Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Malcolm York"'
Autor:
Malcolm York, Anastasia Dasopoulou, José J. Cerón, Sonal Patel, Christos K. Koutinas, Mitul Gandhi, Ian Roman, Zoe S. Polizopoulou, Asta Tvarijonaviciute, Peter J. O'Brien, Silvia Martínez-Subiela
Publikováno v:
Veterinary Clinical Pathology. 44:397-404
Background Cardiac troponin I (cTnI) correlates with severity of myocardial injury. Nonspecific inflammation in congestive heart failure (CHF) could be assessed by C-reactive protein (CRP), haptoglobin (Hp), and ceruloplasmin (Cp) measurements. Objec
Autor:
Mitul Gandhi, Ian Roman, Alexander F. Koutinas, Malcolm York, Christos K. Koutinas, Michael Patsikas, Zoe S. Polizopoulou, Anastasia Dasopoulou, Peter J. O'Brien, Sonal Patel
Publikováno v:
Veterinary Clinical Pathology. 43:218-225
Background Cardiac troponin I (cTnI) is a biomarker correlated with the severity of myocardial injury. It is hypothesized that serial assessment of cTnI could provide information about the disease progression in chronic heart failure. Objective The p
Publikováno v:
Toxicologic Pathology. 41:1146-1158
Cardiac troponin (cTn) has been utilized to assess acute myocardial injury, but the cTn response in active/ongoing chronic injury is not well documented. The purpose of this study was to characterize the cardiac troponin I (cTnI), cardiac troponin T
Autor:
Brian R. Berridge, Malcolm York, A. Casartelli, Kimberly Roland, Rick R. Adler, Alan H. Stokes, Rhiannon C. Davies, Patrizia Cristofori, Federica Crivellente, Carie L. Kimbrough, Franck Chanut, Rick Hailey, Holly L. Jordan, Jan Klapwijk, Angela Hughes-Earle, Heath C. Thomas
Publikováno v:
Toxicologic Pathology. 41:1126-1136
Cardiovascular safety signals in nonclinical studies remain among the main reasons for drug attrition during pharmaceutical research and development. Drug-induced changes can be functional and/or associated with morphological alterations in the norma
Autor:
Robert R. Maronpot, Agnes Schulte, Karin Küttler, A. Nishikawa, Takanori Harada, Anthony P. Hall, Thomas Nolte, David E. Malarkey, John R. Foster, C. R. Elcombe, Wolfgang Kaufmann, Volker Strauss, Malcolm York, Anja Knippel
Publikováno v:
Toxicologic Pathology. 40:971-994
Preclinical toxicity studies have demonstrated that exposure of laboratory animals to liver enzyme inducers during preclinical safety assessment results in a signature of toxicological changes characterized by an increase in liver weight, hepatocellu
Autor:
Michael R. Munday, Rosemary Smyth, Malcolm York, John Turton, Jennifer Woodfine, David P. Maguire, Mitul Gandhi, Ines Pereira, John Bowles, Cheryl L. Scudamore, Surjit Sondh, Ian Francis, Aubrey Swain, Sofia Freitas, Clare Stamp, Holly Ashall
Publikováno v:
Journal of Applied Toxicology. 32:417-428
Hexachloro-1:3-butadiene (HCBD) causes damage specifically to the renal proximal tubule in rats. In the present study, injury to the nephron of male Hanover Wistar rats was characterized at 24 h following dosing with HCBD in the range 5–90 mg kg−
Autor:
Michael R. Munday, Surjit Sondh, Ines Pereira, Cheryl L. Scudamore, Neeti Viswanathan, Aubrey Swain, John Turton, Rosemary Smyth, Malcolm York, Mitul Gandhi, Fiona McClure
Publikováno v:
Journal of Applied Toxicology. 31:366-377
Hexachloro-1:3-butadiene (HCBD) causes kidney injury specific to the pars recta of the proximal tubule. In the present studies, injury to the nephron was characterized at 24 h following a single dose of HCBD, using a range of quantitative urinary mea
Autor:
Calvert Louden, Frank Dieterle, William J. Reagan, Malcolm York, Dominique Brees, David Reynolds
Publikováno v:
Toxicologic Pathology. 38:203-206
Systemic inflammatory response syndrome (SIRS) is a ‘‘state of whole body inflammation’’ that can result in multiple organ dysfunction (MOD) circulatory collapse and even death. SIRS is considered as a self-defense mechanism to nonspecific in
Autor:
Malcolm York, Brian R. Berridge, Eugene H. Herman, Dana Walker, Fred S. Apple, Albert E. Schultze, Steven E. Lipshultz, A.S. Jaffe, William J. Reagan, Syril Pettit
Publikováno v:
American Heart Journal. 158:21-29
Cardiac troponins (cTns) are established biomarkers of ischemic heart disease in humans. However, their value as biomarkers of cardiac injury from causes other than ischemic heart disease is now being explored, particularly in drug development. In a
Autor:
Malcolm York, Thomas C. Williams, Sally Brady, Ian Roman, Dai Davies, Brian R. Berridge, Dana Walker, John Turton, Rosemary Nicklaus, Igor Mikaelian, Peter Clements, Clare Stamp, Syril Pettit, Mitu Gandhi
Publikováno v:
Toxicologic Pathology. 36:149-176