Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics

Autor: Stefania Di Cio, Emilie Marhuenda, Malcolm Haddrick, Julien E. Gautrot

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Microfabricated organ-on-a-chips are rapidly becoming the gold standard for the testing of safety and efficacy of therapeutics. A broad range of designs has emerged, but recreating microvascularised tissue models remains difficult in many ca

Externí odkaz: https://doaj.org/article/e389f9a68ca5476bb645cfadc3c071bb

Modeling the mechanical stiffness of pancreatic ductal adenocarcinoma

Autor: Delanyo Kpeglo, Matthew D.G. Hughes, Lorna Dougan, Malcolm Haddrick, Margaret A. Knowles, Stephen D. Evans, Sally A. Peyman

Publikováno v: Matrix Biology Plus, Vol 14, Iss , Pp 100109- (2022)

Despite improvements in the understanding of disease biology, pancreatic ductal adenocarcinoma (PDAC) remains the most malignant cancer of the pancreas. PDAC constitutes ∼95% of all pancreatic cancers, and it is highly resistant to therapeutics. Th

Externí odkaz: https://doaj.org/article/1fac1be2a17a44cbbc18649805505c61

A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids

Autor: Malcolm Haddrick, Rachel Harvey, Niels Fertig, Matthew P. Burnham, Rebecca Sargeant

Publikováno v: SLAS discovery : advancing life sciences RD. 26(3)

Cardiomyocytes (CMs) derived from induced pluripotent stem cells (iPSCs) provide an in vitro model of the human myocardium. Complex 3D scaffolded culture methods improve the phenotypical maturity of iPSC-CMs, although typically at the expense of thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aea3c1b4a60cc19464866dd255d476f
https://pubmed.ncbi.nlm.nih.gov/33283596

Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumour drug accumulation and limiting bioavailability and toxicity in normal tissues

Autor: Sally A. Peyman, Malcolm Haddrick, William Townley, Michael Fairclough, Elizabeth M. A. Valleley, Nicola Ingram, Antonia Wierzbicki, Richard J. Bushby, Radwa H. Abou-Saleh, Stephen D. Evans, Pamela F. Jones, Gemma Marston, Darren Treanor, Milene Volpato, Antonia Charalambous, Juliana Maynard, Neil H. Thomson, Laura E. McVeigh, J. Anthony Evans, Jorge L Jimenez-Macias, A Wright, P. Louise Coletta, Peter B Simpson, Benjamin R. G. Johnson, Steven Freear, Alexander F. Markham, James R. McLaughlan, Paul M. Loadman

Publikováno v: Fairclough, M 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumour drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 4 . https://doi.org/10.7150/thno.49670
Ingram, N, McVeigh, L E, Abou-Saleh, R H, Maynard, J, Peyman, S A, McLaughlan, J R, Fairclough, M, Marston, G, Valleley, E M A, Jimenez-Macias, J L, Charalambous, A, Townley, W, Haddrick, M, Wierzbicki, A, Wright, A, Volpato, M, Simpson, P B, Treanor, D E, Thomson, N H, Loadman, P M, Bushby, R J, Johnson, B R G, Jones, P F, Evans, J A, Freear, S, Markham, A F, Evans, S D & Coletta, P L 2020, ' Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues ', Theranostics, vol. 10, no. 24, pp. 10973-10992 . https://doi.org/10.7150/thno.49670
Theranostics

Most cancer patients receive chemotherapy at some stage of their treatment which makes improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large numbers of potent anti-cancer agents being developed, a major obstacle to cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8743562efc9f20857e1d1305e425ca8f
https://www.research.manchester.ac.uk/portal/en/publications/ultrasoundtriggered-therapeutic-microbubbles-enhance-the-efficacy-of-cytotoxic-drugs-by-increasing-circulation-and-tumour-drug-accumulation-and-limiting-bioavailability-and-toxicity-in-normal-tissues(d99d292e-9ff7-4039-a343-5bfeafca0d06).html

A novel, label-free system to interrogate the function and 3D phenotype of iPSC cardiomyocyte co-culture spheroids for discovery applications

Autor: Ulrich Thomas, Matthew P. Burnham, Niels Fertig, Rachel Harvey, Malcolm Haddrick

Publikováno v: Journal of Pharmacological and Toxicological Methods. 93:161-162

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88b7924c3969327425fc72a1a329d7de
https://doi.org/10.1016/j.vascn.2018.01.526