Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Malcolm A, Martin"'
Autor:
Joana Dias, Giulia Fabozzi, Slim Fourati, Xuejun Chen, Cuiping Liu, David R. Ambrozak, Amy Ransier, Farida Laboune, Jianfei Hu, Wei Shi, Kylie March, Anna A. Maximova, Stephen D. Schmidt, Jakob Samsel, Chloe A. Talana, Keenan Ernste, Sung Hee Ko, Margaret E. Lucas, Pierce E. Radecki, Kristin L. Boswell, Yoshiaki Nishimura, John-Paul Todd, Malcolm A. Martin, Constantinos Petrovas, Eli A. Boritz, Nicole A. Doria-Rose, Daniel C. Douek, Rafick-Pierre Sékaly, Jeffrey D. Lifson, Mangaiarkarasi Asokan, Lucio Gama, John R. Mascola, Amarendra Pegu, Richard A. Koup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Anti-HIV-1 broadly neutralizing antibodies (bNAbs) have the dual potential of mediating virus neutralization and antiviral effector functions through their Fab and Fc domains, respectively. So far, bNAbs with enhanced Fc effector functions i
Externí odkaz:
https://doaj.org/article/bf19edfc45874c86ab18e09d0df26155
Autor:
Zhi Yang, Kim-Marie A. Dam, Michael D. Bridges, Magnus A. G. Hoffmann, Andrew T. DeLaitsch, Harry B. Gristick, Amelia Escolano, Rajeev Gautam, Malcolm A. Martin, Michel C. Nussenzweig, Wayne L. Hubbell, Pamela J. Bjorkman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Neutralizing antibodies (bNAbs) against HIV-1 are exclusively directed against the viral envelope protein (Env) and mainly target Env in a closed, prefusion state. Here, Yang et al. structurally characterize two heterologously-neutralizing CD4-bindin
Externí odkaz:
https://doaj.org/article/a3f529a3512548c399bdcaadfab62202
Autor:
Morgan E. Abernathy, Harry B. Gristick, Jost Vielmetter, Jennifer R. Keeffe, Priyanthi N. P. Gnanapragasam, Yu E. Lee, Amelia Escolano, Rajeev Gautam, Michael S. Seaman, Malcolm A. Martin, Michel C. Nussenzweig, Pamela J. Bjorkman
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target ant
Externí odkaz:
https://doaj.org/article/dc207aad5e0148e593ea440eea90a943
Autor:
Harry B. Gristick, Harald Hartweger, Maximilian Loewe, Jelle van Schooten, Victor Ramos, Thiago Y. Oliveira, Yoshiaki Nishimura, Nicholas S. Koranda, Abigail Wall, Kai-Hui Yao, Daniel Poston, Anna Gazumyan, Marie Wiatr, Marcel Horning, Jennifer R. Keeffe, Magnus A. G. Hoffmann, Zhi Yang, Morgan E. Abernathy, Kim-Marie A. Dam, Han Gao, Priyanthi N. P. Gnanapragasam, Leesa M. Kakutani, Ana Jimena Pavlovitch-Bedzyk, Michael S. Seaman, Mark Howarth, Andrew T. McGuire, Leonidas Stamatatos, Malcolm A. Martin, Anthony P. West, Michel C. Nussenzweig, Pamela J. Bjorkman
Passive transfer of broadly neutralizing anti–HIV-1 antibodies (bNAbs) protects against infection, and therefore, eliciting bNAbs by vaccination is a major goal of HIV-1 vaccine efforts. bNAbs that target the CD4 binding site (CD4bs) on HIV-1 Env a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdfea6435d8275600e0a5a354868641
Autor:
Michel C. Nussenzweig, Malcolm A. Martin, Mila Jankovic, Amelia Escolano, Kai-Hui Yao, Fabian Schmidt, Yoshiaki Nishimura, Rajeev Gautam, Harald Hartweger
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::746702b4c6d5dab5fd1350ab3c6756bd
https://doi.org/10.3791/64858
https://doi.org/10.3791/64858
Autor:
Kshitij Wagh, Michael S Seaman, Marshall Zingg, Tomas Fitzsimons, Dan H Barouch, Dennis R Burton, Mark Connors, David D Ho, John R Mascola, Michel C Nussenzweig, Jeffrey Ravetch, Rajeev Gautam, Malcolm A Martin, David C Montefiori, Bette Korber
Publikováno v:
PLoS Pathogens, Vol 14, Iss 3, p e1006860 (2018)
There is great interest in passive transfer of broadly neutralizing antibodies (bnAbs) and engineered bispecific antibodies (Abs) for prevention of HIV-1 infections due to their in vitro neutralization breadth and potency against global isolates and
Externí odkaz:
https://doaj.org/article/bca8ddfb348642039e1f1555504bc829
Autor:
Jost Vielmetter, Michel C. Nussenzweig, Jennifer R. Keeffe, Priyanthi N. P. Gnanapragasam, Rajeev Gautam, Michael S. Seaman, Pamela J. Bjorkman, Amelia Escolano, Malcolm A. Martin, Morgan E. Abernathy, Yu E. Lee, Harry B. Gristick
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
NPJ Vaccines
NPJ Vaccines
HIV-1 vaccine design aims to develop an immunogen that elicits broadly neutralizing antibodies against a desired epitope, while eliminating responses to off-target regions of HIV-1 Env. We report characterization of Ab1245, an off-target antibody aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b965d4decbe92e214e5d17e9fcd1aa8d
https://doaj.org/article/dc207aad5e0148e593ea440eea90a943
https://doaj.org/article/dc207aad5e0148e593ea440eea90a943
Autor:
Nicole A Doria-Rose, Han R Altae-Tran, Ryan S Roark, Stephen D Schmidt, Matthew S Sutton, Mark K Louder, Gwo-Yu Chuang, Robert T Bailer, Valerie Cortez, Rui Kong, Krisha McKee, Sijy O'Dell, Felicia Wang, Salim S Abdool Karim, James M Binley, Mark Connors, Barton F Haynes, Malcolm A Martin, David C Montefiori, Lynn Morris, Julie Overbaugh, Peter D Kwong, John R Mascola, Ivelin S Georgiev
Publikováno v:
PLoS Pathogens, Vol 13, Iss 1, p e1006148 (2017)
Computational neutralization fingerprinting, NFP, is an efficient and accurate method for predicting the epitope specificities of polyclonal antibody responses to HIV-1 infection. Here, we present next-generation NFP algorithms that substantially imp
Externí odkaz:
https://doaj.org/article/8a81c72949514c31829e9f7bf5c3f8b9
Autor:
Andrew T. DeLaitsch, Nicholas Koranda, Murillo Silva, Han Gao, Leesa M. Kakutani, Amelia Escolano, Morgan E. Abernathy, Melissa Cipolla, Priyanthi N. P. Gnanapragasam, Thiago Y. Oliveira, Zhi Yang, Christopher O. Barnes, Jennifer R. Keeffe, Malcolm A. Martin, Zijun Wang, Michel C. Nussenzweig, Michael S. Seaman, Ana Gazumyan, Henna Raina, Darrell J. Irvine, Rajeev Gautam, Haoqing Wang, Pamela J. Bjorkman, Victor A. Ramos, Magnus A.G. Hoffmann, Anthony P. West, Harry B. Gristick, Yoshiaki Nishimura
Publikováno v:
Sci Transl Med
Broadly neutralizing antibodies (bNAbs) against HIV-1 develop after prolonged virus and antibody co-evolution. Previous studies showed that sequential immunization with a V3-glycan-patch germline-targeting HIV-1 envelope trimer (Env) followed by vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccd03a11a1f95bb633c87e9a2975f7d
https://resolver.caltech.edu/CaltechAUTHORS:20211124-195820111
https://resolver.caltech.edu/CaltechAUTHORS:20211124-195820111
Autor:
Zhi, Yang, Kim-Marie A, Dam, Michael D, Bridges, Magnus A G, Hoffmann, Andrew T, DeLaitsch, Harry B, Gristick, Amelia, Escolano, Rajeev, Gautam, Malcolm A, Martin, Michel C, Nussenzweig, Wayne L, Hubbell, Pamela J, Bjorkman
Publikováno v:
Nature communications. 13(1)
Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) antibodies, isolated from sequentially-immunized macaques. Ab1303/Ab1573 bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83a470073d9f0024e6db1b68a65f9eec
https://pubmed.ncbi.nlm.nih.gov/35136084
https://pubmed.ncbi.nlm.nih.gov/35136084