Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Malcolm P. Huestis"'
Publikováno v:
The Journal of Organic Chemistry. 86:6937-6942
The cross-coupling of S-aryl and S-alkyl potassium thiomethyltrifluoroborates with aryl and heteroaryl bromides is reported via photoredox/nickel dual catalysis. The transformation is achieved under mild conditions with commercially available or read
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd470f0df15b7de0a30ce257d616ad83
https://doi.org/10.1021/acs.joc.1c00347
https://doi.org/10.1021/acs.joc.1c00347
Autor:
Darlene Dela Cruz, Mark Merchant, Frances Shanahan, Christopher J. Sneeringer, Paul Gibbons, Shiva Malek, Michael Siu, Matthew R. Durk, Weiru Wang, John Moffat, Jianping Yin, Thomas Hunsaker, Liu Wendy, Dennis Leung, Ivana Yen, Charles Eigenbrot, Joachim Rudolph, Christine S Muli, Hank La, Brendan T. Parr, Antonio G. DiPasquale, Malcolm P. Huestis, Alberto Gobbi, Christine Orr
Publikováno v:
Journal of Medicinal Chemistry. 64:3940-3955
Optimization of a series of aryl urea RAF inhibitors led to the identification of type II pan-RAF inhibitor GNE-0749 (7), which features a fluoroquinazolinone hinge-binding motif. By minimizing reliance on common polar hinge contacts, this hinge bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5caf4fa1983e44c0d9c529885c02901c
https://doi.org/10.1021/acs.jmedchem.0c02085
https://doi.org/10.1021/acs.jmedchem.0c02085
Autor:
Samuel Aubert-Nicol, Jean-Philippe Leclerc, Arun Yadav, Robin Larouche-Gauthier, Koilpitchai Sivamuthuraman, Malcolm P. Huestis
Publikováno v:
European Journal of Organic Chemistry. 2021:396-399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6159cbf94feffc7dd2f24e0f33cfd2e9
https://doi.org/10.1002/ejoc.202001584
https://doi.org/10.1002/ejoc.202001584
Autor:
Malcolm P, Huestis, Jack A, Terrett
Publikováno v:
Nature chemistry. 14(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd4355bd313f38ac3d37d62195123daa
https://pubmed.ncbi.nlm.nih.gov/35087220
https://pubmed.ncbi.nlm.nih.gov/35087220
Autor:
Ena Ladi, Matthew R. Durk, Craig Stivala, Michael Blaesse, Malcolm P. Huestis, Seth F. Harris, Daniels Blake, Christine Everett, Rajita Pappu, Stefan Steinbacher, Martin Augustin, Steven T. Staben, Michael Siu, Hans E. Purkey, Celine Eidenschenk
Publikováno v:
Journal of Medicinal Chemistry. 62:7032-7041
The pan-proteasome inhibitor bortezomib demonstrated clinical efficacy in off-label trials of Systemic Lupus Erythematosus. One potential mechanism of this clinical benefit is from the depletion of pathogenic immune cells (plasmablasts and plasmacyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3714c93322d7d7c47334f2c0ee7068e0
https://doi.org/10.1021/acs.jmedchem.9b00509
https://doi.org/10.1021/acs.jmedchem.9b00509
Autor:
Malcolm P, Huestis, Darlene, Dela Cruz, Antonio G, DiPasquale, Matthew R, Durk, Charles, Eigenbrot, Paul, Gibbons, Alberto, Gobbi, Thomas L, Hunsaker, Hank, La, Dennis H, Leung, Wendy, Liu, Shiva, Malek, Mark, Merchant, John G, Moffat, Christine S, Muli, Christine J, Orr, Brendan T, Parr, Frances, Shanahan, Christopher J, Sneeringer, Weiru, Wang, Ivana, Yen, Jianping, Yin, Michael, Siu, Joachim, Rudolph
Publikováno v:
Journal of medicinal chemistry. 64(7)
Optimization of a series of aryl urea RAF inhibitors led to the identification of type II pan-RAF inhibitor GNE-0749 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::752defb2c13d02753ec2386945c69621
https://pubmed.ncbi.nlm.nih.gov/33780623
https://pubmed.ncbi.nlm.nih.gov/33780623
Autor:
Malcolm P. Huestis
Publikováno v:
The Journal of Organic Chemistry. 81:12545-12552
The rhodium(III) catalyst tris(acetonitrile)pentamethylcyclopentadienylrhodium(III) hexafluoroantimonate ([Cp*Rh(MeCN)3](SbF6)2) reacts with 1-(2H)-phthalazinones to promote a C–H functionalization event at C8. Preparation of a set of compounds ari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a1beff371469934fb3d4c6022aa854
https://doi.org/10.1021/acs.joc.6b02522
https://doi.org/10.1021/acs.joc.6b02522
Autor:
Arun Yadav, Koilpitchai Sivamuthuraman, Samuel Aubert-Nicol, Malcolm P. Huestis, Robin Larouche-Gauthier, Jean-Philippe Leclerc
Publikováno v:
European Journal of Organic Chemistry. 2021:325-325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a41884c725a3d931144c287c761c5c6
https://doi.org/10.1002/ejoc.202001667
https://doi.org/10.1002/ejoc.202001667
Autor:
Liu Wendy, Danial Beaudry, Remy Angelaud, Malcolm P. Huestis, Francis Gosselin, Diane E. Carrera, Jie Xu, Michael Siu
Publikováno v:
Tetrahedron Letters. 61:152430
A practical fit-for-purpose synthesis of dual leucine zipper kinase (DLK) inhibitor GNE-834 (1) was developed. The key C C bond was constructed via a Suzuki–Miyaura cross-coupling of iodopyrazole 2 and pyridine boronic ester 3 to afford ketone 12.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d90154452130d68422ca859c4621bcce
https://doi.org/10.1016/j.tetlet.2020.152430
https://doi.org/10.1016/j.tetlet.2020.152430
Autor:
Heng Chen, Malcolm P. Huestis
Publikováno v:
ChemCatChem. 7:743-746
The development of a benzylic amine directed ortho-sulfonamidation of aryl CH bonds with sulfonyl azides was investigated. The combination of a commercially available iridium(III) complex with a silver salt gave rise to an active manifold capable of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4fec367cecc12d32c59413f2c65df1
https://doi.org/10.1002/cctc.201402944
https://doi.org/10.1002/cctc.201402944