Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Malcolm V. Lane"'
Autor:
Ta-Chung M. Mou, Malcolm V. Lane, Derek D.C. Ireland, Daniela Verthelyi, Leonardo H. Tonelli, Sarah M. Clark
Publikováno v:
Neurobiology of Disease, Vol 173, Iss , Pp 105840- (2022)
An early inflammatory insult is the most recognized risk factor associated with neurodevelopmental psychiatric disorders, even more so than genetic variants. Notably, complement component 4 (C4), a molecule involved in inflammatory responses, has bee
Externí odkaz:
https://doaj.org/article/d110f1ad1f01476dbed0fb4f4eb11dda
Publikováno v:
bioRxiv
There is an increased incidence of autism among the children of women who take the anti-epileptic, mood stabilizing drug, valproic acid (VPA) during pregnancy; moreover, exposure to VPAin uterocauses autistic-like symptoms in rodents and non-human pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242bc46d540f75a72a2054a38f43e616
https://europepmc.org/articles/PMC10187231/
https://europepmc.org/articles/PMC10187231/
Autor:
Ta-Chung M. Mou, Malcolm V. Lane, Derek D.C. Ireland, Daniela Verthelyi, Leonardo H. Tonelli, Sarah M. Clark
Publikováno v:
Neurobiology of disease. 173
An early inflammatory insult is the most recognized risk factor associated with neurodevelopmental psychiatric disorders, even more so than genetic variants. Notably, complement component 4 (C4), a molecule involved in inflammatory responses, has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e753234f5cf01e776e59c0e3b879b44
https://pubmed.ncbi.nlm.nih.gov/35995342
https://pubmed.ncbi.nlm.nih.gov/35995342
Brain-Selective Estrogen Therapy Prevents Androgen Deprivation-Associated Hot Flushes in a Rat Model
Autor:
Christina A. Stennett, Laszlo Prokai, Istvan Merchenthaler, Katalin Prokai-Tatrai, Min Zhan, Vien Nguyen, Malcolm V. Lane
Publikováno v:
Pharmaceuticals
Volume 13
Issue 6
Pharmaceuticals, Vol 13, Iss 119, p 119 (2020)
Volume 13
Issue 6
Pharmaceuticals, Vol 13, Iss 119, p 119 (2020)
Hot flushes are best-known for affecting menopausal women, but men who undergo life-saving castration due to androgen-sensitive prostate cancer also suffer from these vasomotor symptoms. Estrogen deficiency in these patients is a direct consequence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bfdeedef28d9ead2b16f482f19512d
SUN-234 Brain-Selective Estrogen Therapy to Prevent Androgen Deprivation Therapy-Related Hot Flushes
Publikováno v:
Journal of the Endocrine Society
Synthetic estrogens are used in the clinic to alleviate debilitating neurological symptoms associated with androgen deprivation therapy (ADT), an effective treatment improving survival in prostate cancer patients when administered timely in the cours
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fb424d6e1cc6c5087ba94c5433982a
http://europepmc.org/articles/PMC7207823
http://europepmc.org/articles/PMC7207823
Autor:
Edna F. R. Pereira, William P. Fawcett, D'Arice Carter, Joseph D. Pescrille, Yasco Aracava, Malcolm V. Lane, G. William Basinger, Edson X. Albuquerque
Publikováno v:
J Pharmacol Exp Ther
Earlier reports suggested that galantamine, a drug approved to treat mild-to-moderate Alzheimer’s disease (AD), and other centrally acting reversible acetylcholinesterase (AChE) inhibitors can serve as adjunct pretreatments against poisoning by org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7001fb3eb6fde3924fcb47f099689e15
https://pubmed.ncbi.nlm.nih.gov/32759369
https://pubmed.ncbi.nlm.nih.gov/32759369
Autor:
D'Arice Carter, Joseph D. Pescrille, G. William Basinger, Edson X. Albuquerque, Malcolm V. Lane, William P. Fawcett, Edna F. R. Pereira, Yasco Aracava
The present study was designed to evaluate the effectiveness of galantamine administered orally as a pre-treatment to mitigate the acute toxicity of 4.0xLD50 soman in Cynomolgus monkeys post-treated with atropine, 2-PAM, and midazolam. Pharmacokineti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067429e8d3d94b59889aeabb806d84f7
https://doi.org/10.1101/2020.02.03.932798
https://doi.org/10.1101/2020.02.03.932798
Autor:
Niamh X. Cawley, Saravana R. K. Murthy, Wensheng Li, Jenny Bhupatkar, Yoke Peng Loh, Yong Cheng, Malcolm V. Lane, Istvan Merchenthaler, E. Thouennon
Publikováno v:
Endocrinology. 154:3284-3293
Prolonged chronic stress causing elevated plasma glucocorticoids leads to neurodegeneration. Adaptation to stress (allostasis) through neuroprotective mechanisms can delay this process. Studies on hippocampal neurons have identified carboxypeptidase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e720f5235793eb74e84d957719ee8c
https://doi.org/10.1210/en.2013-1118
https://doi.org/10.1210/en.2013-1118
Autor:
Angela Brodie, Vien Nguyen, Istvan Merchenthaler, Laszlo Prokai, Malcolm V. Lane, Katalin Prokai-Tatrai, Gauri Sabnis
Publikováno v:
Scientific Reports
Estrogen deprivation has a profound effect on the female brain. One of the most obvious examples of this condition is hot flushes. Although estrogens relieve these typical climacteric symptoms, many women do not want to take them owing to unwanted si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f917f162c7c787630bdb7949b4bd7c3
Autor:
Lan Xiao, Y. Peng Loh, P. Selvaraj, Malcolm V. Lane, Istvan Merchenthaler, Saravana R. K. Murthy, Niamh X. Cawley, Cheol Woo Lee, Sohyun Ahn
Publikováno v:
Stem cells (Dayton, Ohio). 35(3)
Embryonic neurodevelopment involves inhibition of proliferation of multipotent neural stem cells (NSCs) followed by differentiation into neurons, astrocytes and oligodendrocytes to form the brain. We have identified a new neurotrophic factor, NF-α1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a21adce0c8146412dd2dbc67eaf36e
https://pubmed.ncbi.nlm.nih.gov/27709799
https://pubmed.ncbi.nlm.nih.gov/27709799