A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.

Autor: John D Chan, John D McCorvy, Sreemoyee Acharya, Malcolm E Johns, Timothy A Day, Bryan L Roth, Jonathan S Marchant

Publikováno v: PLoS Pathogens, Vol 12, Iss 5, p e1005651 (2016)

Schistosomiasis is a tropical parasitic disease afflicting ~200 million people worldwide and current therapy depends on a single drug (praziquantel) which exhibits several non-optimal features. These shortcomings underpin the need for next generation

Externí odkaz: https://doaj.org/article/fe1f928fc89b4bd388531dfdc6587048

Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviours: A laser scanning confocal microscopy study in rats

Autor: Brian D. McAdams, Rajiv A. Kabadi, Donald A. Simone, Ratan K. Banik, Megan L. Uhelski, Malcolm E. Johns

Publikováno v: European Journal of Pain. 24:1197-1208

Background Spontaneous pain after surgical incision is a significant problem for most post-operative patients. Pain management that relies on opioids is hindered by numerous side effects, fuelling interest in non-opioid alternatives and multimodal ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b13597cc0177109da848d1ae3b4a61
https://doi.org/10.1002/ejp.1564

The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells

Autor: Timothy F. Walseth, James T. Slama, Timnit Yosef Asfaha, Malcolm E. Johns, Jonathan S. Marchant, Gihan S. Gunaratne

Publikováno v: Cell Calcium

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+) mobilizing second messenger which triggers Ca(2+) release in both sea urchin egg homogenates and in mammalian cells. The NAADP binding protein has not been identified and the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6dc8430851751bfa33be244436d826
https://pubmed.ncbi.nlm.nih.gov/31442840

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes

Autor: Silvia Ortega-Gutiérrez, Jonathan S. Marchant, Federico Camicia, Hugo R. Vaca, Mar Martín-Fontecha, Nicolás Di Siervi, Malcolm E. Johns, Ana M. Celentano, John D. Chan, Lucas Luciano Maldonado, Ana M. Gamo, Mara Cecilia Rosenzvit, Laura Kamentezky, Carlos Davio

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006267 (2018)
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
PLoS Neglected Tropical Diseases
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
E-Prints Complutense. Archivo Institucional de la UCM
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Background Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G protein coupled receptors (GPCRs) which have proved to be highly druggable target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1163ec625690449e528a87881dc05361
http://europepmc.org/articles/PMC5823469?pdf=render

Preemptive Morphine Analgesia Attenuates the Long-Term Consequences of Neonatal Inflammation in Male and Female Rats

Autor: Jamie L. LaPrairie, Malcolm E. Johns, Anne Z. Murphy

Publikováno v: Pediatric Research. 64:625-630

Despite mounting evidence on the importance of pain management in preterm infants, clinical use of analgesics in this population is limited. Our previous studies have shown that neonatal inflammation results in long-term alterations in adult somatose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84127a08e0379b43aaeff061e7e6296
https://doi.org/10.1203/pdr.0b013e31818702d4