Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Malene, Winther"'
Autor:
Skriver, Lea Kirstine Lewerenz, Nielsen, Malene Winther, Walther, Simone, Nørlev, Jannie Damsgaard, Hangaard, Stine
Publikováno v:
In Journal of Diabetes and Its Complications October 2023 37(10)
Autor:
Kim Krighaar Rasmussen, Maria Hansen Falkesgaard, Malene Winther, Nikolaj Kulahin Roed, Christine Louise Quistgaard, Marie Nygaard Teisen, Sofie Marie Edslev, David Leander Petersen, Ali Aljubouri, Claus Christensen, Peter Waaben Thulstrup, Leila Lo Leggio, Kaare Teilum, Peter Schledermann Walmod
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. In this study we investigate and compare the structures and functions of these FnIII domains. The NCAM1 and -2 FnIII2 domains both con
Externí odkaz:
https://doaj.org/article/0d20311e21774d27b2f15fe4f66a9f48
Publikováno v:
Data in Brief, Vol 8, Iss , Pp 411-414 (2016)
The data described here is related to the research article titled (Gabl et al., 2016) [1]. Pepducins with peptide sequence derived from one of the intracellular domains of a given G-protein coupled receptor (GPCR) can either activate or inhibit cell
Externí odkaz:
https://doaj.org/article/06d48cf33d7047f3a4b47128e2885a98
Autor:
Malene Winther, André Holdfeldt, Martina Sundqvist, Zahra Rajabkhani, Michael Gabl, Johan Bylund, Claes Dahlgren, Huamei Forsman
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185132 (2017)
A pepducin is a lipopeptide containing a peptide sequence that is identical to one of the intracellular domains of the G-protein coupled receptor (GPCR) assumed to be the target. Neutrophils express two closely related formyl peptide receptors belong
Externí odkaz:
https://doaj.org/article/7431dc9a849244768e2109446e70f56d
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167529 (2016)
Two different immune recognition systems have evolved in parallel to recognize peptides starting with an N-formylated methionine, and recognition similarities/differences between these two systems have been investigated. A number of peptides earlier
Externí odkaz:
https://doaj.org/article/99cb0ea487684802a70d223cc704bb9c
Autor:
Michael Gabl, Malene Winther, Sarah Line Skovbakke, Johan Bylund, Claes Dahlgren, Huamei Forsman
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109516 (2014)
We recently described a novel receptor cross-talk mechanism in neutrophils, unique in that the signals generated by the PAF receptor (PAFR) and the ATP receptor (P2Y2R) transfer formyl peptide receptor 1 (FPR1) from a desensitized (non-signaling) sta
Externí odkaz:
https://doaj.org/article/05d1c136d91f49c99cd12a46a74ba7bf
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 122:191-198
The pattern recognition formyl peptide receptors (FPRs) belong to the class of G-protein-coupled receptors (GPCRs), the largest group of cell surface receptors involved in a range of physiological processes and pathologies. The FPRs have regulatory f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d712efd5e071c35a3b732d1b7d0ff75
https://doi.org/10.1111/bcpt.12903
https://doi.org/10.1111/bcpt.12903
Autor:
Sara K. Lindén, Claes Dahlgren, Huamei Forsman, Ji Ming Wang, Malene Winther, Henrik Franzyk, Michael Gabl, Sarah Line Skovbakke, André Holdfeldt
Publikováno v:
Biochemical Pharmacology. 119:56-65
The formyl peptide receptor (FPR) gene family has a complex evolutionary history and comprises eight murine members but only three human representatives. To enable translation of results obtained in mouse models of human diseases, more comprehensive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81933e86dbe0fc13e37b705c22df0229
https://doi.org/10.1016/j.bcp.2016.09.004
https://doi.org/10.1016/j.bcp.2016.09.004
Autor:
Christina Nielsen, Iris Perez-Gassol, Anna Karlsson, Michael Gabl, Camilla Josephine Larsen, Huamei Forsman, Claes Dahlgren, Malene Winther, Ji Ming Wang, Sarah Line Skovbakke, André Holdfeldt, Henrik Franzyk
Publikováno v:
Holdfeldt, A, Skovbakke, S L, Winther, M, Gabl, M, Nielsen, C, Perez-Gassol, I, Larsen, C J, Wang, J M, Karlsson, A, Dahlgren, C, Forsman, H & Franzyk, H 2016, ' The Lipidated Peptidomimetic Lau-((S)-Aoc)-(Lys-βNphe)6-NH2Is a Novel Formyl Peptide Receptor 2 Agonist That Activates Both Human and Mouse Neutrophil NADPH Oxidase ', Journal of Biological Chemistry . https://doi.org/10.1074/jbc.m116.736850
Neutrophils expressing formyl peptide receptor 2 (FPR2) play key roles in host defense, immune regulation, and resolution of inflammation. Consequently, the search for FPR2-specific modulators has attracted much attention due to its therapeutic poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dc119f85aaa45ef121e1c2a6ec4143
https://doi.org/10.1074/jbc.m116.736850
https://doi.org/10.1074/jbc.m116.736850
Publikováno v:
FEBS Letters. 589:1832-1839
Pepducins constitute a unique class of G-protein coupled receptor (GPCR) modulating lipopeptides. Pepducins with inhibitory effects on neutrophils could potentially be developed into anti-inflammatory pharmaceuticals. A pepducin with a peptide sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fae68dac9ee9aa90fac11b2719b8c84
https://doi.org/10.1016/j.febslet.2015.05.050
https://doi.org/10.1016/j.febslet.2015.05.050