Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Malcolm L. Meeson"'
1
BASE INDUCED REACTION OF AN AZETIDIN-2-ONE: FORMATION OF A NOVEL [1,4]-DIAZEPINEDIONE
Autor: Dashyant Dhanak, Malcolm L. Meeson, Richard L. Elliott, Deirdre M. B. Hickey, Andrew D. Shore, R. Curtis Haltiwanger
Publikováno v: Synthetic Communications. 31:2713-2718
A mild, base mediated conversion of an azetidin-2-one to the [1,4]-diazapinedione system is reported and a putative mechanistic pathway is proposed.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ea8a14b281bd7446f9a505f96b5296d
https://doi.org/10.1081/scc-100105399
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3
Reversible inhibitors of the gastric (H+/K+)-ATPase. 3. 3-Substituted-4-(phenylamino)quinolines
Autor: Leach Colin Andrew, David R. Reavill, Kenneth Wiggall, Colin J. Theobald, David J. Keeling, Robert John Ife, Thomas Henry Brown, Malcolm L. Meeson, Michael E. Parsons
Publikováno v: Journal of Medicinal Chemistry. 35:3413-3422
Previously, gastric (H+/K+)-ATPase inhibitors such as 2 have been prepared as analogues of 1a on the presumption that the 3-carbethoxy substituent plays a key role in establishing the orientation of the 4-arylamino group. In this paper we explore fur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cebd31e4331d8b5aab573022f2e5ce
https://doi.org/10.1021/jm00096a018
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4
CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound
Autor: Emma K. Dodds, Jayneeta Gohil, Robert John Ife, Ian Thomson Forbes, Pieter H. E. Groot, Kitty Moores, Theo A. Berkhout, Deirdre M. B. Hickey, David Gwyn Cooper, Martin Stockley, Malcolm L. Meeson
Publikováno v: Bioorganicmedicinal chemistry letters. 10(16)
A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is also achieved.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989de0004444e8338e8626d3a06ea554
https://pubmed.ncbi.nlm.nih.gov/10969972
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5
Reversible inhibitors of the gastric (H+/K+)-ATPase. 5. Substituted 2,4-diaminoquinazolines and thienopyrimidines
Autor: Leach Colin Andrew, David J. Keeling, Colin J. Theobald, Malcolm L. Meeson, Robert John Ife, Michael E. Parsons, Peter Blurton, Thomas Henry Brown
Publikováno v: Journal of medicinal chemistry. 38(14)
Quinazolines bearing a secondary 4-(arylamino) substituent demonstrate an SAR for inhibition of the gastric (H + /K + )-ATPase different from the previously described 3-acylquinolines, suggesting that, although these compounds are also K + -competiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4916b337cd6a2d8d714e94e54e26f02
https://pubmed.ncbi.nlm.nih.gov/7629814
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6
Non-basic histamine H1-antagonists. I. Synthesis and biological evaluation of some substituted 2-(2-pyridylaminoalkylamino) pyrimidones and related compounds
Autor: Michael E. Parsons, Carol A. Harvey, C. Robin Ganellin, Malcolm L. Meeson, Brian Peter Slingsby, Robert John Ife, Keith W Catchpole, Graham J. Durant, Colin J. Theobald, David A. A. Owen
Publikováno v: European Journal of Medicinal Chemistry. 24:249-257
Using the combined H 1 /H 2 -receptor histamine antagonist, icotidine (SK&F 93319, 5b ) as a starting point, a series of pyridylaminoalkylaminopyrimidones has been evaluated as potential selective H 1 -receptor antagonists with low ability to penetra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a3811515df5960d6330aafa383105c4
https://doi.org/10.1016/0223-5234(89)90006-8
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7
2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity
Autor: Robert John Ife, Catherine A. Dyke, Eugene Meenan, David J. Keeling, Anthony H. Underwood, Colin J. Theobald, Carolyn A. Price, Michael E. Parsons, Malcolm L. Meeson
Publikováno v: Journal of Medicinal Chemistry. 32:1970-1977
The benzimidazole sulfoxide class of antisecretory H+/K+-ATPase inhibitors need to possess high stability under neutral physiological conditions yet rearrange rapidly at low pH to the active sulfenamide 2. Since the initial reaction involves internal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9575bd815ecd39e34bd813afcef7ec7
https://doi.org/10.1021/jm00128a046
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