalli, Deirdre A. Cunningham, Malgorzata Broncel, Aaron Sait, Thomas E. Harrison, Caroline Hosking, Audrey Vandomme, Sarah I. Amis, Ana Antonello, Lauren Sullivan, Faith Uwadiae, Laura Torella, Matthew K. Higgins, Jean Langhorne
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Plasmodium multigene families are thought to play important roles in the pathogenesis of malaria. Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium species. However, their expression pattern and local
Externí odkaz:
https://doaj.org/article/fdfc5059f3df4ec5b76c252da4225093
Autor:
Joanna C. Young, Malgorzata Broncel, Helena Teague, Matt R. G. Russell, Olivia L. McGovern, Matt Renshaw, David Frith, Ambrosius P. Snijders, Lucy Collinson, Vern B. Carruthers, Sarah E. Ewald, Moritz Treeck
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT The intracellular parasite Toxoplasma gondii resides within a membrane-bound parasitophorous vacuole (PV) and secretes an array of proteins to establish this replicative niche. It has been shown previously that Toxoplasma secretes kinases an
Externí odkaz:
https://doaj.org/article/8ec188a235d64c0fb4aaa3600be59d6f
Autor:
Malgorzata Broncel, Caia Dominicus, Luis Vigetti, Stephanie D Nofal, Edward J Bartlett, Bastien Touquet, Alex Hunt, Bethan A Wallbank, Stefania Federico, Stephen Matthews, Joanna C Young, Edward W Tate, Isabelle Tardieux, Moritz Treeck
Publikováno v:
eLife, Vol 9 (2020)
N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens. Myristoylation often primes for subsequent palmitoylation and stable
Externí odkaz:
https://doaj.org/article/4aae0298b361407f832a724979434ba2
Autor:
Kristin Folmert, Malgorzata Broncel, Hans v. Berlepsch, Christopher H. Ullrich, Mary-Ann Siegert, Beate Koksch
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 2462-2470 (2016)
As is the case in numerous natural processes, enzymatic phosphorylation can be used in the laboratory to influence the conformational populations of proteins. In nature, this information is used for signal transduction or energy transfer, but has als
Externí odkaz:
https://doaj.org/article/3c6372adf1f24f6baf86709258a3c23c
Autor:
Jocelyn P. Wong, Jason R. Todd, Martina A. Finetti, Frank McCarthy, Malgorzata Broncel, Simon Vyse, Maciej T. Luczynski, Stephen Crosier, Karen A. Ryall, Kate Holmes, Leo S. Payne, Frances Daley, Patty Wai, Andrew Jenks, Barbara Tanos, Aik-Choon Tan, Rachael C. Natrajan, Daniel Williamson, Paul H. Huang
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1265-1275 (2016)
Summary: Subunits of the SWI/SNF chromatin remodeling complex are mutated in a significant proportion of human cancers. Malignant rhabdoid tumors (MRTs) are lethal pediatric cancers characterized by a deficiency in the SWI/SNF subunit SMARCB1. Here,
Externí odkaz:
https://doaj.org/article/1ea3b596e8cc4e36bc647eff1eeb7332
Autor:
Malgorzata Broncel, Remigiusz A Serwa, Paulina Ciepla, Eberhard Krause, Margaret J. Dallman, Anthony I. Magee, Edward W. Tate
Publikováno v:
Data in Brief, Vol 4, Iss C, Pp 379-383 (2015)
Human cells (HEK 293, HeLa, MCF-7) and zebrafish embryos were metabolically tagged with an alkynyl myristic acid probe, lysed with an SDS buffer and tagged proteomes ligated to multifunctional capture reagents via copper-catalyzed alkyne azide cycloa
Externí odkaz:
https://doaj.org/article/b46e0e25d4cc47ae80460e01c7a10398