Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Malek Faham"'
Autor:
Xinxing Li, Tao Liu, Antonella Bacchiocchi, Mengxing Li, Wen Cheng, Tobias Wittkop, Fernando L Mendez, Yingyu Wang, Paul Tang, Qianqian Yao, Marcus W Bosenberg, Mario Sznol, Qin Yan, Malek Faham, Li Weng, Ruth Halaban, Hai Jin, Zhiqian Hu
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2188-2209 (2024)
Abstract While whole genome sequencing (WGS) of cell-free DNA (cfDNA) holds enormous promise for detection of molecular residual disease (MRD), its performance is limited by WGS error rate. Here we introduce AccuScan, an efficient cfDNA WGS technolog
Externí odkaz:
https://doaj.org/article/61e8893361234a0aaada760b5863e691
Autor:
Prisca M.J. Theunissen, David van Zessen, Andrew P. Stubbs, Malek Faham, Christian M. Zwaan, Jacques J.M. van Dongen, Vincent H.J. Van Der Velden
Publikováno v:
Haematologica, Vol 102, Iss 11 (2017)
In B-cell precursor acute lymphoblastic leukemia, the initial leukemic cells share the same antigen receptor gene rearrangements. However, due to ongoing rearrangement processes, leukemic cells with different gene rearrangement patterns can develop,
Externí odkaz:
https://doaj.org/article/e34f4e8107b84824a566853750a2331f
Autor:
Mark Klinger, Francois Pepin, Jen Wilkins, Thomas Asbury, Tobias Wittkop, Jianbiao Zheng, Martin Moorhead, Malek Faham
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141561 (2015)
Monitoring antigen-specific T cells is critical for the study of immune responses and development of biomarkers and immunotherapeutics. We developed a novel multiplex assay that combines conventional immune monitoring techniques and immune receptor r
Externí odkaz:
https://doaj.org/article/5e07b9e6e82e43fdb44cf1bbe5b395fa
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74231 (2013)
In this study, we combined a novel sequencing method, which can identify individual clonotypes based on their unique T cell receptor (TCR) rearrangement, with existing immune assays to characterize antigen-specific T cell responses. We validated this
Externí odkaz:
https://doaj.org/article/3c0b400766774c81a49228d135ae0fd6
Autor:
Lawrence Fong, Malek Faham, Mark Klinger, Serena S. Kwek, Grant Fong, Li Zhang, Jason Cham, David Y. Oh
The supplementary file contains 3 supplemental figures. Supplementary Figure S1 shows the kinetics of Ki67 expression by CD4 and CD8 T cells following treatment with ipilimumab. Supplementary Figure S2 shows the change in TCR clonality over time foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8e9db46c708b4ccbf725dda84f8be0
https://doi.org/10.1158/0008-5472.22415876.v1
https://doi.org/10.1158/0008-5472.22415876.v1
Autor:
Lawrence Fong, Malek Faham, Mark Klinger, Serena S. Kwek, Grant Fong, Li Zhang, Jason Cham, David Y. Oh
While immune checkpoint blockade elicits efficacious responses in many patients with cancer, it also produces a diverse and unpredictable number of immune-related adverse events (IRAE). Mechanisms driving IRAEs are generally unknown. Because CTLA-4 b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf782bd2033767511b171f0d807bcff1
https://doi.org/10.1158/0008-5472.c.6509408.v1
https://doi.org/10.1158/0008-5472.c.6509408.v1
Autor:
Ronald W. Davis, James M. Ford, Malek Faham, Keyan Salari, Kyle Farnam, Michael Zhang, Jochen Kumm, Hanlee Ji
Genomic instability is a major feature of neoplastic development in colorectal carcinoma and other cancers. Specific genomic instability events, such as deletions in chromosomes and other alterations in gene copy number, have potential utility as bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cac99092875e9a630ff30e66a5b73af
https://doi.org/10.1158/0008-5472.c.6494673.v1
https://doi.org/10.1158/0008-5472.c.6494673.v1
Autor:
Ronald W. Davis, James M. Ford, Malek Faham, Keyan Salari, Kyle Farnam, Michael Zhang, Jochen Kumm, Hanlee Ji
Supplementary Data 1 from Molecular Inversion Probe Analysis of Gene Copy Alterations Reveals Distinct Categories of Colorectal Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4d687c40cdd84a0a5eba6c6df2c7eb
https://doi.org/10.1158/0008-5472.22365375
https://doi.org/10.1158/0008-5472.22365375
Autor:
Philippe Moreau, Laurent Garderet, Bertrand Arnulf, Sabrina Maheo, Lotfi Benboubker, Mamoun Dib, Sabine Brechignac, Nelly Robillard, Mohamad Mohty, Margaret Macro, Brigitte Pegourie, Thierry Facon, Brigitte Kolb, Karim Belhadj, Nikhil C. Munshi, Bruno Royer, Olivier Decaux, Arnaud Jaccard, Valérie Lauwers-Cances, Marie-Lorraine Chretien, Anne-Marie Stoppa, Hervé Avet-Loiseau, Xavier Leleu, Kenneth C. Anderson, Jean-Richard Eveillard, Martin Moorhead, Chantal Doyen, Cecile Fohrer, Lionel Karlin, Jill Corre, Victoria Carlton, Paul G. Richardson, Malek Faham, Jean-Luc Harousseau, Michel Attal, Nathalie Meuleman, Thomas D. Willis, Aurore Perrot, Cyrille Hulin, Thomas Dejoie
Publikováno v:
Blood
Blood, American Society of Hematology, 2018, 132 (23), pp.2456-2464. ⟨10.1182/blood-2018-06-858613⟩
Blood, Vol. 132, no. 23, p. 2456-2464 (2018)
Blood, American Society of Hematology, 2018, 132 (23), pp.2456-2464. ⟨10.1182/blood-2018-06-858613⟩
Blood, Vol. 132, no. 23, p. 2456-2464 (2018)
IF 15.132 (2017); International audience; The introduction of novel agents has led to major improvements in clinical outcomes for patients with multiple myeloma. To shorten evaluation times for new treatments, health agencies are currently examining
Autor:
Ash A. Alizadeh, Kevin Sheehan, Neel K. Gupta, Debra K. Czerwinski, Malek Faham, Ole Audun Werner Haabeth, Andrew R. Rezvani, Ginna G. Laport, Michael P. Chu, Matthew J. Frank, Irene Wapnir, Sunil Reddy, Michael S. Khodadoust, Everett Meyer, Robert S. Negrin, Ami Okada, David B. Miklos, Ranjana H. Advani, Joshua Brody, Destiny L Phillips, Lauren S. Maeda, Ronald Levy, A Holliston Moore, Wen-Kai Weng
Publikováno v:
The Journal of Experimental Medicine
A CpG-stimulated autologous tumor cell vaccine for patients with MCL is safe and feasible and induces detectable antitumor T cell immune responses. Patients who received the CpG-MCL vaccination demonstrated freedom from MRD at 1 yr after ASCT that su