Zobrazeno 1 - 10
of 8 148
pro vyhledávání: '"Maleimide"'
Autor:
Karol Biernacki, Olga Ciupak, Mateusz Daśko, Janusz Rachon, Damian Flis, Justyna Budka, Iwona Inkielewicz-Stępniak, Anna Czaja, Janusz Rak, Sebastian Demkowicz
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus
Externí odkaz:
https://doaj.org/article/cdb6c235654144bfbb03ab8413a8952f
Akademický článek
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Autor:
Ingram, N., Abou-Saleh, R.H., Race, Amanda D., Loadman, Paul, Bushby, R.J., Evans, S.D., Coletta, P.L.
Yes
Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of t
Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of t
Externí odkaz:
http://hdl.handle.net/10454/19981
Akademický článek
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Autor:
Hye Jin Kim, Lee Kyung Kim, Anna Kim, Khin Myo Htwe, Tae-Hwe Heo, Kye Jung Shin, Hee Jung Kim, Kee Dong Yoon
Publikováno v:
Molecules, Vol 29, Iss 13, p 2981 (2024)
Piper attenuatum Buch-Ham, a perennial woody vine belonging to the Piperaceae family, is traditionally used in Southeast Asia for treating various ailments such as malaria, headache, and hepatitis. This study described the isolation and identificatio
Externí odkaz:
https://doaj.org/article/28085e8147444a768e8e4e375ab35e22
Publikováno v:
Open Chemistry, Vol 21, Iss 1, Pp 293-9 (2023)
Dual functionalization of targeting vectors, such as peptides and antibodies, is still synthetically challenging despite the increasing demand for such molecules serving multiple purposes (i.e., optical and nuclear imaging). Our strategy was to synth
Externí odkaz:
https://doaj.org/article/af2953b11aae4b398a96fc971dcac429
Publikováno v:
AppliedChem, Vol 3, Iss 2, Pp 256-278 (2023)
Novel SF5-bearing maleimide and acrylamide derivatives were synthesised as potential [18F]radio-prosthetic groups for radiolabelling peptides and proteins. The efficacy of selected prosthetic groups was first assessed through bioconjugation with prot
Externí odkaz:
https://doaj.org/article/38bb9aeb8a224f96bd63bdb076b44e48
Autor:
Ying Xu, Huiting Li, Xiongyan Meng, Jing Yang, Yannan Xue, Changcai Teng, Wenxin Lv, Zhen Wang, Xiaodan Li, Tiantian Sun, Shuai Meng, Chengli Zong
Publikováno v:
Polymers, Vol 16, Iss 7, p 931 (2024)
Vaccines typically work by eliciting an immune response against larger antigens like polysaccharides or proteins. Small molecules like nicotine, on their own, usually cannot elicit a strong immune response. To overcome this, anti-nicotine vaccines of
Externí odkaz:
https://doaj.org/article/de575aaf1d19497995a0cae90e81762a
Autor:
Nicola Ingram, Radwa H. Abou-Saleh, Amanda D. Race, Paul M. Loadman, Richard J. Bushby, Stephen D. Evans, P. Louise Coletta
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 434 (2024)
Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of thMBs curr
Externí odkaz:
https://doaj.org/article/abff952cecfb4e338f01079ea86da640
Akademický článek
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