Výsledky vyhledávání - "Malcolm H. Goyns"

Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span

Autor: Brian J. Merry, Malcolm H. Goyns, Austin J. Kirk

Publikováno v: Mechanisms of Ageing and Development. 129:341-348

Dietary restriction feeding extends survival in a range of species but a detailed understanding of the underlying mechanism is lacking. There is interest therefore in identifying a more targeted approach to replicate this effect on survival. We repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa20dcafb71f1db302e11b3aa6124403
https://doi.org/10.1016/j.mad.2008.04.004

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High level expression of N-acetylgluosamine-6-O-sulfotransferase is characteristic of a subgroup of paediatric precursor-B acute lymphoblastic leukaemia

Autor: Georgina Timson, Malcolm H. Goyns, Iain Magrath, Marina I. Gutiérrez, Kishor Bhatia, Sri Banavali

Publikováno v: Cancer Letters. 242:239-244

Microarray analysis is a powerful technology, but its impact on routine diagnosis for the near future maybe in revealing individual genes, which are useful diagnostic markers. Recently microarray analysis has identified a novel subgroup of childhood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd519ed74164910f7f5565a5ec75a8a
https://doi.org/10.1016/j.canlet.2005.11.012

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Genes, telomeres and mammalian ageing

Autor: Malcolm H. Goyns

Publikováno v: Mechanisms of Ageing and Development. 123:791-799

Although there appear to be several influences, which contribute to the ageing of mammals, the role of DNA appears to be pivotal. There is increasing evidence that oxidative damage is an important factor in producing mutations in genes, shortening te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc75656a80bb7b28a1292d5fce2f4bf
https://doi.org/10.1016/s0047-6374(01)00424-9

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Autor: Lindsay W. Lavery, Malcolm H. Goyns

Publikováno v: Biogerontology. 3:207-211

It appears that consistent changes in the levels of activity of a small cohort of genes (probably less than 1% of all active genes) occur in all mammalian cells during ageing. We have studied this phenomenon in rat liver using an optimised form of di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ebbde5697d3640ebc146dec14b5f672
https://doi.org/10.1023/a:1016251929165

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Fluorescence in situ hybridization analysis of the fos/jun ratio in the ageing brain

Autor: Malcolm H. Goyns, Brian J. Merry, Mansoor Salehi, Martin J. Barron

Publikováno v: Mechanisms of Ageing and Development. 107:61-71

We have examined the expression of the fos and jun genes in the cerebellum of the rat brain during ageing, by use of a semi-quantitative fluorescence in situ hybridization (FISH) method. In these experiments we have utilised the digital imaging capab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883f4d43ac673eaaaadc89e7207b5e76
https://doi.org/10.1016/s0047-6374(98)00137-7

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Cytogenetic Analysis of Non Hodgkin's Lymphomas by Ratio-Painting and Comparative Genomic Hybridization Reveals Unsuspected Chromosomal Abnormalities

Autor: Mohammed H. Alqahtani, John R. Goepel, David W. Hammond, Malcolm H. Goyns

Publikováno v: Leukemia & Lymphoma. 35:325-337

Cytogenetic analysis of cancer cells has proven to be a powerful tool in understanding malignant evolution and in providing clinically useful markers. In recent years the advent of new fluorescence in-situ hybridization (FISH) methods such as ratio-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b69e5ad3c70512328436b231c3bd8a0
https://doi.org/10.3109/10428199909145737

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Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes

Autor: Brian J. Merry, James E. Dunford, M. A. Charlton, W. L. Lavery, Malcolm H. Goyns, Mansoor Salehi, Davina Camargo Madeira Simoes

Publikováno v: Mechanisms of Ageing and Development. 101:73-90

It is clear that there is a genetic component associated with the ageing process. Although evolutionary theory has suggested that the activity of certain genes may facilitate ageing by favouring resource utilisation by the germ cells at the expense o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803dbfb03ab9d32a6df62a211fa22297
https://doi.org/10.1016/s0047-6374(97)00166-8

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Autor: Malcolm H. Goyns, M. A. Hodgkins, Brian J. Merry, Mansoor Salehi

Publikováno v: Experientia. 52:888-891

We have used the polymerase chain reaction (PCR)-based technique of differential display to analyse changes in gene expression during ageing of the rat brain. In this approach we have compared three young adult (6 months) with three old adult (20 mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3afa444319adb419a16644e8d2efea
https://doi.org/10.1007/bf01938876

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