Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes.

Autor: Fan C; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Cohen AA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Park M; Department of Molecular Medicine, City of Hope, Duarte, CA 91010, USA., Hung AF; Department of Molecular Medicine, City of Hope, Duarte, CA 91010, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gnanapragasam PNP; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Lee YE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Gao H; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kakutani LM; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Wu Z; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Kleanthous H; Bill and Melinda Gates Foundation, Seattle, WA 98109, USA., Malecek KE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA., Williams JC; Department of Molecular Medicine, City of Hope, Duarte, CA 91010, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: bjorkman@caltech.edu.

Publikováno v: Immunity [Immunity] 2022 Dec 13; Vol. 55 (12), pp. 2419-2435.e10. Date of Electronic Publication: 2022 Oct 27.