Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Malayannan Subramaniam"'
Autor:
Kirsten G. M. Aspros, Michael J. Emch, Xiyin Wang, Malayannan Subramaniam, Megan L. Hinkle, Esther P. B. Rodman, Matthew P. Goetz, John R. Hawse
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Triple negative breast cancer (TNBC) is an aggressive sub-type of the disease which accounts for a disproportionately high percentage of breast cancer morbidities and mortalities. For these reasons, a better understanding of TNBC biology is required
Externí odkaz:
https://doaj.org/article/02caffd096eb485c9156f9741c54c9a7
Autor:
Kirsten G. M. Aspros, Jodi M. Carter, Tanya L. Hoskin, Vera J. Suman, Malayannan Subramaniam, Michael J. Emch, Zhenqing Ye, Zhifu Sun, Jason P. Sinnwell, Kevin J. Thompson, Xiaojia Tang, Esther P. B. Rodman, Xiyin Wang, Adam W. Nelson, Igor Chernukhin, Feda H. Hamdan, Elizabeth S. Bruinsma, Jason S. Carroll, Martin E. Fernandez-Zapico, Steven A. Johnsen, Krishna R. Kalari, Haojie Huang, Roberto A. Leon-Ferre, Fergus J. Couch, James N. Ingle, Matthew P. Goetz, John R. Hawse
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-15 (2022)
Abstract Triple Negative Breast Cancer (TNBC) accounts for 15–20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast cancer mortalities. Thus, there is an urgent need to identify novel biomarkers and t
Externí odkaz:
https://doaj.org/article/cb14a3f8cc2f47efa372c800d589e31a
Autor:
Anthony A Ruberto, Aline Gréchez-Cassiau, Sophie Guérin, Luc Martin, Johana S Revel, Mohamed Mehiri, Malayannan Subramaniam, Franck Delaunay, Michèle Teboul
Publikováno v:
eLife, Vol 10 (2021)
The mammalian circadian timing system and metabolism are highly interconnected, and disruption of this coupling is associated with negative health outcomes. Krüppel-like factors (KLFs) are transcription factors that govern metabolic homeostasis in v
Externí odkaz:
https://doaj.org/article/fa08fc0906c94393808804c0ab741b9b
Autor:
Nadine Baroukh, Nathan Canteleux, Antoine Lefèvre, Camille Dupuy, Cécile Martias, Antoine Presset, Malayannan Subramaniam, John R. Hawse, Patrick Emond, Philippe Pouletaut, Sandrine Morandat, Sabine F. Bensamoun, Lydie Nadal-Desbarats
Publikováno v:
Metabolites, Vol 12, Iss 6, p 556 (2022)
The transcription factor Krüppel-like factor 10 (Klf10), also known as Tieg1 for TGFβ (Inducible Early Gene-1) is known to control numerous genes in many cell types that are involved in various key biological processes (differentiation, proliferati
Externí odkaz:
https://doaj.org/article/df3452c8521d491aae4c8884357bf112
Autor:
Shivani N Mann, Niran Hadad, Molly Nelson Holte, Alicia R Rothman, Roshini Sathiaseelan, Samim Ali Mondal, Martin-Paul Agbaga, Archana Unnikrishnan, Malayannan Subramaniam, John Hawse, Derek M Huffman, Willard M Freeman, Michael B Stout
Publikováno v:
eLife, Vol 9 (2020)
Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves me
Externí odkaz:
https://doaj.org/article/1b1546f66bc7437c80062d0bfab7f142
Autor:
Malek Kammoun, Philippe Pouletaut, Francis Canon, Malayannan Subramaniam, John R Hawse, Muriel Vayssade, Sabine F Bensamoun
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164566 (2016)
As transforming growth factor (TGF)-β inducible early gene-1 is highly expressed in skeletal muscle, the effect of TIEG1 gene deletion on the passive mechanical properties of slow and fast twitch muscle fibers was analyzed. Twenty five muscle fibers
Externí odkaz:
https://doaj.org/article/9fbb1389d691447a8fc2534465ae4127
Autor:
Anne Gingery, Malayannan Subramaniam, Kevin S Pitel, Jordan M Reese, Muzaffer Cicek, Laurence B Lindenmaier, James N Ingle, Matthew P Goetz, Russell T Turner, Urszula T Iwaniec, Thomas C Spelsberg, John R Hawse
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98219 (2014)
Endoxifen has recently been identified as the predominant active metabolite of tamoxifen and is currently being developed as a novel hormonal therapy for the treatment of endocrine sensitive breast cancer. Based on past studies in breast cancer cells
Externí odkaz:
https://doaj.org/article/67822f0f26c34e9d85cce6b81062378a
Autor:
John R Hawse, Malayannan Subramaniam, Muzaffer Cicek, Xianglin Wu, Anne Gingery, Sarah B Grygo, Zhifu Sun, Kevin S Pitel, Wilma L Lingle, Matthew P Goetz, James N Ingle, Thomas C Spelsberg
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54613 (2013)
Endoxifen, a cytochrome P450 mediated tamoxifen metabolite, is being developed as a drug for the treatment of estrogen receptor (ER) positive breast cancer. Endoxifen is known to be a potent anti-estrogen and its mechanisms of action are still being
Externí odkaz:
https://doaj.org/article/53b65588edee4aa2a677eafd0d4587e4
Autor:
John R Hawse, Muzaffer Cicek, Sarah B Grygo, Elizabeth S Bruinsma, Nalini M Rajamannan, Andre J van Wijnen, Jane B Lian, Gary S Stein, Merry Jo Oursler, Malayannan Subramaniam, Thomas C Spelsberg
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19429 (2011)
Deletion of TIEG1/KLF10 in mice results in a gender specific osteopenic skeletal phenotype with significant defects in both cortical and trabecular bone, which are observed only in female animals. Calvarial osteoblasts isolated from TIEG1 knockout (K
Externí odkaz:
https://doaj.org/article/c3b2d29944cd4ce390182c32fdb11d6f
Autor:
Muzaffer Cicek, Anne Vrabel, Catherine Sturchio, Larry Pederson, John R Hawse, Malayannan Subramaniam, Thomas C Spelsberg, Merry Jo Oursler
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17522 (2011)
TGF-β Inducible Early Gene-1 (TIEG1) is a Krüppel-like transcription factor (KLF10) that was originally cloned from human osteoblasts as an early response gene to TGF-β treatment. As reported previously, TIEG1(-/-) mice have decreased cortical bon
Externí odkaz:
https://doaj.org/article/08f87d151b71472e8234f49a058e9ead