Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Malcolm Duckworth"'
Autor:
Maurice K. Farmer, Derek N. Middlemiss, David A. Campbell, Anthony M. C. Brown, Menelas N. Pangalos, Malcolm Duckworth, Kathryn Ellington, Melanie J. Robbins, Gary W. Price, Andrew D. Medhurst
Publikováno v:
Genomics. 70:241-252
Orphan transporters form a growing subfamily of genes related by sequence similarity to the Na+/Cl- -dependent neurotransmitter superfamily. Using a combination of database similarity searching and cloning methods, we have identified and characterize
Autor:
Andrew D. Randall, David A. Campbell, Malcolm Duckworth, Paul R. Murdock, Helen J. Meadows, Conrad Gerald Chapman, Rosemary E. Kelsell, Gillian I. Rennie, Israel S. Gloger, Rob J. Godden
Publikováno v:
Molecular Brain Research. 82:74-83
We have isolated, by degenerate PCR, a complementary DNA encoding a novel two pore domain potassium channel. This is the 7th functional member of the human tandem pore domain potassium channel family to be reported. It has an open reading frame of 1.
Autor:
Peter Ham, J V Selkirk, Frank E. Blaney, Susannah Davies, L M Gaster, David Malcolm Duckworth, John M. Hatcher, Derek N. Middlemiss, Gary W. Price, Frank King, P. D. Slade, Jim J. Hagan, Wyman Paul Adrian, Graham Francis Joiner, Claire Roberts, Sarah Margaret Jenkins, Carol Routledge, Keith Raymond Mulholland, Riley Gj, Andrew John Jennings, B. J. Jones
Publikováno v:
Journal of Medicinal Chemistry. 41:1218-1235
5-HT1 receptors are members of the G-protein-coupled receptor superfamily and are negatively linked to adenylyl cyclase activity. The human 5-HT1B and 5-HT1D receptors (previously known as 5-HT1Dbeta and 5-HT1Dalpha, respectively), although encoded b
Autor:
Lee J. Beeley, D. Malcolm Duckworth
Publikováno v:
Drug Discovery Today. 1:474-480
Within the past few years, genomics has made a dramatic impact on the pharmaceutical industry, and it is viewed as an effective way to accelerate the discovery of pioneer drugs. In this review we describe how the application of genomics is generating
Autor:
G.A. Kennett, Christopher B. Naylor, Frank D. King, G. S. Baxter, Martyn D. Wood, Peter Ham, Saunders Dv, Thomas P. Blackburn, G. E. Jones, Ian Thomson Forbes, Frank E. Blaney, David Malcolm Duckworth, Steven Dabbs
Publikováno v:
ChemInform. 28
Publikováno v:
Tetrahedron Letters. 32:1987-1990
We report the synthesis of the glucosidic indole alkaloid cadambine (5) in 48% yield from its biological precursor secologanin (1) in an intermolecular variant of the in vivo process where chemoselective and regioselective attack by tryptamine on a 3
Publikováno v:
Current opinion in drug discoverydevelopment. 9(5)
Autor:
Christopher B. Naylor, Martyn D. Wood, Ian Thomson Forbes, Frank E. Blaney, Guy A. Kennett, Thomas P. Blackburn, Frank King, Stephen E. Clarke, Steven Mark Bromidge, Kevin M. Thewlis, Malcolm Duckworth, Peter Ham
Publikováno v:
Journal of Medicinal Chemistry. 40:3494-3496
Publikováno v:
Current opinion in drug discoverydevelopment. 8(5)
Publikováno v:
Current opinion in drug discoverydevelopment. 7(5)