Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Malcolm B Lowry"'
1
Akademický článek
Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ
Autor: Yang Zhang, Gerd Bobe, Cristobal L Miranda, Malcolm B Lowry, Victor L Hsu, Christiane V Lohr, Carmen P Wong, Donald B Jump, Matthew M Robinson, Thomas J Sharpton, Claudia S Maier, Jan F Stevens, Adrian F Gombart
Publikováno v: eLife, Vol 10 (2021)
We previously reported xanthohumol (XN), and its synthetic derivative tetrahydro-XN (TXN), attenuates high-fat diet (HFD)-induced obesity and metabolic syndrome in C57Bl/6J mice. The objective of the current study was to determine the effect of XN an
Externí odkaz: https://doaj.org/article/2429acd383fb4e10be829a3c44468c2f
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2
Akademický článek
The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older Adults: A Double-Blind, Randomized, Controlled Trial
Autor: Mary L. Fantacone, Malcolm B. Lowry, Sandra L. Uesugi, Alexander J. Michels, Jaewoo Choi, Scott W. Leonard, Sean K. Gombart, Jeffrey S. Gombart, Gerd Bobe, Adrian F. Gombart
Publikováno v: Nutrients, Vol 12, Iss 8, p 2447 (2020)
Older adults are at increased risk for vitamin and mineral deficiencies that contribute to age-related immune system decline. Several lines of evidence suggest that taking a multi-vitamin and mineral supplement (MVM) could improve immune function in
Externí odkaz: https://doaj.org/article/ada92fbcf9a4461886b4fe219ceb7205
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3
Akademický článek
Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia
Autor: Isabelle E. Logan, Gerd Bobe, Cristobal L. Miranda, Stephany Vasquez-Perez, Jaewoo Choi, Malcolm B. Lowry, Thomas J. Sharpton, Andrey Morgun, Claudia S. Maier, Jan F. Stevens, Natalia Shulzhenko, Adrian F. Gombart
Publikováno v: Microorganisms, Vol 8, Iss 4, p 520 (2020)
A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. To test the hypothesi
Externí odkaz: https://doaj.org/article/178af5bf71a84aa290ad54d28a43a9f7
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4
Akademický článek
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines
Autor: Isabelle E. Logan, Cristobal L. Miranda, Malcolm B. Lowry, Claudia S. Maier, Jan F. Stevens, Adrian F. Gombart
Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 5, p 1203 (2019)
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises concerns as gut microbiota and the host’s hepatic cytochrome P450 enzymes metabolize it into the most potent phytoest
Externí odkaz: https://doaj.org/article/b85f3fc0900642f3a5224aa65f316a37
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6
Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia
Autor: Malcolm B. Lowry, Thomas J. Sharpton, Cristobal L. Miranda, Claudia S. Maier, Jan F. Stevens, Andrey Morgun, Adrian F. Gombart, Stephany Vasquez-Perez, Isabelle E. Logan, Natalia Shulzhenko, Gerd Bobe, Jaewoo Choi
Publikováno v: Microorganisms
Volume 8
Issue 4
Microorganisms, Vol 8, Iss 520, p 520 (2020)
A calorie-dense diet is a well-established risk factor for obesity and metabolic syndrome (MetS), whereas the role of the intestinal microbiota (IMB) in the development of diet-induced obesity (DIO) is not completely understood. To test the hypothesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f95702a9065efed02c7fdea439a168
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7
A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression
Autor: Yang Zhang, Arup K. Indra, Gitali Ganguli-Indra, Yan Campbell, Malcolm B. Lowry, H. Phillip Koeffler, Weijian Zhang, Chunxiao Guo, Adrian F. Gombart, Richard L. Gallo, Mai Le, Isabelle E. Logan, Jingwei Xie, Mary L. Fantacone
Publikováno v: J Steroid Biochem Mol Biol
In humans and other primates, 1,25(OH)(2)vitamin D3 regulates the expression of the cathelicidin antimicrobial peptide (CAMP) gene via toll-like receptor (TLR) signaling that activates the vitamin D pathway. Mice and other mammals lack the vitamin D
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e923b3d8b2946e414a4c3742b3555c4f
https://europepmc.org/articles/PMC7089838/
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9
Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism
Autor: Jan F. Stevens, Claudia S. Maier, Paul R. Blakemore, Cristobal L. Miranda, Andrey Morgun, Thomas J. Sharpton, Richard R. Rodrigues, Johana S Revel, Kareem Raslan, Malcolm B. Lowry, Mary L. Fantacone, Yang Zhang, Adrian F. Gombart, Natalia Shulzhenko, Gerd Bobe
Publikováno v: Mol Nutr Food Res
SCOPE: We previously showed that two hydrogenated xanthohumol (XN) derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), improved parameters of metabolic syndrome (MetS), a critical risk factor of cardiovascular disease (CVD) and type 2 diabet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc950c4b35cbbc9e011a3a6440a2a05c
https://pubmed.ncbi.nlm.nih.gov/31755244
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10
Antiproliferative and Cytotoxic Activity of Xanthohumol and Its Non-Estrogenic Derivatives in Colon and Hepatocellular Carcinoma Cell Lines
Autor: Claudia S. Maier, Adrian F. Gombart, Malcolm B. Lowry, Cristobal L. Miranda, Jan F. Stevens, Isabelle E. Logan
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 5, p 1203 (2019)
Xanthohumol (XN), a prenylated flavonoid found in hops, inhibits growth in a variety of cancer cell lines; however, its use raises concerns as gut microbiota and the host’s hepatic cytochrome P450 enzymes metabolize it into the most potent phytoest
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2424e97155122c33719b6d913595dc56
http://europepmc.org/articles/PMC6429097
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