Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Malgorzata Balinska"'
Publikováno v:
Journal of Biological Chemistry. 275:13012-13016
Folylpolyglutamate synthetase (FPGS) activity in CCRF-CEM human leukemia cells was found in the cytosolic (≈67% of total) and mitochondrial (≈22%) fractions. A polyclonal antipeptide antibody (430Ab) to human FPGS specifically recognized distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7079b9eb55ff63dca976c50b1428697
https://doi.org/10.1074/jbc.275.17.13012
https://doi.org/10.1074/jbc.275.17.13012
Publikováno v:
Archives of biochemistry and biophysics. 284(1)
Reduced derivatives of 10-formylfolate have been evaluated as inhibitors of mammalian thymidylate synthase (EC 2.1.1.45) from H35 hepatoma cells. With 5,10-methylenetetrahydrofolylheptaglutamate as the substrate, 10-formyltetrahydrofolylmonoglutamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6567d6a5465c5b536f32c915a6c8b6b4
https://pubmed.ncbi.nlm.nih.gov/1989499
https://pubmed.ncbi.nlm.nih.gov/1989499
Publikováno v:
Cancer Letters. 30:79-84
H35 hepatoma cells can be rescued from exposure to an inhibitory pulse of methotrexate (MTX) by subsequent addition of folinic acid, dihydrofolate or thymidine. Both folinic acid and dihydrofolate cause the dissociation of methotrexate--dihydrofolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e069e089201d79a7fad2abc10810f0
https://doi.org/10.1016/0304-3835(86)90135-7
https://doi.org/10.1016/0304-3835(86)90135-7
Publikováno v:
Archives of Biochemistry and Biophysics. 216:466-476
Upon exposure of primary monolayer cultures of hepatocytes and H35 hepatoma cells, methptrexate (MTX) is taken up by carrier-mediated mechanisms and converted to γ-glutamyl derivatives with one to four residues being added. Under conditions that res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5434e884f1da99b36ecc75cbfdddb42
https://doi.org/10.1016/0003-9861(82)90235-1
https://doi.org/10.1016/0003-9861(82)90235-1
Publikováno v:
Biochemical Pharmacology. 32:3244-3247
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3fc56a00816f911d74ca51df0eba2c
https://doi.org/10.1016/0006-2952(83)90211-3
https://doi.org/10.1016/0006-2952(83)90211-3
Publikováno v:
Advances in Enzyme Regulation. 20:111-121
The polyglutamate metabolites of methotrexate are as inhibitory to the target enzyme dihydrofolate reductase as is methotrexate. Because of their greater retention they have a longer half-life within the cells and thus a greater potential for cytotox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4e025988137679ae4d552ccd4a153b
https://doi.org/10.1016/0065-2571(82)90011-5
https://doi.org/10.1016/0065-2571(82)90011-5
Publikováno v:
St. Andrews, Scotland, September 21-24, 1982
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5661ac88ce6dc2830c2bb1d5f987d93
https://doi.org/10.1515/9783111619453.921
https://doi.org/10.1515/9783111619453.921
Autor:
Malgorzata Balinska, John Galivan
Publikováno v:
St. Andrews, Scotland, September 21-24, 1982
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fa7f74e5c4ade2faf085c318e0aedee
https://doi.org/10.1515/9783111619453.305
https://doi.org/10.1515/9783111619453.305
Autor:
John Galivan, Malgorzata Balinska
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781475752434
Methotrexate polyglutamates are extensively synthesized when cultured hepatocytes and H35 hepatoma cells are exposed to micro-molar concentrations of methotrexate. The predominant species found within the cell have from two to four additional γ-link
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dae5da7962c3294fdc528d82386e5ac4
https://doi.org/10.1007/978-1-4757-5241-0_18
https://doi.org/10.1007/978-1-4757-5241-0_18
Publikováno v:
Biochimica et biophysica acta. 721(3)
A brief treatment of H35 hepatoma cells with lysolecithin resulted in a cell population which is permeable to low-molecular weight charged molecules that cannot normally cross the plasma membrane. These include deoxynucleotide and nucleotide triphosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b4584cff935063dad67b5169e3ea84
https://pubmed.ncbi.nlm.nih.gov/7171628
https://pubmed.ncbi.nlm.nih.gov/7171628