Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Malcolm E, Johns"'
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Akademický článek
Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes.
Autor: Federico Camicia, Ana M Celentano, Malcolm E Johns, John D Chan, Lucas Maldonado, Hugo Vaca, Nicolás Di Siervi, Laura Kamentezky, Ana M Gamo, Silvia Ortega-Gutierrez, Mar Martin-Fontecha, Carlos Davio, Jonathan S Marchant, Mara C Rosenzvit
Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006267 (2018)
BACKGROUND:Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G protein coupled receptors (GPCRs) which have proved to be highly druggable target
Externí odkaz: https://doaj.org/article/f81810f8df9e410a950ba1e4bbe2e2bb
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2
Adverse effects of methylene blue in peripheral neurons: An
Autor: Megan L, Uhelski, Malcolm E, Johns, Alec, Horrmann, Sadiq, Mohamed, Ayesha, Sohail, Iryna A, Khasabova, Donald A, Simone, Ratan K, Banik
Publikováno v: Molecular pain. 18
Methylene blue (MB) is an effective treatment for methemoglobinemia, ifosfamide-induced encephalopathy, cyanide poisoning, and refractory vasoplegia. However, clinical case reports and preclinical studies indicate potentially neurotoxic activity of M
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cdde8811ee09494fc3fa2e16b6942904
https://pubmed.ncbi.nlm.nih.gov/36408567
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3
Akademický článek
A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.
Autor: John D Chan, John D McCorvy, Sreemoyee Acharya, Malcolm E Johns, Timothy A Day, Bryan L Roth, Jonathan S Marchant
Publikováno v: PLoS Pathogens, Vol 12, Iss 5, p e1005651 (2016)
Schistosomiasis is a tropical parasitic disease afflicting ~200 million people worldwide and current therapy depends on a single drug (praziquantel) which exhibits several non-optimal features. These shortcomings underpin the need for next generation
Externí odkaz: https://doaj.org/article/fe1f928fc89b4bd388531dfdc6587048
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4
Lack of relationship between epidermal denervation by capsaicin and incisional pain behaviours: A laser scanning confocal microscopy study in rats
Autor: Brian D. McAdams, Rajiv A. Kabadi, Donald A. Simone, Ratan K. Banik, Megan L. Uhelski, Malcolm E. Johns
Publikováno v: European Journal of Pain. 24:1197-1208
Background Spontaneous pain after surgical incision is a significant problem for most post-operative patients. Pain management that relies on opioids is hindered by numerous side effects, fuelling interest in non-opioid alternatives and multimodal ap
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b13597cc0177109da848d1ae3b4a61
https://doi.org/10.1002/ejp.1564
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5
Global transcriptome analysis of rat dorsal root ganglia to identify molecular pathways involved in incisional pain
Autor: Juan E. Abrahante, Ratan K. Banik, Donald A. Simone, Brian D. McAdams, Phu V. Tran, Malcolm E. Johns
Publikováno v: Molecular Pain
To develop non-opioid therapies for postoperative incisional pain, we must understand its underlying molecular mechanisms. In this study, we assessed global gene expression changes in dorsal root ganglia neurons in a model of incisional pain to ident
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9feb73f5804e44a21a0b5c856d8bc3
https://pubmed.ncbi.nlm.nih.gov/32909881
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6
The synthesis and characterization of a clickable-photoactive NAADP analog active in human cells
Autor: Timothy F. Walseth, James T. Slama, Timnit Yosef Asfaha, Malcolm E. Johns, Jonathan S. Marchant, Gihan S. Gunaratne
Publikováno v: Cell Calcium
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca(2+) mobilizing second messenger which triggers Ca(2+) release in both sea urchin egg homogenates and in mammalian cells. The NAADP binding protein has not been identified and the re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6dc8430851751bfa33be244436d826
https://pubmed.ncbi.nlm.nih.gov/31442840
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7
A screening campaign in sea urchin egg homogenate as a platform for discovering modulators of NAADP-dependent Ca
Autor: Gihan S, Gunaratne, Malcolm E, Johns, Hallie M, Hintz, Timothy F, Walseth, Jonathan S, Marchant
Publikováno v: Cell calcium. 75
The Ca(2+) mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) regulates intracellular trafficking events, including translocation of certain enveloped viruses through the endolysosomal system. Targeting NAADP-evoked Ca(
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f2db1503725c224d752a80c9f294dc28
https://pubmed.ncbi.nlm.nih.gov/30145428
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8
Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes
Autor: Silvia Ortega-Gutiérrez, Jonathan S. Marchant, Federico Camicia, Hugo R. Vaca, Mar Martín-Fontecha, Nicolás Di Siervi, Malcolm E. Johns, Ana M. Celentano, John D. Chan, Lucas Luciano Maldonado, Ana M. Gamo, Mara Cecilia Rosenzvit, Laura Kamentezky, Carlos Davio
Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 2, p e0006267 (2018)
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
PLoS Neglected Tropical Diseases
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
E-Prints Complutense. Archivo Institucional de la UCM
instname
Background Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G protein coupled receptors (GPCRs) which have proved to be highly druggable target
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1163ec625690449e528a87881dc05361
http://europepmc.org/articles/PMC5823469?pdf=render
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9
Sex differences in the activation of the spinoparabrachial circuit by visceral pain
Autor: Richard J. Traub, Shelby K. Suckow, Anne Z. Murphy, Malcolm E. Johns
Publikováno v: Physiology & Behavior. 97:205-212
Women are more sensitive to most noxious visceral stimuli, both in terms of intensity and frequency. The spinoparabrachial (spino-PBn) pathway is an essential neural circuit for the central relay of viscerosensitive information, but studies character
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9c584ec8052d7b5fd965c362ae5df2
https://doi.org/10.1016/j.physbeh.2009.02.037
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10
Preemptive Morphine Analgesia Attenuates the Long-Term Consequences of Neonatal Inflammation in Male and Female Rats
Autor: Jamie L. LaPrairie, Malcolm E. Johns, Anne Z. Murphy
Publikováno v: Pediatric Research. 64:625-630
Despite mounting evidence on the importance of pain management in preterm infants, clinical use of analgesics in this population is limited. Our previous studies have shown that neonatal inflammation results in long-term alterations in adult somatose
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84127a08e0379b43aaeff061e7e6296
https://doi.org/10.1203/pdr.0b013e31818702d4
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