Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Malcolm C. Paterson"'
Autor:
Konrad S. Famulski, Malgorzata Pienkowska, Kelly Dobler, Futwan Al-Mohanna, Malcolm C. Paterson, Reem Al-Hijailan
Publikováno v:
Oncogene. 22:471-475
Ataxia telangiectasia (AT) is a human hereditary syndrome whose underlying gene product, ataxia telangiectasia mutated (ATM) protein kinase, is involved in multiple intracellular signaling pathways. We demonstrated previously that AT fibroblasts are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000191f13250122f2d2f84dfae6bc120
https://doi.org/10.1038/sj.onc.1206167
https://doi.org/10.1038/sj.onc.1206167
Publikováno v:
Biochemistry. 41:9248-9255
Extracts of two human glioma cell lines (lacking O 6 -methylguanine DNA-methyltransferase) (i.e., A1235 and its alkylation-resistant derivative A1235-MR4) were examined for their ability to execute strand incision at different base mismatches in mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7415f91765b7a00759798c4b47cb56
https://doi.org/10.1021/bi020239n
https://doi.org/10.1021/bi020239n
Autor:
Razmik Mirzayans, Malcolm C. Paterson
Publikováno v:
Environmental and Molecular Mutagenesis. 38:191-199
Cultured cells from patients inheriting the rare cancer-prone and radiotherapy-sensitive disorder ataxia telangiectasia (AT) exhibit defects in the activation of cell-cycle checkpoints after exposure to ionizing radiation. In particular, the failure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1beb2f57719bb318952cd71600b8f7
https://doi.org/10.1002/em.1071
https://doi.org/10.1002/em.1071
Publikováno v:
Biochemical Journal. 352:443-448
FHIT (fragile histidine triad), a candidate tumour suppressor gene, has recently been identified at chromosomal region 3p14.2, and deletions of the gene have been reported in many types of human cancer. However, the biological function of the Fhit pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1183b558d37d1604daf5e2487c133f9
https://doi.org/10.1042/bj3520443
https://doi.org/10.1042/bj3520443
Publikováno v:
Cell Death & Differentiation. 6:281-289
Intracellular acidification caused by agents such as UV(C), etoposide or ceramide accompanies the progression of apoptosis. It is suggested that cellular acidosis may set favorable conditions for a dormant, low pH-dependent (acidic) nuclease, which c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851eb7da554449313f2b0d90b204cf1f
https://doi.org/10.1038/sj.cdd.4400495
https://doi.org/10.1038/sj.cdd.4400495
Autor:
Malcolm C. Paterson
Publikováno v:
Annals of Saudi Medicine. 16:243-248
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c443166ed9dab3e77e763292d3b8b708
https://doi.org/10.5144/0256-4947.1996.243
https://doi.org/10.5144/0256-4947.1996.243
Publikováno v:
Carcinogenesis. 17:691-698
Dermal fibroblast strains cultured from affected members of a cancer-prone family with Li-Fraumeni syndrome (LFS) harbor a point mutation in one allele of the p53 tumor suppressor gene, resulting in loss of normal p53 function. In this study we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1993e4cb1599f7d90015af72dee0ea55
https://doi.org/10.1093/carcin/17.4.691
https://doi.org/10.1093/carcin/17.4.691
Publikováno v:
Genes, Chromosomes and Cancer. 14:63-67
The human retinoblastoma cell line Y79 has multiple copies of the MYCN gene and the DEAD box gene DDXI. Both genes have been mapped to chromosome band 2p24. A third gene, encoding the alpha-subunit of mitochondrial ATP synthase (ATPSA), is also ampli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12d55b0a62527819fbc4b21f5097761
https://doi.org/10.1002/gcc.2870140111
https://doi.org/10.1002/gcc.2870140111
Autor:
Esther Sook Miin Wong, Gavin S. Dawe, Oleg N. Demidov, Tan Chee Kuan, Malcolm C. Paterson, Francesca Fernandez, Deng Hong Min, Irene Soon, Zhi-Cheng Xiao, Zeng Li, Dmitry V. Bulavin
Dendritic spine morphology is modulated by protein kinase p38, a mitogen-activated protein (MAPK), in the hippocampus. Protein p38MAPK is a substrate of wip1, a protein phosphatase. The role of wip1 in the central nervous system (CNS) has never been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a132f472cca9bcfa7a619356f02acd
https://acuresearchbank.acu.edu.au/item/876v0/wip1-phosphatase-positively-modulates-dendritic-spine-morphology-and-memory-processes-through-the-p38mapk-signaling-pathway
https://acuresearchbank.acu.edu.au/item/876v0/wip1-phosphatase-positively-modulates-dendritic-spine-morphology-and-memory-processes-through-the-p38mapk-signaling-pathway
Publikováno v:
Mutation Research/DNA Repair. 314:99-113
O6-Methylguanine (m6G) is an altered base produced in DNA by SN1 methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). This lesion is repaired by the protein O6-methylguanine-DNA methyltransferase (MGMT) in normal human cell lines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9722264f4c8a98d4c2399380efac7728
https://doi.org/10.1016/0921-8777(94)90074-4
https://doi.org/10.1016/0921-8777(94)90074-4