Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Malene E. Lindholm"'
Autor:
Carla Geiger, Maria Needhamsen, Eric B. Emanuelsson, Jessica Norrbom, Karen Steindorf, Carl Johan Sundberg, Stefan M. Reitzner, Malene E. Lindholm
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Physical activity is well known for its multiple health benefits and although the knowledge of the underlying molecular mechanisms is increasing, our understanding of the role of epigenetics in long-term training adaptation remain
Externí odkaz:
https://doaj.org/article/03cc6866958f4fd896733d137675689d
Autor:
David Amar, Malene E. Lindholm, Jessica Norrbom, Matthew T. Wheeler, Manuel A. Rivas, Euan A. Ashley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Regular exercise promotes overall health and prevents non-communicable diseases, but the adaptation mechanisms are unclear. Here, the authors perform a meta-analysis to reveal time-specific patterns of the acute and long-term exercise response in hum
Externí odkaz:
https://doaj.org/article/23884a9bb5dd4087b4ca76abb19bc960
Autor:
Sarah Voisin, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Vernon G. Coffey, Thomas M. Doering, Jamie‐Lee M. Thompson, Christian Benedict, Jonathan Cedernaes, Malene E. Lindholm, Jeffrey M. Craig, David S. Rowlands, Adam P. Sharples, Steve Horvath, Nir Eynon
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 4, Pp 887-898 (2020)
Abstract Background Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the original pan‐tissue
Externí odkaz:
https://doaj.org/article/ec55613c73c94b0fb371d3e39d3407b6
Autor:
Anna Wiik, Daniel P. Andersson, Torkel B. Brismar, Setareh Chanpen, Cecilia Dhejne, Tomas J. Ekström, John N. Flanagan, Mats Holmberg, Juha Kere, Mats Lilja, Malene E. Lindholm, Tommy R. Lundberg, Eva Maret, Michael Melin, Sofie M. Olsson, Eric Rullman, Kerstin Wåhlén, Stefan Arver, Thomas Gustafsson
Publikováno v:
Contemporary Clinical Trials Communications, Vol 10, Iss , Pp 148-153 (2018)
Background: Although the divergent male and female differentiation depends on key genes, many biological differences seen in men and women are driven by relative differences in estrogen and testosterone levels. Gender dysphoria denotes the distress t
Externí odkaz:
https://doaj.org/article/5ad1f734c819490e83d66f973c6db60f
Autor:
Christopher DeBoever, Yosuke Tanigawa, Malene E. Lindholm, Greg McInnes, Adam Lavertu, Erik Ingelsson, Chris Chang, Euan A. Ashley, Carlos D. Bustamante, Mark J. Daly, Manuel A. Rivas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Protein-truncating variants (PTVs) are predicted to significantly affect a gene’s function and, thus, human traits. Here, DeBoever et al. systematically analyze PTVs in more than 300,000 individuals across 135 phenotypes and identify 27 association
Externí odkaz:
https://doaj.org/article/4ce5ec51846e458aa6a36cea259e640a
Autor:
Sarah Voisin, Kirsten Seale, Macsue Jacques, Shanie Landen, Nicholas R Harvey, Larisa M Haupt, Lyn R Griffiths, Kevin J Ashton, Vernon G Coffey, Jamie-Lee M Thompson, Thomas M Doering, Malene E Lindholm, Colum Walsh, Gareth Davison, Rachelle Irwin, Catherine McBride, Ola Hansson, Olof Asplund, Aino E Heikkinen, Päivi Piirilä, Kirsi H Pietiläinen, Miina Ollikainen, Sara Blocquiaux, Martine Thomis, Dawn K Coletta, Adam P Sharples, Nir Eynon
Publikováno v:
Aging Cell.
Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate, or reverse
Autor:
Marcus Moberg, Stefan Markus Reitzner, C. J. Sundberg, Malene E. Lindholm, Niklas Psilander, Björn Ekblom
Publikováno v:
Medicine & Science in Sports & Exercise. 52:1679-1690
Introduction Human skeletal muscle is thought to have heightened sensitivity to exercise stimulus when it has been previously trained (i.e., it possesses "muscle memory"). We investigated whether basal and acute resistance exercise-induced gene expre
Autor:
Han Zhu, Kara S. Motonaga, Julia Platt, Gerald J. Berry, Chunli Zhao, Shirley Sutton, Kyla Dunn, Euan A. Ashley, Cedric Espenel, Archana Raja, Malene E. Lindholm, Matthew T. Wheeler, David Jimenez-Morales, Roshni Madhvani, David Amar, Sarah Abramowitz, Kinya Seo, Colleen Caleshu
Publikováno v:
Circ Genom Precis Med
Background: ACTN2 (alpha-actinin 2) anchors actin within cardiac sarcomeres. The mechanisms linking ACTN2 mutations to myocardial disease phenotypes are unknown. Here, we characterize patients with novel ACTN2 mutations to reveal insights into the ph
Autor:
Julia Platt, Roshni Madhvani, Archana Raja, Matthew T. Wheeler, Malene E. Lindholm, Chunli Zhao, Gerald J. Berry, Kara S. Motonaga, Han Zhu, Kinya Seo, Euan A. Ashley, Shirley Sutton, Cedric Espenel, David Jimenez-Morales, Kyla Dunn, Colleen Caleshu, David Amar
Alpha-actinin 2 (ACTN2) anchors actin within cardiac sarcomeres. The mechanisms linkingACTN2mutations to myocardial disease phenotypes are unknown. Here, we characterize patients with novelACTN2mutations to reveal insights into the physiological func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c3499bc8a7846c21f8e3aee59b07fe9
https://doi.org/10.1101/2020.11.19.389064
https://doi.org/10.1101/2020.11.19.389064
Autor:
Malene E. Lindholm, Kinya Seo, Matthew T. Wheeler, David Jimenez-Morales, Euan A. Ashley, Chunli Zhao, Han Zhu
Publikováno v:
Circulation. 142
Background and Aim: Cardiomyopathy is a common cause of sudden cardiac death in children that often requires heart transplantation. Alpha-actinins are critical cytoskeletal proteins that anchor actin filaments within the cardiac sarcomere. Mutations