Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer

Autor: Clemens Hinterleitner, Jasmin Strähle, Elke Malenke, Martina Hinterleitner, Melanie Henning, Marco Seehawer, Tatjana Bilich, Jonas Heitmann, Martina Lutz, Sven Mattern, Sophia Scheuermann, Marius Horger, Stefanie Maurer, Juliane Walz, Falko Fend, Rupert Handgretinger, Christian Seitz, Bettina Weigelin, Stephan Singer, Helmut Salih, Oliver Borst, Hans-Georg Kopp, Lars Zender

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

The definition of biomarkers to predict therapy responses to immune-checkpoint inhibitors represent an unmet clinical need. Here the authors provide evidences that platelet-derived PD-L1 could serve as a prognostic and predictive biomarker in patient

Externí odkaz: https://doaj.org/article/667bac11196140cc814118dc5b22f2f3

Bispecific NKG2D-CD3 and NKG2D-CD16 Fusion Proteins as Novel Treatment Option in Advanced Soft Tissue Sarcomas

Autor: Ilona Hagelstein, Martina S. Lutz, Moritz Schmidt, Jonas S. Heitmann, Elke Malenke, Yanjun Zhou, Kim L. Clar, Hans-Georg Kopp, Gundram Jung, Helmut R. Salih, Melanie Märklin, Clemens Hinterleitner

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Soft tissue sarcoma (STS) constitutes a rare group of heterogeneous malignancies. Effective treatment options for most subtypes of STS are still limited. As a result, especially in metastatic disease, prognosis is still dismal. The ligands for the ac

Externí odkaz: https://doaj.org/article/c983352f25e8461eb8b95d844f20a749

Intraosseous hemangioma of the orbit: a case report involving pre-operative embolization with reconstruction using a custom porous polyethylene implant

Autor: Adrianna E. Eder, Sarah A. Avila, Jordan Malenke, John M. Del Gaudio, Ted Wojno

Publikováno v: Orbit. :1-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7620bdd863ca9b4a8824807c5daa7e40
https://doi.org/10.1080/01676830.2023.2192778

International consensus statement on allergy and rhinology:Allergic rhinitis - 2023

Autor: Sarah K. Wise, Cecelia Damask, Lauren T. Roland, Charles Ebert, Joshua M. Levy, Sandra Lin, Amber Luong, Kenneth Rodriguez, Ahmad R. Sedaghat, Elina Toskala, Jennifer Villwock, Baharudin Abdullah, Cezmi Akdis, Jeremiah A. Alt, Ignacio J. Ansotegui, Antoine Azar, Fuad Baroody, Michael S. Benninger, Jonathan Bernstein, Christopher Brook, Raewyn Campbell, Thomas Casale, Mohamad Chaaban, Fook Tim Chew, Jeffrey Chambliss, Antonella Cianferoni, Adnan Custovic, Elizabeth Mahoney Davis, John M. DelGaudio, Anne K. Ellis, Carrie Flanagan, Wytske J. Fokkens, Christine Franzese, Matthew Greenhawt, Amarbir Gill, Ashleigh Halderman, Jens M. Hohlfeld, Cristoforo Incorvaia, Stephanie A. Joe, Shyam Joshi, Merin Elizabeth Kuruvilla, Jean Kim, Adam M. Klein, Helene J. Krouse, Edward C. Kuan, David Lang, Desiree Larenas‐Linnemann, Adrienne M. Laury, Matt Lechner, Stella E. Lee, Victoria S. Lee, Patricia Loftus, Sonya Marcus, Haidy Marzouk, Jose Mattos, Edward McCoul, Erik Melen, James W. Mims, Joaquim Mullol, Jayakar V. Nayak, John Oppenheimer, Richard R. Orlandi, Katie Phillips, Michael Platt, Murugappan Ramanathan, Mallory Raymond, Chae‐Seo Rhee, Sietze Reitsma, Matthew Ryan, Joaquin Sastre, Rodney J. Schlosser, Theodore A. Schuman, Marcus S. Shaker, Aziz Sheikh, Kristine A. Smith, Michael B. Soyka, Masayoshi Takashima, Monica Tang, Pongsakorn Tantilipikorn, Malcolm B. Taw, Jody Tversky, Matthew A. Tyler, Maria C. Veling, Dana Wallace, De Yun Wang, Andrew White, Luo Zhang, Omar G. Ahmed, Khashayar Arianpour, Emily Barrow, Carlo Cavaliere, Juan Carlos Ceballos Cantu, Mark B. Chaskes, Andy Jian Kai Chua, Srihari Daggumati, Luke Daines, Paul Daraei, Thomas Edwards, Deanna Gigliotti, Mitchell Gore, Khodayar Goshtasbi, Doo Hee Han, Lubnaa Hossenbaccus, Megan Jolicoeur, Dichapong Kanjanawasee, Suat Kilic, Sophia Linton, David Liu, Christoper Low, Chengetai Mahomva, Jordan A. Malenke, Amar Miglani, Peter Nagy, Jin‐A Park, Marianella Paz‐Lansberg, Paul Pfeffer, Marisa Ryan, Anirudh Saraswathula, Cameron Sheehan, Nadja Struss, Kevin Tie, Sina Torabi, Esmond F. Tsai, Nathalia Velasquez, Jackson Vuncannon, Duncan Watley, Xinni Xu

Publikováno v: Wise, S K, Damask, C, Roland, L T, Ebert, C, Levy, J M, Lin, S, Luong, A, Rodriguez, K, Sedaghat, A R, Toskala, E, Villwock, J, Abdullah, B, Akdis, C, Alt, J A, Ansotegui, I J, Azar, A, Baroody, F, Benninger, M S, Bernstein, J, Brook, C, Campbell, R, Casale, T, Chaaban, M, Chew, F T, Chambliss, J, Cianferoni, A, Custovic, A, Davis, E M, DelGaudio, J M, Ellis, A K, Flanagan, C, Fokkens, W J, Franzese, C, Greenhawt, M, Gill, A, Halderman, A, Hohlfeld, J M, Incorvaia, C, Joe, S A, Joshi, S, Kuruvilla, M E, Kim, J, Klein, A M, Krouse, H J, Kuan, E C, Lang, D, Larenas-Linnemann, D, Laury, A M, Lechner, M, Lee, S E, Lee, V S, Loftus, P, Marcus, S, Marzouk, H, Mattos, J, McCoul, E, Melen, E, Mims, J W, Mullol, J, Nayak, J V, Oppenheimer, J, Orlandi, R R, Phillips, K, Platt, M, Ramanathan, M, Raymond, M, Rhee, C-S, Reitsma, S, Ryan, M, Sastre, J, Schlosser, R J, Schuman, T A, Shaker, M S, Sheikh, A, Daines, L, Smith, K A, Soyka, M B, Takashima, M, Tang, M, Tantilipikorn, P, Taw, M B, Tversky, J, Tyler, M A, Veling, M C, Wallace, D, Wang, D Y, White, A & Zhang, L 2023, ' International consensus statement on allergy and rhinology : Allergic rhinitis-2023 ', International Forum of Allergy & Rhinology (IFAR), vol. 13, no. 4, pp. 293-859 . https://doi.org/10.1002/alr.23090

BACKGROUND: In the 5 years that have passed since the publication of the 2018 International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR-Allergic Rhinitis 2018), the literature has expanded substantially. The ICAR-Allergic Rh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8bcc4f605531654fbf09111b189745
https://hdl.handle.net/20.500.11820/4de10f26-ba8b-48a4-a56a-68438ab280ae

Establishment and Characterization of a Sclerosing Spindle Cell Rhabdomyosarcoma Cell Line with a Complex Genomic Profile

Autor: Sabine Schleicher, Stefan Grote, Elke Malenke, Kenneth Chun-Ho Chan, Martin Schaller, Birgit Fehrenbacher, Rosa Riester, Torsten Kluba, Leonie Frauenfeld, Hans Boesmueller, Gudrun Göhring, Brigitte Schlegelberger, Rupert Handgretinger, Hans-Georg Kopp, Frank Traub, Karen A. Boehme

Publikováno v: Cells, Vol 9, Iss 12, p 2668 (2020)

Sclerosing spindle cell rhabdomyosarcoma (SSRMS) is a rare rhabdomyosarcomas (RMS) subtype. Especially cases bearing a myogenic differentiation 1 (MYOD1) mutation are characterized by a high recurrence and metastasis rate, often leading to a fatal ou

Externí odkaz: https://doaj.org/article/fd2b7cf0108b48bf81274a0d31f7d596