Výsledky vyhledávání - "Malcolm A S Moore"

Akademický článek

Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping.

Autor: Hans Zoellner, Belal Chami, Elizabeth Kelly, Malcolm A S Moore

Publikováno v: PLoS ONE, Vol 14, Iss 11, p e0224800 (2019)

We recently described a hydrodynamic mechanism for cytoplasmic transfer between cells, termed cell-projection pumping (CPP). Earlier image analysis related altered SAOS-2 osteosarcoma cell morphology, to what we now recognize as CPP uptake of fibrobl

Externí odkaz: https://doaj.org/article/27bdb5f80ea34c4fbdab1a9a15dd3b6a

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Akademický článek

UMG Lenti: novel lentiviral vectors for efficient transgene- and reporter gene expression in human early hematopoietic progenitors.

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114795 (2014)

Lentiviral vectors are widely used to investigate the biological properties of regulatory proteins and/or of leukaemia-associated oncogenes by stably enforcing their expression in hematopoietic stem and progenitor cells. In these studies it is critic

Externí odkaz: https://doaj.org/article/64d22681c17e4a2883751908468098d9

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Akademický článek

SAOS-2 osteosarcoma cells bind fibroblasts via ICAM-1 and this is increased by tumour necrosis factor-α.

Autor: Manu S David, Elizabeth Kelly, Ivan Cheung, Munira Xaymardan, Malcolm A S Moore, Hans Zoellner

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e101202 (2014)

We recently reported exchange of membrane and cytoplasmic markers between SAOS-2 osteosarcoma cells and human gingival fibroblasts (h-GF) without comparable exchange of nuclear markers, while similar h-GF exchange was seen for melanoma and ovarian ca

Externí odkaz: https://doaj.org/article/afca828bca644b7489b4c011b2fd1bf1

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Akademický článek

Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma.

Autor: Emil Lou, Sho Fujisawa, Alexei Morozov, Afsar Barlas, Yevgeniy Romin, Yildirim Dogan, Sepideh Gholami, André L Moreira, Katia Manova-Todorova, Malcolm A S Moore

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33093 (2012)

Tunneling nanotubes are long, non-adherent F-actin-based cytoplasmic extensions which connect proximal or distant cells and facilitate intercellular transfer. The identification of nanotubes has been limited to cell lines, and their role in cancer re

Externí odkaz: https://doaj.org/article/7ef94fc94a9e4b128b4193da820d765e

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Akademický článek

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment.

Autor: Xiaomin Zheng, Claudia Oancea, Reinhard Henschler, Malcolm A S Moore, Martin Ruthardt

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7661 (2009)

BACKGROUND:t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome--Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid l

Externí odkaz: https://doaj.org/article/7786b50bf61240549ce8b95f23bfd62c

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A Novel Cartesian Plot Analysis for Fixed Monolayers That Relates Cell Phenotype to Transfer of Contents between Fibroblasts and Cancer Cells by Cell-Projection Pumping

Autor: Swarna Mahadevan, Kenelm Kwong, Mingjie Lu, Elizabeth Kelly, Belal Chami, Yevgeniy Romin, Sho Fujisawa, Katia Manova, Malcolm A. S. Moore, Hans Zoellner

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 14; Pages: 7949

We recently described cell-projection pumping as a mechanism transferring cytoplasm between cells. The uptake of fibroblast cytoplasm by co-cultured SAOS-2 osteosarcoma cells changes SAOS-2 morphology and increases cell migration and proliferation, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038430dfb6fb3f72886b0e150d285d9c
https://pubmed.ncbi.nlm.nih.gov/35887295

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Intercellular Communication in Malignant Pleural Mesothelioma: Properties of Tunneling Nanotubes

Autor: Justin William Ady, Snider eDesir, Venugopal eThayanithy, Rachel Isaksson Vogel, André L. Moreira, Robert John Downey, Yuman eFong, Katia eManova-Todorova, Malcolm A. S. Moore, Emil eLou

Publikováno v: Frontiers in Physiology, Vol 5 (2014)
Frontiers in Physiology

Malignant pleural mesothelioma is a particularly aggressive and locally invasive malignancy with a poor prognosis despite advances in understanding of cancer cell biology and development of new therapies. At the cellular level, cultured mesothelioma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a751ecc09a6785f069e3df33f7e73e
http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00400/full

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Dendritic cells and macrophages can mature independently from a human bone marrow-derived, post-colony-forming unit intermediate

Autor: David Avigan, James W. Young, Stuart Gezelter, Ralph M. Steinman, Paul Szabolcs, David H. Ciocon, Malcolm A. S. Moore

Publikováno v: Blood. 87:4520-4530

CD34+ precursors in normal human bone marrow (BM) generate large numbers of dendritic cells alongside macrophages and granulocytic precursors when cultured for 12 to 14 days in c-kit ligand, granulocyte- macrophage colony-stimulating factor (GM-CSF),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02f1edebf1c3115bb48f1d81c39a081a
https://doi.org/10.1182/blood.v87.11.4520.bloodjournal87114520

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