Výsledky vyhledávání - "Malcolm L Watson"

Akademický článek

Zingerone alleviates the delayed ventricular repolarization and AV conduction in diabetes: Effect on cardiac fibrosis and inflammation.

Autor: Hany M El-Bassossy, Wafaa S Al-Thubiani, Ahmed A Elberry, Mohammad I Mujallid, Salah A Ghareib, Ahmad S Azhar, Zainy M Banjar, Malcolm L Watson

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0189074 (2017)

The study aims to analyse the action of zingerone in diabetes-related cardiac arrhythmias.Diabetes was induced by streptozocin while treatment groups received 20 mg/kg zingerone daily. Following extra seven weeks, electrocardiography, extraction of b

Externí odkaz: https://doaj.org/article/b31709dd1c8145ed8412ef37b1538cc0

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Akademický článek

Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung: evidence for a role in determining morphogenic properties of FGF7.

Autor: Edward Carter, Gabriela Miron-Buchacra, Silvia Goldoni, Henry Danahay, John Westwick, Malcolm L Watson, David Tosh, Stephen G Ward

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113555 (2014)

Branching morphogenesis is a critical step in the development of many epithelial organs. The phosphoinositide-3-kinase (PI3K) pathway has been identified as a central component of this process but the precise role has not been fully established. Here

Externí odkaz: https://doaj.org/article/38d6a95452a54b9ca5345eb99a33bc87

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Staphylococcus aureus products subvert the Burkholderia cenocepacia-induced inflammatory response in airway epithelial cells

Autor: Yuan Ji, Malcolm L. Watson, Albert Bolhuis

Publikováno v: Ji, Y, Bolhuis, A & Watson, M L 2019, ' Staphylococcus aureus products subvert the Burkholderia cenocepacia-induced inflammatory response in airway epithelial cells ', Journal of Medical Microbiology, vol. 68, no. 12, pp. 1813-1822 . https://doi.org/10.1099/jmm.0.001100

Introduction. Chronic pulmonary infection is associated with colonization with multiple micro-organisms but host-microbe and microbe-microbe interactions are poorly understood.Aim. This study aims to investigate the differences in host responses to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7f383b2dc0f82dfd34570929e47406
https://doi.org/10.1099/jmm.0.001100

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Arginase overexpression and NADPH oxidase stimulation underlie impaired vasodilation induced by advanced glycation end products

Autor: Thikryat Neamatallah, Amani T. Abushareb, Hany M. El-Bassossy, Khadijah S. Balamash, Malcolm L. Watson

Publikováno v: El-bassossy, H M, Neamatallah, T, Balamash, K S, Abushareb, A T & Watson, M L 2018, ' Arginase overexpression and NADPH oxidase stimulation underlie impaired vasodilation induced by advanced glycation end products ', Biochemical and Biophysical Research Communications, vol. 499, no. 4, pp. 992-997 . https://doi.org/10.1016/j.bbrc.2018.04.036

Background Advanced glycation endproducts (AGEs) play a major role in the development of many vascular complications that are mediated by endothelial dysfunction. The present work aimed to investigate the mechanism by which AGEs impair vasodilation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f347dacbe9f5ff1977db3fa811ab976b
https://pubmed.ncbi.nlm.nih.gov/29627571

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6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation

Autor: Salah A. Ghareib, Malcolm L. Watson, Ahmed A. Elberry, Hany M. El-Bassossy, Ahmad S. Azhar, Zainey Mohammed Banjar

Publikováno v: Drug Design, Development and Therapy
Ghareib, S A, El-Bassossy, H M, Elberry, A A, Azhar, A, Watson, M L & Banjar, Z M 2015, ' 6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation ', Drug Design, Development and Therapy, vol. 9, pp. 6019-6026 . https://doi.org/10.2147/DDDT.S94346

Salah A Ghareib,1 Hany M El-Bassossy,1,2 Ahmed A Elberry,3,4 Ahmad Azhar,5 Malcolm L Watson,6 Zainy Mohammed Banjar7 1Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; 2Department of Phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c3705b15cd7d794bebd3a1c20018337
http://europepmc.org/articles/PMC4644177

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Cardioprotection by 6-gingerol in diabetic rats

Autor: Zainey Mohammed Banjar, Malcolm L. Watson, Hany M. El-Bassossy, Salah A. Ghareib, Ahmed A. Elberry, Ahmad S. Azhar

Publikováno v: El-Bassossy, H M, Elberry, A A, Ghareib, S A, Azhar, A, Banjar, Z M & Watson, M L 2016, ' Cardioprotection by 6-gingerol in diabetic rats ', Biochemical and Biophysical Research Communications, vol. 477, no. 4, pp. 908-914 . https://doi.org/10.1016/j.bbrc.2016.06.157

The current study was conducted to evaluate the effect of 6-gingerol (6G) on cardiac complications in streptozotocin (STZ)-induced diabetic (DM) rats. STZ-induced DM rats (single 50 mg/kg i.p. injection, 15 days prior to drug treatment) or time-match

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54d041eae3bb8a878071b48ba99cb64
https://pubmed.ncbi.nlm.nih.gov/27378426

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Expression and agonist responsiveness of CXCR3 variants in human T lymphocytes

Autor: Malcolm L. Watson, Andrew J. McKnight, Zoë Johnson, Anna Korniejewska, Stephen G. Ward

Publikováno v: Immunology. 132:503-515

The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 are involved in variety of inflammatory disorders including multiple sclerosis, rheumatoid arthritis, psoriasis and sarcoidosis. Two alternatively spliced variants of the human CXC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eae6b65c3e54fa00ec5be9dd9cbfd752
https://doi.org/10.1111/j.1365-2567.2010.03384.x

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Zingerone alleviates the delayed ventricular repolarization and AV conduction in diabetes: Effect on cardiac fibrosis and inflammation

Autor: Zainy M. Banjar, Salah A. Ghareib, Mohammad I. Mujallid, Malcolm L. Watson, Ahmad S. Azhar, Wafaa S. Al-Thubiani, Hany M. El-Bassossy, Ahmed A. Elberry

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0189074 (2017)

Background The study aims to analyse the action of zingerone in diabetes-related cardiac arrhythmias. Methods Diabetes was induced by streptozocin while treatment groups received 20 mg/kg zingerone daily. Following extra seven weeks, electrocardiogra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d56267b0d02cac0c19b96d8871bda9
https://doi.org/10.1371/journal.pone.0189074

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Voltage-independent calcium channels mediate lipopolysaccharide-induced hyporeactivity to endothelin-1 in the rat aorta

Autor: Sergey V. Smirnov, Mohammed S. El-Awady, Malcolm L. Watson

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 296:H1408-H1415

The roles of intracellular calcium concentration ([Ca2+]i) and Ca2+sensitization in lipopolysaccharide (LPS)-induced vascular smooth muscle (VSM) hyporesponsiveness are incompletely understood. To investigate these roles, contraction responses to end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7152924fcc817ab24f5f0cfd0c0a268a
https://doi.org/10.1152/ajpheart.01305.2008

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Desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta

Autor: Mohammed S. El-Awady, Malcolm L. Watson, Sergey V. Smirnov

Publikováno v: British Journal of Pharmacology. 155:1164-1173

Background and purpose: To investigate the function of soluble guanylyl cyclase (sGC)/3′,5′-cyclic guanosine monophosphate (cGMP) pathway in lipopolysaccharide (LPS)-induced changes in vascular reactivity of rat isolated pulmonary artery and aort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52b2147abc48243d714f5c3a23d17704
https://doi.org/10.1038/bjp.2008.358

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