Proof of the concept to use a malignant B cell line drug screen strategy for identification and weight of melphalan resistance genes in multiple myeloma.

Autor: Martin Bøgsted, Anders E Bilgrau, Christopher P Wardell, Uta Bertsch, Alexander Schmitz, Julie S Bødker, Malene K Kjeldsen, Hartmut Goldschmidt, Gareth J Morgan, Karen Dybkaer, Hans E Johnsen

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83252 (2013)

In a conceptual study of drug resistance we have used a preclinical model of malignant B-cell lines by combining drug induced growth inhibition and gene expression profiling. In the current report a melphalan resistance profile of 19 genes were weigh

Externí odkaz: https://doaj.org/article/0778cf153500471da18c26b6bab43813

Diffuse large B-cell lymphoma classification system that associates normal B-cell subset phenotypes with prognosis.

Autor: Dybkær K; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Bøgsted M; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Falgreen S; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Bødker JS; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Kjeldsen MK; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Schmitz A; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Bilgrau AE; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Xu-Monette ZY; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Li L; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Bergkvist KS; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Laursen MB; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Rodrigo-Domingo M; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Marques SC; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Rasmussen SB; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Nyegaard M; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Gaihede M; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Møller MB; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Samworth RJ; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Shah RD; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Johansen P; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., El-Galaly TC; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Young KH; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom., Johnsen HE; Karen Dybkær, Martin Bøgsted, Steffen Falgreen, Julie S. Bødker, Malene K. Kjeldsen, Alexander Schmitz, Anders E. Bilgrau, Kim S. Bergkvist, Maria B. Laursen, Maria Rodrigo-Domingo, Sara C. Marques, Sophie B. Rasmussen, Mette Nyegaard, Michael Gaihede, Preben Johansen, Tarec C. El-Galaly, and Hans E. Johnsen, Aalborg University Hospital; Karen Dybkær, Martin Bøgsted, Anders E. Bilgrau, Maria Rodrigo-Domingo, Michael Gaihede, and Hans E. Johnsen, Aalborg University, Aalborg; Michael B. Møller, Odense University Hospital, Odense, Denmark; Zijun Y. Xu-Monette, Ling Li, and Ken H. Young, The University of Texas MD Anderson Cancer Center, Houston, TX; and Richard J. Samworth and Rajen D. Shah, University of Cambridge, Cambridge, United Kingdom. haej@rn.dk.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2015 Apr 20; Vol. 33 (12), pp. 1379-88. Date of Electronic Publication: 2015 Mar 23.