Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Malcolm Gracie Semple"'
Autor:
Emily Jefferson, Christian Cole, Shahzad Mumtaz, Samuel Cox, Thomas Charles Giles, Sam Adejumo, Esmond Urwin, Daniel Lea, Calum Macdonald, Joseph Best, Erum Masood, Gordon Milligan, Jenny Johnston, Scott Horban, Ipek Birced, Christopher Hall, Aaron S Jackson, Clare Collins, Sam Rising, Charlotte Dodsley, Jill Hampton, Andrew Hadfield, Roberto Santos, Simon Tarr, Vasiliki Panagi, Joseph Lavagna, Tracy Jackson, Antony Chuter, Jillian Beggs, Magdalena Martinez-Queipo, Helen Ward, Julie von Ziegenweidt, Frances Burns, Joanne Martin, Neil Sebire, Carole Morris, Declan Bradley, Rob Baxter, Anni Ahonen-Bishopp, Paul Smith, Amelia Shoemark, Ana M Valdes, Benjamin Ollivere, Charlotte Manisty, David Eyre, Stephanie Gallant, George Joy, Andrew McAuley, David Connell, Kate Northstone, Katie Jeffery, Emanuele Di Angelantonio, Amy McMahon, Mat Walker, Malcolm Gracie Semple, Jessica Mai Sims, Emma Lawrence, Bethan Davies, John Kenneth Baillie, Ming Tang, Gary Leeming, Linda Power, Thomas Breeze, Duncan Murray, Chris Orton, Iain Pierce, Ian Hall, Shamez Ladhani, Natalie Gillson, Matthew Whitaker, Laura Shallcross, David Seymour, Susheel Varma, Gerry Reilly, Andrew Morris, Susan Hopkins, Aziz Sheikh, Philip Quinlan
Publikováno v:
Journal of Medical Internet Research, Vol 24, Iss 12, p e40035 (2022)
BackgroundCOVID-19 data have been generated across the United Kingdom as a by-product of clinical care and public health provision, as well as numerous bespoke and repurposed research endeavors. Analysis of these data has underpinned the United Kingd
Externí odkaz:
https://doaj.org/article/54ca7e259fa5437b93518def8143ad8f
Autor:
Ruth Keogh, Malcolm Gracie Semple
Publikováno v:
Lifetime Data Analysis. 29:288-317
Autor:
Innocent Gerald Asiimwe, Maria Vittoria Mancini, Malcolm Gracie Semple, Paul Morgan, Kate Megan Davies, Wendy Barclay, Matthew Siggins, Ahilanandan Dushianthan, Paul Dark, Emma Thomson, Peter Openshaw
Publikováno v:
Investigators, ISARICC & Dark, P 2022, ' Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19 ', Immunology . https://doi.org/10.1111/imm.13585
Baillie, J K 2022, ' Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19 ', Immunology . https://doi.org/10.1111/imm.13585
Baillie, J K 2022, ' Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19 ', Immunology . https://doi.org/10.1111/imm.13585
Complement, a critical defence against pathogens, has been implicated as a driver of pathology in COVID-19. Complement activation products are detected in plasma and tissues and complement blockade is considered for therapy. To delineate roles of com
Autor:
Malcolm Gracie Semple, Oleg Averkov, Alexey Zimin, Dmitri Grishin, Michael Piradov, Natalia Polekhina
Publikováno v:
Infectious diseases: News, Opinions, Training. 11:57-63
Optimising statistical power in early-stage trials and observational studies accelerates discovery and improves the reliability of results. Ideally, intermediate outcomes should be continuously distributed and lie on the causal pathway between an int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db786caae0cd3a96239d2fafc1d03ff5
https://doi.org/10.1101/2022.09.25.22280081
https://doi.org/10.1101/2022.09.25.22280081
Autor:
Emily Jefferson, Christian Cole, Shahzad Mumtaz, Sam Cox, Tom Giles, Samuel Adejumo, Esmond Urwin, Daniel Lea, Calum McDonald, Joseph Best, Erum Masood, Gordon Milligan, Jenny Johnston, Scott Horban, Ipek Birced, Christopher Hall, Aaron Jackson, Clare Collins, Sam Rising, Charlotte Dodsley, Jill Hampton, Andrew Hadfield, Roberto Santos, Simon Tarr, Vasiliki Panagi, Joseph Lavagna, Tracy Jackson, Antony Chuter, Jillian Beggs, Magdalena Martinez-Queipo, Helen Ward, Julie von Ziegenweidt, Frances Burns, Jo Martin, Neil Sebire, Carole Morris, Declan Bradley, Rob Baxter, Anni Ahonen-Bishop, Amelia Shoemark, Ana Valdes, Benjamin J Ollivere, Charlotte Manisty, David William Eyre, Stephanie Gallant, George Joy, Andrew McAuley, David W Connell, Kate Northstone, Katie JM Jeffery, Emanuele Di Angelantonio, Amy McMahon, Matthew Walker, Malcolm Gracie Semple, Jessica Mai Sims, Emma Lawrence, Bethan Davies, J Kenneth Baillie, Ming Tang, Gary Leeming, Linda Power, Thomas Breeze, Natalie Gilson, Duncan J Murray, Chris Orton, Iain Pierce, Ian Hall, Shamez Ladhani, Matthew Whitaker, Laura Shallcross, David Seymour, Susheel Varma, Gerry Reilly, Andrew Morris, Susan Hopkins, Aziz Sheikh, Philip Quinlan
BACKGROUND COVID-19 data have been generated across the UK as a by-product of clinical care and public health provision, and numerous bespoke and repurposed research endeavours. Analysis of these data has underpinned the UK’s response to the pandem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2036757b72bbe664da4877213212529e
https://doi.org/10.2196/preprints.40035
https://doi.org/10.2196/preprints.40035
Autor:
Paul Collini, Charlotte Summers, Graciela Isabel García Dorival, Andrew Ustianowski, Ryan Thwaites, Innocent Gerald Asiimwe, Lance Turtle, Thushan De Silva, Malcolm Gracie Semple, Tom Fletcher, Matthew Siggins, Patrick Lillie, Mark Lyttle, Effrossyni Gkrania-Klotsas, Ahilanandan Dushianthan, Paul Dark, David Price, Antonia Ho, Clark Russell, John Kenneth Baillie
Publikováno v:
Relph, K A, Russell, C D, Fairfield, C J, Turtle, L, De Silva, T, Siggins, M K, Drake, T M, Thwaites, R S, Abrams, S, Moore, S C, Hardwick, H E, Oosthuyzen, W, Harrison, E M, Docherty, A B, Openshaw, P J M, Baillie, J K & Semple, M G & Ho, A 2022, ' Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission ', Open forum infectious diseases, vol. 9, no. 5 . https://doi.org/10.1093/ofid/ofac179
Investigators, I S A R A E I C C C C C ISARICC & Dark, P 2022, ' Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. ', Open Forum Infectious Diseases, vol. 9, no. 5, ofac179 . https://doi.org/10.1093/ofid/ofac179
Investigators, I S A R A E I C C C C C ISARICC & Dark, P 2022, ' Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. ', Open Forum Infectious Diseases, vol. 9, no. 5, ofac179 . https://doi.org/10.1093/ofid/ofac179
Admission procalcitonin measurements and microbiology results were available for 1040 hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International Severe Acute Respiratory and Emerging Infections Consortium World Healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce07cd41416a4c1baa2b4eefe096672
http://hdl.handle.net/10044/1/96777
http://hdl.handle.net/10044/1/96777
Autor:
Daniel Fryer, Kyle Young, Malcolm Gracie Semple, Kalynn Kennon, Srinivas Murthy, Samual MacDonald
BackgroundAcute kidney injury (AKI) is one of the most common and significant problems in patients with COVID-19. However, little is known about the incidence and impact of AKI occurring in the community or early in the hospital admission. The tradit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f3e9305804f40317a3f8f212d765474
https://doi.org/10.1101/2022.03.18.22272601
https://doi.org/10.1101/2022.03.18.22272601
Autor:
Charlotte Summers, Angel Carracedo, Lucija Klarić, Malcolm Gracie Semple, Albert Tenesa, Andy Law, Erola Pairo-Castineira, John Kenneth Baillie
Pulmonary inflammation drives critical illness in Covid-19, 1;2 creating a clinically homogeneous extreme phenotype, which we have previously shown to be highly efficient for discovery of genetic associations. 3;4 Despite the advanced stage of illnes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81876181676c2a7b13255582f17c0d7
https://doi.org/10.1101/2022.03.07.22271833
https://doi.org/10.1101/2022.03.07.22271833
Autor:
Malcolm Gracie Semple
The mutational landscape of SARS-CoV-2 varies at both the dominant viral genome sequence and minor genomic variant population. An early change associated with transmissibility was the D614G substitution in the spike protein. This appeared to be accom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a3450a75e69bd7260a0be8f5054d2bc
https://doi.org/10.1101/2021.12.23.474030
https://doi.org/10.1101/2021.12.23.474030