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Publikováno v:
The Open Clinical Trials Journal. 3:26-31
Phase I and early Phase II studies generally have the aim of establishing the safety, tolerability and pharmacokinetics of one or more doses and formulations. Traditionally many of these studies have tended to be conducted at a single site so that th
Publikováno v:
Contemporary clinical trials. 31(4)
Trials of many (>2) treatments are common, particularly double-blind dose finding trials in Phase IIb where trials of four or more treatments are often seen. Such trials will almost certainly be conducted at multiple centres given the sponsor's desir