Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Malcolm, Maccoss"'
Autor:
Alastair D. G. Lawson, Malcolm MacCoss, Dominique L. Baeten, Alex Macpherson, Jiye Shi, Alistair J. Henry
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Over the last 10 years considerable progress has been made in the application of small molecules to modulating protein-protein interactions (PPIs), and the navigation from “undruggable” to a host of candidate molecules in clinical trials has been
Externí odkaz:
https://doaj.org/article/55d3049b08ac473c93e38790581f0e57
Autor:
Martin A. Lowe, Alvaro Cardenas, Jean-Pierre Valentin, Zhaoning Zhu, Jan Abendroth, Jose L. Castro, Reiner Class, Annie Delaunois, Renaud Fleurance, Helga Gerets, Vitalina Gryshkova, Lloyd King, Donald D. Lorimer, Malcolm MacCoss, Julian H. Rowley, Marie-Luce Rosseels, Leandro Royer, Richard D. Taylor, Melanie Wong, Oliver Zaccheo, Vishal P. Chavan, Gokul A. Ghule, Bapusaheb K. Tapkir, Jeremy N. Burrows, Maëlle Duffey, Matthias Rottmann, Sergio Wittlin, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Josefine Striepen, Kate J. Fairhurst, Tomas Yeo, David A. Fidock, Alan F. Cowman, Paola Favuzza, Benigno Crespo-Fernandez, Francisco Javier Gamo, Daniel E. Goldberg, Dominique Soldati-Favre, Benoît Laleu, Teresa de Haro
Publikováno v:
Journal of Medicinal Chemistry. 65:14121-14143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec94f8ff9ea22504d996591d0d9a232d
https://doi.org/10.1021/acs.jmedchem.2c01336
https://doi.org/10.1021/acs.jmedchem.2c01336
Publikováno v:
Journal of medicinal chemistry. 65(13)
We present a comprehensive analysis of all ring systems (both heterocyclic and nonheterocyclic) in clinical trial compounds and FDA-approved drugs. We show 67% of small molecules in clinical trials comprise only ring systems found in marketed drugs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23900d745a91787bb1f42d731c0484d5
https://pubmed.ncbi.nlm.nih.gov/35730680
https://pubmed.ncbi.nlm.nih.gov/35730680
Autor:
Alistair James Henry, Malcolm MacCoss, Dominique Baeten, Jiye Shi, Alex Macpherson, Alastair D. G. Lawson
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Frontiers in chemistry, 9:668186. Frontiers Media S.A.
Frontiers in Chemistry
Frontiers in chemistry, 9:668186. Frontiers Media S.A.
Frontiers in Chemistry
Over the last 10 years considerable progress has been made in the application of small molecules to modulating protein-protein interactions (PPIs), and the navigation from “undruggable” to a host of candidate molecules in clinical trials has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8f676380aa3cdf7da474d95501a0c4
https://www.frontiersin.org/articles/10.3389/fchem.2021.668186/full
https://www.frontiersin.org/articles/10.3389/fchem.2021.668186/full
Publikováno v:
Journal of Medicinal Chemistry. 61:4283-4289
Tackling PPIs, particularly by stabilizing clinically favored conformations of target proteins, with orally available, bona fide small molecules remains a significant but immensely worthwhile challenge for the pharmaceutical industry. Success may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c00bab84e54842168a6928749f513af
https://doi.org/10.1021/acs.jmedchem.7b01120
https://doi.org/10.1021/acs.jmedchem.7b01120
Autor:
Timothy W. Gorman, Benedicte Lallemand, Malcolm MacCoss, Michael C. Willis, Christopher J. Schofield, José L. Castro, Alistair J. M. Farley, Darren J. Dixon, Martin D. Smith, Bryony L. Elbert, Tarn C. Johnson, Jakub Flasz, Christophe Genicot, Robert S. Paton, Patrick Pasau
Publikováno v:
Chemical Science. 9(3)
Sulfones feature prominently in biologically active molecules and are key functional groups for organic synthesis. We report a mild, photoredox-catalyzed reaction for sulfonylation of aniline derivatives with sulfinate salts, and demonstrate the util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27ec42762c5cef363b2b4cc0470f697
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Journal of medicinal chemistry. 61(10)
Tackling PPIs, particularly by stabilizing clinically favored conformations of target proteins, with orally available, bona fide small molecules remains a significant but immensely worthwhile challenge for the pharmaceutical industry. Success may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29f23ef9c2e24df77fafe7f3a1693aa5
https://pubmed.ncbi.nlm.nih.gov/29140691
https://pubmed.ncbi.nlm.nih.gov/29140691
Publikováno v:
Journal of Medicinal Chemistry. 57:5845-5859
We have analyzed the rings, ring systems, and frameworks in drugs listed in the FDA Orange Book to understand the frequency, timelines, molecular property space, and the application of these rings in different therapeutic areas and target classes. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79eb946647b2df2bedf91b17b8bb5ec7
https://doi.org/10.1021/jm4017625
https://doi.org/10.1021/jm4017625
Publikováno v:
Journal of medicinal chemistry. 60(5)
We have enumerated all linear combinations of ring systems from FDA approved drugs, up to three rings in length and up to four bonds linkers to give an in silico database of approximately 14 million molecules. This virtual library was compared with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::681849c8a449646f9e879199a3a0561e
https://pubmed.ncbi.nlm.nih.gov/27935308
https://pubmed.ncbi.nlm.nih.gov/27935308
Autor:
Jeremy Clark, Xiao Tong, Ashok Arasappan, Randall R. Rossman, Anita T. Fowler, Subramaniam Ananthan, Vinay Girijavallabhan, Feng Geng, Regina Huelgas, Neng-Yang Shih, F. George Njoroge, Hollis S. Kezar, Joseph A. Maddry, Yuhua Huang, Frank Bennett, Cheng Li, John J. Piwinski, Cecil D. Kwong, John A. Secrist, Stephanie Curry, Abhijit Roychowdhury, Malcolm MacCoss, Robert C. Reynolds, Hsueh-Cheng Huang, Robert Chase
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5144-5149
Introduction of nitrogen atom into the benzene ring of a previously identified HCV replication (replicase) benzofuran inhibitor 2, resulted in the discovery of the more potent pyridofuran analogue 5. Subsequent introduction of small alkyl and alkoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19a20c57978b9eb8444e2b3affa03ce
https://doi.org/10.1016/j.bmcl.2012.06.021
https://doi.org/10.1016/j.bmcl.2012.06.021