Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Malcolm D, Smith"'
Autor:
Katie Lowe, Annabelle Small, Qingxuan Song, Ling-Yang Hao, William Murray-Brown, Susanna Proudman, Malcolm D. Smith, Sunil Nagpal, Mihir D. Wechalekar
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Programmed cell death protein 1 (PD-1)-expressing T cells are expanded in individuals with established rheumatoid arthritis (RA). However, little is known about their functional role in the pathogenesis of early RA. To address this, we inves
Externí odkaz:
https://doaj.org/article/c8beaac6c2f84d4dbdb177179193cb1d
Autor:
Susanna M Proudman, Ling-Yang Hao, William Murray-Brown, Helen Weedon, Malcolm D Smith, Mihir D Wechalekar, Susan E Lester, Sunil Nagpal, Yanxia Guo, Annabelle Small, Katie Lowe, Navin L Rao
Publikováno v:
RMD Open, Vol 8, Iss 2 (2022)
Objectives Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5− T cells, termed T peripheral helper (Tph) cells, which driv
Externí odkaz:
https://doaj.org/article/f7fc10303c3b466ab3977cd24072ecdf
Autor:
William Murray-Brown, Tom D Wilsdon, Helen Weedon, Shawgi Sukumaran, Jennifer G Walker, Malcolm D Smith, Mihir D Wechalekar
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Immune checkpoint inhibitors (ICIs) are associated with rheumatic and musculoskeletal immune-related adverse events (irAEs) in 5%–20% of patients. Currently, patients refractory to corticosteroids and conventional disease-modifying antir
Externí odkaz:
https://doaj.org/article/3ff420a1c1334dfdbe3137f84bc8f0e1
Autor:
Suzanne Cole, Alice Walsh, Xuefeng Yin, Mihir D. Wechalekar, Malcolm D. Smith, Susanna M. Proudman, Douglas J. Veale, Ursula Fearon, Costantino Pitzalis, Frances Humby, Michele Bombardieri, Amy Axel, Homer Adams, Christopher Chiu, Michael Sharp, John Alvarez, Ian Anderson, Loui Madakamutil, Sunil Nagpal, Yanxia Guo
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-14 (2018)
Abstract Background Plasmablasts and plasma cells play a key role in many autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). This study was undertaken to evaluate the potential of targeting CD38 as a plasma
Externí odkaz:
https://doaj.org/article/36023e7ad5564381815500c7e7f37e9e
Autor:
Yanxia Guo, Alice M Walsh, Mary Canavan, Mihir D Wechalekar, Suzanne Cole, Xuefeng Yin, Brittney Scott, Mathew Loza, Carl Orr, Trudy McGarry, Michele Bombardieri, Frances Humby, Susanna M Proudman, Costantino Pitzalis, Malcolm D Smith, Joshua R Friedman, Ian Anderson, Loui Madakamutil, Douglas J Veale, Ursula Fearon, Sunil Nagpal
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192704 (2018)
Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficacy in multip
Externí odkaz:
https://doaj.org/article/0245b0b04ea640cd937145e897e7feff
Autor:
Alice M Walsh, Mihir D Wechalekar, Yanxia Guo, Xuefeng Yin, Helen Weedon, Susanna M Proudman, Malcolm D Smith, Sunil Nagpal
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0183928 (2017)
This study sought to investigate the genome-wide transcriptional effects of a combination of disease modifying anti-rheumatic drugs (tDMARD; methotrexate, sulfasalazine and hydroxychloroquine) in synovial tissues obtained from early rheumatoid arthri
Externí odkaz:
https://doaj.org/article/76f9ed5f606142999ff644b601a6cae9
Autor:
Anak A. S. S. K. Dharmapatni, Melissa D. Cantley, Victor Marino, Egon Perilli, Tania N. Crotti, Malcolm D. Smith, David R. Haynes
Publikováno v:
Mediators of Inflammation, Vol 2015 (2015)
Objective. To investigate the effect of Embelin, an inhibitor of X-Linked Inhibitor of Apoptosis Protein (XIAP), on inflammation and bone erosion in a collagen antibody induced arthritis (CAIA) in mice. Methods. Four groups of mice (n=6 per group) we
Externí odkaz:
https://doaj.org/article/433908350b2a4c16926ee806317f55ec
Autor:
William Murray-Brown, Yanxia Guo, Annabelle Small, Katie Lowe, Helen Weedon, Malcolm D Smith, Susan E Lester, Susanna M Proudman, Navin L Rao, Ling-Yang Hao, Sunil Nagpal, Mihir D Wechalekar
Publikováno v:
RMD Open. 8:e002563
ObjectivesProgrammed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5−T cells, termed T peripheral helper (Tph) cells, which drive
Autor:
H. Weedon, Shawgi Sukumaran, Tom D Wilsdon, William Murray-Brown, Mihir D. Wechalekar, Malcolm D. Smith, Jennifer G Walker, Susanna Proudman, Sonja Klebe
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundImmune checkpoint inhibitors (ICIs) are associated with rheumatic and musculoskeletal immune-related adverse events (irAEs) in 5%–20% of patients. Currently, patients refractory to corticosteroids and conventional disease-modifying antirh
Publikováno v:
International Journal of Rheumatology, Vol 2009 (2009)
Aim. To describe the retention rates for biological therapies in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) in a clinical setting. Methods. All patients managed in a dedicated biological therap
Externí odkaz:
https://doaj.org/article/80c52cac773d4929a8980600a392f480