Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Malcolm Weir"'
Autor:
Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart, Erica S. Klaassen, Robert Jan Doll, Giles A. Brown, Alastair Brown, Miles Congreve, Malcolm Weir, Fiona H. Marshall, David M. Cross, Geert Jan Groeneveld, Pradeep J. Nathan
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2021)
Abstract Background The cholinergic system and M1 receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M1 receptor partial agonist HTL0018318 is under development for the symptomatic treatment of Demen
Externí odkaz:
https://doaj.org/article/8f25b2ca13ee46c9988b118de2ad5f58
Autor:
Charlotte, Bakker, Tim, Tasker, Jan, Liptrot, Ellen P, Hart, Erica S, Klaassen, Samantha, Prins, Thalia F, van der Doef, Giles A, Brown, Alastair, Brown, Miles, Congreve, Malcolm, Weir, Fiona H, Marshall, David M, Cross, Geert Jan, Groeneveld, Pradeep J, Nathan
Publikováno v:
British Journal of Clinical Pharmacology
Aims HTL0018318 is a selective M1 receptor partial agonist currently under development for the symptomatic treatment of cognitive and behavioural symptoms in Alzheimer's disease and other dementias. We investigated safety, tolerability, pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7df3ed4c11e17aec9b466713a2297cab
https://pubmed.ncbi.nlm.nih.gov/33351971
https://pubmed.ncbi.nlm.nih.gov/33351971
Autor:
Charlotte, Bakker, Tim, Tasker, Jan, Liptrot, Ellen P, Hart, Erica S, Klaassen, Robert Jan, Doll, Giles A, Brown, Alastair, Brown, Miles, Congreve, Malcolm, Weir, Fiona H, Marshall, David M, Cross, Geert Jan, Groeneveld, Pradeep J, Nathan
Publikováno v:
Alzheimer's Research & Therapy
Background The cholinergic system and M1 receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M1 receptor partial agonist HTL0018318 is under development for the symptomatic treatment of Dementia’s i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f321965e92eabde84ef76a2dcf9e89b0
https://pubmed.ncbi.nlm.nih.gov/33883008
https://pubmed.ncbi.nlm.nih.gov/33883008
Autor:
Alastair J H, Brown, Sophie J, Bradley, Fiona H, Marshall, Giles A, Brown, Kirstie A, Bennett, Jason, Brown, Julie E, Cansfield, David M, Cross, Chris, de Graaf, Brian D, Hudson, Louis, Dwomoh, João M, Dias, James C, Errey, Edward, Hurrell, Jan, Liptrot, Giulio, Mattedi, Colin, Molloy, Pradeep J, Nathan, Krzysztof, Okrasa, Greg, Osborne, Jayesh C, Patel, Mark, Pickworth, Nathan, Robertson, Shahram, Shahabi, Christoffer, Bundgaard, Keith, Phillips, Lisa M, Broad, Anushka V, Goonawardena, Stephen R, Morairty, Michael, Browning, Francesca, Perini, Gerard R, Dawson, John F W, Deakin, Robert T, Smith, Patrick M, Sexton, Julie, Warneck, Mary, Vinson, Tim, Tasker, Benjamin G, Tehan, Barry, Teobald, Arthur, Christopoulos, Christopher J, Langmead, Ali, Jazayeri, Robert M, Cooke, Prakash, Rucktooa, Miles S, Congreve, Malcolm, Weir, Andrew B, Tobin
Publikováno v:
Trends Pharmacol Sci
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7763e10dd2dc92975133618856c2920a
https://pubmed.ncbi.nlm.nih.gov/35101279
https://pubmed.ncbi.nlm.nih.gov/35101279
Autor:
Alastair J. H. Brown, Sophie J. Bradley, Giles A. Brown, Kirstie A. Bennett, Jason Brown, Julie E. Cansfield, David M. Cross, João M. Dias, James C. Errey, Edward Hurrell, Jan Liptrot, Colin Molloy, Pradeep J. Nathan, Krzysztof Okrasa, Greg Osbourne, Jayesh C. Patel, Mark Pickworth, Nathan Robertson, Shahram Shahabi, Christoffer Bundgaard, Keith Phillips, Lisa M. Broad, Anushka V. Goonawardena, Stephen R. Morairty, Michael Browning, Francesca Perini, Gerard R. Dawson, John F. W. Deakin, Robert T. Smith, Patrick M. Sexton, Julie Warneck, Mary Vinson, Tim Tasker, Benjamin G. Tehan, Barry Teobald, Arthur Christopoulos, Christopher J. Langmead, Ali Jazayeri, Robert M. Cooke, Fiona H. Marshall, Prakash Rucktooa, Miles S. Congreve, Malcolm Weir, Andrew Tobin
Publikováno v:
SSRN Electronic Journal.
Current therapies for improving memory in Alzheimer’s disease are focused on correcting for defective cholinergic transmission by increasing acetylcholine levels through inhibition of acetylcholinesterase enzymes. These treatments are however assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9223ad5ca22fdc8ece3f25838d310314
https://doi.org/10.2139/ssrn.3641933
https://doi.org/10.2139/ssrn.3641933
Autor:
Mathieu Rappas, Ammar A. E. Ali, Kirstie A. Bennett, Jason D. Brown, Sarah J. Bucknell, Miles Congreve, Robert M. Cooke, Gabriella Cseke, Chris de Graaf, Andrew S. Doré, James C. Errey, Ali Jazayeri, Fiona H. Marshall, Jonathan S. Mason, Richard Mould, Jayesh C. Patel, Benjamin G. Tehan, Malcolm Weir, John A. Christopher
[Image: see text] The orexin system, which consists of the two G protein-coupled receptors OX(1) and OX(2), activated by the neuropeptides OX-A and OX-B, is firmly established as a key regulator of behavioral arousal, sleep, and wakefulness and has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0d1e9cf558d3f2bc1e5e706f4b6a9b
https://europepmc.org/articles/PMC7050010/
https://europepmc.org/articles/PMC7050010/
Autor:
Malcolm Weir
Publikováno v:
The Biochemist. 40:46-47
The Biochemical Society is committed to bringing together molecular bioscientists and supporting our members across the community. To this end there has been a renewed focus on those working in the industrial, biotechnology and academic drug discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656f15007dd559abbe8b9f41c9b5300d
https://doi.org/10.1042/bio04004046
https://doi.org/10.1042/bio04004046
Autor:
Peter Rijnen, Ramy Mahrous, Raul Navarro, Gert Lammers, Ronald Vader, Alastair Honey, Bjarne Salmelid, Enrique Larreal, Malcolm Weir
Publikováno v:
All Days.
For decades, wells targeting the Rotliegend reservoir in the Southern North Sea Basin have been drilled using conventional water-based mud (WBM) in the top hole section and oil-based mud (OBM) systems throughout the remaining sections of the well. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ce27aef3f5176b8ad5cc3e3bd70cfb
https://doi.org/10.2118/182286-ms
https://doi.org/10.2118/182286-ms
Autor:
Kirstie A, Bennett, Benjamin, Tehan, Guillaume, Lebon, Christopher G, Tate, Malcolm, Weir, Fiona H, Marshall, Christopher J, Langmead
Publikováno v:
Molecular pharmacology. 83(5)
Using isolated receptor conformations crystal structures of the adenosine A2A receptor have been solved in active and inactive states. Studying the change in affinity of ligands at these conformations allowed qualitative prediction of compound effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb868e2401da21b45cd0258fb2c92b10
https://pubmed.ncbi.nlm.nih.gov/23429888
https://pubmed.ncbi.nlm.nih.gov/23429888
Publikováno v:
Trends in biotechnology. 19
Functional genomic and proteomic technologies are producing biological data relating to hundreds, or even thousands of proteins per experiment. Rapid and accurate computational analysis of the molecular function of these proteins is therefore crucial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05494c3a68f44b248b5baefeede6da00
https://pubmed.ncbi.nlm.nih.gov/11780973
https://pubmed.ncbi.nlm.nih.gov/11780973