Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Malcolm D McLeod"'
Autor:
Merryn Fraser, Blake Curtis, Patrick Phillips, Patrick A Yates, Kwong Sum Lam, Otto Netzel, Giel G van Dooren, Alyssa Ingmundson, Kai Matuschewski, Malcolm D McLeod, Alexander G Maier
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1515-1532 (2024)
Abstract Parasites, such as the malaria parasite P. falciparum, are critically dependent on host nutrients. Interference with nutrient uptake can lead to parasite death and, therefore, serve as a successful treatment strategy. P. falciparum parasites
Externí odkaz:
https://doaj.org/article/ff09ddd81108437faeee65fa9548788b
Autor:
Christopher C. J. Fitzgerald, Rikard Hedman, Dimanthi R. Uduwela, Bettina Paszerbovics, Adam J. Carroll, Teresa Neeman, Adam Cawley, Lance Brooker, Malcolm D. McLeod
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The study of urinary phase II sulfate metabolites is central to understanding the role and fate of endogenous and exogenous compounds in biological systems. This study describes a new workflow for the untargeted metabolic profiling of sulfated metabo
Externí odkaz:
https://doaj.org/article/5871e93fb4b641918ef1e182aeacb56c
Autor:
Matthew A. Hulverson, Ryan Choi, Deborah A. Schaefer, Dana P. Betzer, Molly C. McCloskey, Grant R. Whitman, Wenlin Huang, Sangun Lee, Andy Pranata, Malcolm D. McLeod, Kennan C. Marsh, Dale J. Kempf, Bruce E. LeRoy, Mark T. Zafiratos, Aimee L. Bielinski, Robert C. Hackman, Kayode K. Ojo, Samuel L. M. Arnold, Lynn K. Barrett, Saul Tzipori, Michael W. Riggs, Erkang Fan, Wesley C. Van Voorhis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Recent advances on the development of bumped kinase inhibitors for treatment of cryptosporidiosis have focused on the 5-aminopyrazole-4-carboxamide scaffold, due to analogs that have less hERG inhibition, superior efficacy, and strong in vitro safety
Autor:
Malcolm D. McLeod
Publikováno v:
Ghana Studies. 25:127-133
Autor:
Andy Pranata, Sean Yamada, Sumudu Weththasinghe, Karen Caldwell, Paul W. Zahra, Steven L. Karamatic, Michael G. Gardiner, Malcolm D. McLeod
Publikováno v:
Steroids. 190
Δ6-Methyltestosterone was reported as the main active ingredient of the purported "dietary supplement" Jungle Warfare. This compound is structurally similar to 17α-methyltestosterone, containing an additional Δ6 double bond, and is reported to pos
Autor:
Steven Karamatic, Andy Pranata, Blake Curtis, Karen Caldwell, Christopher C. Waller, Paul Zahra, Malcolm D. McLeod
Publikováno v:
Drug Testing and Analysis. 13:1749-1757
Samples of the "dietary supplement" Furazadrol sourced through the internet have been reported to contain the designer anabolic androgenic steroids [1',2']isoxazolo[4',5':2,3]-5α-androstan-17β-ol (furazadrol F) and [1',2']isoxazolo[4',3':2,3]-5α-a
Autor:
Christopher C. J. Fitzgerald, Christopher Bowen, Madysen Elbourne, Adam Cawley, Malcolm D. McLeod
Publikováno v:
Journal of the American Society for Mass Spectrometry. 33(7)
The identification and confirmation of steroid sulfate metabolites in biological samples are essential to various fields, including anti-doping analysis and clinical sciences. Ultra-high-performance liquid chromatography with tandem mass spectrometry
Synthesis of 3α,6β‐Dihydroxyandrostan‐17‐one 3‐Glucuronides for the Detection of Testosterone Misuse
Publikováno v:
European Journal of Organic Chemistry. 2022
Autor:
Emily Suann, Malcolm D. McLeod, Craig J. Suann, Alison K. Heather, Adam Cawley, Sumudu A. Weththasinghe, Elliot R. Cooper, Emma Sutherland, Christopher C. Waller, Lauren McClure
Publikováno v:
Drug Testing and Analysis. 12:752-762
Hemapolin (2α,3α-epithio-17α-methyl-5α-androstan-17β-ol) is a designer steroid that is an ingredient in several "dietary" and "nutritional" supplements available online. As an unusual chemical modification to the steroid A-ring could allow this
Publikováno v:
Protein Engineering, Design and Selection. 35
Steroid sulfate esters are important metabolites for anti-doping efforts in sports, pathology and research. Analysis of these metabolites is facilitated by hydrolysis using either acid or enzymatic catalysis. Although enzymatic hydrolysis is preferre