Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Malcolm A Leissring"'
Autor:
Caitlin N Suire, Sarah Nainar, Michael Fazio, Adam G Kreutzer, Tara Paymozd-Yazdi, Caitlyn L Topper, Caroline R Thompson, Malcolm A Leissring
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193101 (2018)
Insulin-degrading enzyme (IDE) is an atypical zinc-metalloendopeptidase that hydrolyzes insulin and other intermediate-sized peptide hormones, many of which are implicated in skin health and wound healing. Pharmacological inhibitors of IDE administer
Externí odkaz:
https://doaj.org/article/c9bacd82d9a24f8b81a04be777941d36
Autor:
Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined th
Externí odkaz:
https://doaj.org/article/c8e7a6b3cbd440008791292cdd23c305
Autor:
Malcolm A Leissring
Publikováno v:
Frontiers in Aging Neuroscience, Vol 6 (2014)
Externí odkaz:
https://doaj.org/article/c8c357c561d44fee9f108e028c14bdaa
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20818 (2011)
Insulin-degrading enzyme (IDE) is widely recognized as the principal protease responsible for the clearance and inactivation of insulin, but its role in glycemic control in vivo is poorly understood. We present here the first longitudinal characteriz
Externí odkaz:
https://doaj.org/article/81c8d227c7f6478d900967920fda2a55
Autor:
Malcolm A Leissring, Enrico Malito, Sabrine Hedouin, Lael Reinstatler, Tomoko Sahara, Samer O Abdul-Hay, Shakeel Choudhry, Ghulam M Maharvi, Abdul H Fauq, Malwina Huzarska, Philip S May, Sungwoon Choi, Todd P Logan, Benjamin E Turk, Lewis C Cantley, Marika Manolopoulou, Wei-Jen Tang, Ross L Stein, Gregory D Cuny, Dennis J Selkoe
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10504 (2010)
Insulin is a vital peptide hormone that is a central regulator of glucose homeostasis, and impairments in insulin signaling cause diabetes mellitus. In principle, it should be possible to enhance the activity of insulin by inhibiting its catabolism,
Externí odkaz:
https://doaj.org/article/7240b4ca7af64bf1b6cd154a5b3c1c60
Autor:
Christelle Cabrol, Malwina A Huzarska, Christopher Dinolfo, Maria C Rodriguez, Lael Reinstatler, Jake Ni, Li-An Yeh, Gregory D Cuny, Ross L Stein, Dennis J Selkoe, Malcolm A Leissring
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5274 (2009)
Hypocatabolism of the amyloid beta-protein (Abeta) by insulin-degrading enzyme (IDE) is implicated in the pathogenesis of Alzheimer disease (AD), making pharmacological activation of IDE an attractive therapeutic strategy. However, it has not been es
Externí odkaz:
https://doaj.org/article/3c0395d5378b40ea8c72e4367da7ac27
Autor:
Heather M. Terron, Derek S. Maranan, Luke A. Burgard, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6745 (2023)
Commonly employed methods for reversibly disrupting gene expression, such as those based on RNAi or CRISPRi, are rarely capable of achieving >80–90% downregulation, making them unsuitable for targeting genes that require more complete disruption to
Externí odkaz:
https://doaj.org/article/0d0397e39d2b49f09eb1370c0a6f6828
Autor:
Malcolm A. Leissring
Publikováno v:
Cells, Vol 10, Iss 9, p 2445 (2021)
More than seven decades have passed since the discovery of a proteolytic activity within crude tissue extracts that would become known as insulin-degrading enzyme (IDE). Certainly much has been learned about this atypical zinc-metallopeptidase; at th
Externí odkaz:
https://doaj.org/article/8b7816130385469ea55377f757ee2e79
Autor:
Carlos M. González-Casimiro, Patricia Cámara-Torres, Beatriz Merino, Sergio Diez-Hermano, Tamara Postigo-Casado, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo
Publikováno v:
Cells, Vol 10, Iss 9, p 2446 (2021)
Insulin-degrading enzyme (IDE) is a highly conserved and ubiquitously expressed Zn2+-metallopeptidase that regulates hepatic insulin sensitivity, albeit its regulation in response to the fasting-to-postprandial transition is poorly understood. In thi
Externí odkaz:
https://doaj.org/article/c6f270047e4e485495d8abea55f99a06
Autor:
Beatriz Merino, Elena Casanueva-Álvarez, Iván Quesada, Carlos M. González-Casimiro, Cristina M. Fernández-Díaz, Tamara Postigo-Casado, Malcolm A. Leissring, Klaus H. Kaestner, Germán Perdomo, Irene Cózar-Castellano
Publikováno v:
UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname
Diabetologia, vol 65, iss 8
Digital.CSIC. Repositorio Institucional del CSIC
instname
Diabetologia, vol 65, iss 8
Digital.CSIC. Repositorio Institucional del CSIC
Producción Científica
Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understoo
Aims/hypothesis Type 2 diabetes is characterised by hyperglucagonaemia and perturbed function of pancreatic glucagon secreting alpha cells but the molecular mechanisms contributing to these phenotypes are poorly understoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d090b0ea2cf7a094fd5a8927bf5fad4
https://doi.org/10.1007/s00125-022-05729-y
https://doi.org/10.1007/s00125-022-05729-y