Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Malcolm Tree"'
Autor:
Gillian M. Mcilwaine, James J. Morton, Anthony F. Lever, Robert Fraser, J. Ian S. Robertson, Ronald J. Weir, Robert W. Logan, J. Brown Jehoiada, Malcolm Tree
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 40:108-115
Plasma concentrations of renin, reninsubstrate, angiotensin II and aldosterone were measured in normal pregnant women at various stages of gestation and postpartum. The mean circulating levels of renin-substrate, angiotensin II and aldosterone increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55469e998f17c0be415f0928139e251c
https://doi.org/10.1210/jcem-40-1-108
https://doi.org/10.1210/jcem-40-1-108
Autor:
David J. Webb, James J. Morton, M Szelke, Per Manhem, J. Ian S. Robertson, Brenda J. Leckie, J. J. Brown, Malcolm Tree, Anthonr F. Lever
Publikováno v:
Biochemical Society Transactions. 12:948-951
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b398f40b96323279227158bfe015735e
https://doi.org/10.1042/bst0120948
https://doi.org/10.1042/bst0120948
Autor:
Michael Szelke, Malcolm Tree, Brenda J. Leckie, D Michael Jones, Butrus Atrash, Sheila Beattie, Brian Donovan, Allan Hallett, Maria Hughes, Anthony F. Lever, James J. Morton, Javier Sueiras-Diaz
Publikováno v:
Journal of Hypertension. 3:13-18
H.261, a new transition state inhibitor of human renin with an IC50 of 6.9 X 10(-10) M, was given by intravenous infusion to six anaesthetized baboons. The inhibitor was infused first at 0.1 mumol/kg/h for 15 min, then at 1.0 mumol/kg/h for a further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaacaf2a227ceec7e0b9f9e5f3dee5b7
https://doi.org/10.1097/00004872-198502000-00003
https://doi.org/10.1097/00004872-198502000-00003
Autor:
Malcolm Tree, Kenneth MacArthur, Gordon Inglis, Brenda Leckie, Anthony F. Lever, James J. Morton, Michael Szelke
Publikováno v:
Journal of Hypertension. 7:S51-S55
The renin inhibitor H77 and the angiotensin I converting enzyme (ACE) inhibitor captopril were compared in separate experiments with infusion of 5% dextrose as a control for the effects on plasma angiotensin II (Ang II) concentration, arterial pressu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f467c2baeddd4ab95d4dae085881c67b
https://doi.org/10.1097/00004872-198904002-00012
https://doi.org/10.1097/00004872-198904002-00012
Autor:
A.Mark Richards, Piero Montorsi, Malcolm Tree, G. Tonolo, Jorge Polónia, J. Ian S. Robertson, Brenda J. Leckie
Publikováno v:
The American Journal of Medicine. 84:112-118
The relationship between endogenous plasma concentrations of atrial natriuretic peptide and renin was examined in resting normal subjects and patients with cardiac impairment. To test the hypothesis that atrial natriuretic peptide inhibits renin secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c18cc06daeb0910fea25a424b1c137
https://doi.org/10.1016/0002-9343(88)90214-8
https://doi.org/10.1016/0002-9343(88)90214-8
Autor:
Malcolm Tree, Butrus Atrash, Michael Szelke, Brenda J. Leckie, James J. Morton, M Hughes, A Hallett, Brian Donovan, D. Michael Jones, John Gamble, Anthony F. Lever
Publikováno v:
Journal of Hypertension. 1:399-403
A new inhibitor of human renin (H. 189) is described. It is a decapeptide analogue of human renin substrate with the amino acid, statine, substituted for leucine in the scissile bond. Its inhibitory potency as shown by IC50 is 1.0 X 10(-8) M with hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df42c32e3986047e0f9c5a6e728142e9
https://doi.org/10.1097/00004872-198312000-00013
https://doi.org/10.1097/00004872-198312000-00013
Publikováno v:
The American journal of cardiology. 49(6)
Infusion of captopril at 20, 200, 2,000 and 6,000 micrograms/kg/hour into sodium-depleted conscious dogs produced a rapid, dose-dependent decrease in blood pressure and plasma angiotensin II and III, maximal suppression being achieved at 200 microgra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3eaa719e889f3f8ffc4d8808a897e7
https://pubmed.ncbi.nlm.nih.gov/7041583
https://pubmed.ncbi.nlm.nih.gov/7041583
Publikováno v:
Endocrinology. 103(4)
Circulating levels of [des-Asp1]angiotensin II ([des-Asp1]-AII), angiotensin II (AII), and aldosterone were measured in five conscious beagle dogs before and during iv infusion of [des-Asp1]AII at rates of 3, 6, 12, and 24 ng/kg/min. The animals were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f1f31d9e54a3ab0637b6f7b751039c
https://pubmed.ncbi.nlm.nih.gov/744159
https://pubmed.ncbi.nlm.nih.gov/744159
Publikováno v:
Journal of hypertension. 6(12)
A method for trypsin-activation of dog plasma inactive renin is described. Liquid phase trypsin (final concentration 6.7 mg/ml) was used and the reaction was stopped after 2 min at 4 degrees C by soybean trypsin inhibitor (13 mg/ml). Renin was measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86a7f70014620fda8c77ed79f2eb559
https://pubmed.ncbi.nlm.nih.gov/3065412
https://pubmed.ncbi.nlm.nih.gov/3065412
Autor:
Malcolm Tree, Gordon D. Hay, J. Ian S. Robertson, Ben H. Douglas, James J. Morton, J. J. Brown, M. Gary Nicholls, Anthony F. Lever, Robert Fraser
Publikováno v:
Endocrinology. 102(2)
The possibility that the responsiveness of plasma aldosterone concentration to angiotensin II alters with changes in sodium balance was investigated in male beagle dogs under conditions of controlled sodium and potassium intake. Angiotensin II was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748054c63bcb43b0a3c403e6f6bad36b
https://pubmed.ncbi.nlm.nih.gov/743970
https://pubmed.ncbi.nlm.nih.gov/743970