Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Malcolm Hoshi"'
Autor:
Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that
Externí odkaz:
https://doaj.org/article/85a3e4c0115748e58575917074c2df76
Publikováno v:
HeartRhythm Case Reports, Vol 1, Iss 4, Pp 201-205 (2015)
Externí odkaz:
https://doaj.org/article/5ccba276c3d547a6afe35bd9b8c54a00
Publikováno v:
Current Emergency and Hospital Medicine Reports. 6:79-85
This review explores data from the past 5 years with regard to HIV testing and diagnosis in the emergency department, as well downstream linkage to care and several adjuvant approaches. We offer perspectives on futures directions for care. There are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a65ee88dac09d9010ab697cb9941cb0
https://doi.org/10.1007/s40138-018-0161-x
https://doi.org/10.1007/s40138-018-0161-x
Autor:
Malcolm Hoshi, Xiaoping Wan, Ankur Jain, Krekwit Shinlapawittayatorn, Taekjip Ha, Isabelle Deschenes, Haiyan Liu, Céline Marionneau, Eckhard Ficker, Jérôme Clatot
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Fast opening and closing of voltage-gated sodium channels are crucial for proper propagation of the action potential through excitable tissues. Unlike potassium channels, sodium channel α-subunits are believed to form functional monomers. Yet, an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::476e69ef1e5cadd6429bf2bffe0a1203
http://europepmc.org/articles/PMC5727259
http://europepmc.org/articles/PMC5727259
Autor:
Malcolm Hoshi, Krekwit Shinlapawittayatorn, Eckhard Ficker, Isabelle Deschenes, Xiaoping Wan, Haiyan Liu, Jérôme Clatot
Publikováno v:
Circulation. 132
Introduction: Mutations in SCN5A, the gene encoding for the cardiac sodium channel, produce alterations of the cardiac action potential that lead to life-threatening arrhythmias such as Long QT Syndrome (LQT3) and Brugada Syndrome (BrS). The conventi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c9d0d3a51631fbd74a4e2fe9b6c7d27
https://doi.org/10.1161/circ.132.suppl_3.14602
https://doi.org/10.1161/circ.132.suppl_3.14602
Autor:
Xiaoping Wan, Sam Chai, Isabelle Deschenes, Malcolm Hoshi, Xi X. Du, Krekwit Shinlapawittayatorn, Haiyan Liu, Eckhard Ficker
Publikováno v:
Circulation. Cardiovascular genetics. 7(2)
Background— Brugada syndrome (BrS) is an arrhythmogenic disorder that has been linked to mutations in SCN5A, the gene encoding for the pore-forming α-subunit of the cardiac sodium channel. Typically, BrS mutations in SCN5A result in a reduction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699ed277f696f1ec525659757027c435
https://pubmed.ncbi.nlm.nih.gov/24736849
https://pubmed.ncbi.nlm.nih.gov/24736849
Autor:
Jeffrey R. Schelling, Malcolm Hoshi, Raymond C. Harris, Ashraf El-Meanawy, Shenaz Khan, Eckhard Ficker, Isabelle Deschenes, Bassam G. Abu Jawdeh, Monu Goel, Mark D. Parker, Krekwit Shinlapawittayatorn, Satya P. Yadav, William P. Schilling, Michelle Puchowicz
Chronic kidney disease progression can be predicted based on the degree of tubular atrophy, which is the result of proximal tubule apoptosis. The Na+/H+ exchanger NHE1 regulates proximal tubule cell survival through interaction with phosphatidylinosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c605c026becc8e0d9cd6bcb6e4f6efa
https://europepmc.org/articles/PMC3934167/
https://europepmc.org/articles/PMC3934167/
Wild-Type Sodium Channels and ‘Atypical' Brugada Syndrome Mutants Interact through C-Terminal Region
Autor:
Malcolm Hoshi
Publikováno v:
Biophysical Journal. 104:133a
Introduction: Brugada syndrome (BrS) is an inherited cardiac disorder that can be caused by mutations in the cardiac sodium channel gene resulting in a reduction of sodium currents. However, several ‘atypical’ sodium channel mutations identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db350b7a59dc9b27c5a46b0df484e8da
https://doi.org/10.1016/j.bpj.2012.11.761
https://doi.org/10.1016/j.bpj.2012.11.761