Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Autor: Qing Li, Jieyi Chen, Pierre Faux, Miguel Eduardo Delgado, Betty Bonfante, Macarena Fuentes-Guajardo, Javier Mendoza-Revilla, J. Camilo Chacón-Duque, Malena Hurtado, Valeria Villegas, Vanessa Granja, Claudia Jaramillo, William Arias, Rodrigo Barquera, Paola Everardo-Martínez, Mirsha Sánchez-Quinto, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Caio C. Silva de Cerqueira, Tábita Hünemeier, Virginia Ramallo, Sijie Wu, Siyuan Du, Andrea Giardina, Soumya Subhra Paria, Mahfuzur Rahman Khokan, Rolando Gonzalez-José, Lavinia Schüler-Faccini, Maria-Cátira Bortolini, Victor Acuña-Alonzo, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Winston Rojas, Francisco Rothhammer, Nicolas Navarro, Sijia Wang, Kaustubh Adhikari, Andrés Ruiz-Linares

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)

Abstract We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value

Externí odkaz: https://doaj.org/article/5c1a3dadff9443b1a106b728742be5d4

Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Autor: Juan-Camilo Chacón-Duque, Kaustubh Adhikari, Macarena Fuentes-Guajardo, Javier Mendoza-Revilla, Victor Acuña-Alonzo, Rodrigo Barquera, Mirsha Quinto-Sánchez, Jorge Gómez-Valdés, Paola Everardo Martínez, Hugo Villamil-Ramírez, Tábita Hünemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Mercedes Villena, René Vásquez, Elena Llop, José R. Sandoval, Alberto A. Salazar-Granara, Maria-Laura Parolin, Karla Sandoval, Rosenda I. Peñaloza-Espinosa, Hector Rangel-Villalobos, Cheryl A. Winkler, William Klitz, Claudio Bravi, Julio Molina, Daniel Corach, Ramiro Barrantes, Verónica Gomes, Carlos Resende, Leonor Gusmão, Antonio Amorim, Yali Xue, Jean-Michel Dugoujon, Pedro Moral, Rolando González-José, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Giovanni Poletti, Carla Gallo, Gabriel Bedoya, Francisco Rothhammer, David Balding, Garrett Hellenthal, Andrés Ruiz-Linares

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)

Latin Americans trace their ancestry to the admixture of Native Americans, Europeans and Sub-Saharan Africans. Here, the authors develop a novel haplotype-based approach and analyse over 6,500 Latin Americans to infer the geographically-detailed gene

Externí odkaz: https://doaj.org/article/1bf119c84db44cd5b09c50f6b00d3141

A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

Autor: Kaustubh Adhikari, Tania Fontanil, Santiago Cal, Javier Mendoza-Revilla, Macarena Fuentes-Guajardo, Juan-Camilo Chacón-Duque, Farah Al-Saadi, Jeanette A. Johansson, Mirsha Quinto-Sanchez, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Gastón Macín Pérez, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Tábita Hunemeier, Virginia Ramallo, Caio C. Silva de Cerqueira, Malena Hurtado, Valeria Villegas, Vanessa Granja, Carla Gallo, Giovanni Poletti, Lavinia Schuler-Faccini, Francisco M. Salzano, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Francisco Rothhammer, Gabriel Bedoya, Rolando Gonzalez-José, Denis Headon, Carlos López-Otín, Desmond J. Tobin, David Balding, Andrés Ruiz-Linares

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

By examining Latin American individuals of mixed European, Native American and African ancestry, Adhikari et al. identify novel loci influencing various features of facial and scalp hair. The study also provides experimental evidence that one of the

Externí odkaz: https://doaj.org/article/0f97fbb66079458f805844b2d61b335e

Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes

Autor: Maria A. Nieves-Colón, Keyla M. Badillo Rivera, Karla Sandoval, Vanessa Villanueva Dávalos, Luis E. Enriquez Lencinas, Javier Mendoza-Revilla, Kaustubh Adhikari, Ram González-Buenfil, Jessica W. Chen, Elisa T. Zhang, Alexandra Sockell, Patricia Ortiz-Tello, Gloria Malena Hurtado, Ramiro Condori Salas, Ricardo Cebrecos, José C. Manzaneda Choque, Franz P. Manzaneda Choque, Germán P. Yábar Pilco, Erin Rawls, Celeste Eng, Scott Huntsman, Esteban Burchard, Andrés Ruiz-Linares, Rolando González-José, Gabriel Bedoya, Francisco Rothhammer, Maria Cátira Bortolini, Giovanni Poletti, Carla Gallo, Carlos D. Bustamante, Julie C. Baker, Christopher R. Gignoux, Genevieve L. Wojcik, Andrés Moreno-Estrada

Publikováno v: Am J Hum Genet

Preeclampsia is a multi-organ complication of pregnancy characterized by sudden hypertension and proteinuria that is among the leading causes of preterm delivery and maternal morbidity and mortality worldwide. The heterogeneity of preeclampsia poses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613401ec1e841476bab8a6d428f015a3
http://oro.open.ac.uk/83518/1/manuscript_oro_ajhg.pdf

Disentangling signatures of selection before and after European colonization in Latin Americans

Autor: Javier Mendoza-Revilla, Juan Camilo Chacón-Duque, Macarena Fuentes-Guajardo, Louise Ormond, Ke Wang, Malena Hurtado, Valeria Villegas, Vanessa Granja, Victor Acuña-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera Lozano, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Caio C. Silva de Cerqueira, Keyla M. Badillo Rivera, Maria A. Nieves-Colón, Christopher R. Gignoux, Genevieve L. Wojcik, Andrés Moreno-Estrada, Tábita Hunemeier, Virginia Ramallo, Lavinia Schuler-Faccini, Rolando Gonzalez-José, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, David Balding, Matteo Fumagalli, Kaustubh Adhikari, Andrés Ruiz-Linares, Garrett Hellenthal

Publikováno v: Molecular Biology and Evolution
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated human groups. Although classical and recent work have shown that studying admixture can yield novel historical insigh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609fb1aab8eb1b785ab3d7e7231f8fbc
https://doi.org/10.1101/2021.11.15.467418