Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Malay, Mody"'
Autor:
Sunita Shankar, Jean Ching-Yi Tien, Ronald F. Siebenaler, Seema Chugh, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Xiao-Ming Wang, Ingrid J. Apel, Jessica Waninger, Sanjana Eyunni, Alice Xu, Malay Mody, Andrew Goodrum, Yuping Zhang, John J. Tesmer, Rahul Mannan, Xuhong Cao, Pankaj Vats, Sethuramasundaram Pitchiaya, Stephanie J. Ellison, Jiaqi Shi, Chandan Kumar-Sinha, Howard C. Crawford, Arul M. Chinnaiyan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Argonaute 2 (AGO2) binds RAS and is required for cellular transformation. Here, the authors establish a KRAS-driven mouse model of pancreatic cancer with conditional loss of AGO2 and show that the early phase of neoplastic lesion initiation is depend
Externí odkaz:
https://doaj.org/article/4879439f815846169a9d5e62cae6d7c2
Autor:
Malay Mody, Kyle J. Gontjes
Publikováno v:
American Journal of Infection Control. 51:466-468
Autor:
Ronald F, Siebenaler, Seema, Chugh, Jessica J, Waninger, Vijaya L, Dommeti, Carson, Kenum, Malay, Mody, Anudeeta, Gautam, Nidhi, Patel, Alec, Chu, Pushpinder, Bawa, Jennifer, Hon, Richard D, Smith, Heather, Carlson, Xuhong, Cao, John J G, Tesmer, Sunita, Shankar, Arul M, Chinnaiyan
Publikováno v:
PNAS nexus. 1(3)
Activating mutations in RAS GTPases drive nearly 30% of all human cancers. Our prior work described an essential role for Argonaute 2 (AGO2), of the RNA-induced silencing complex, in mutant
Autor:
Ronald F. Siebenaler, Jean Ching-Yi Tien, Vijaya L. Dommeti, Rahul Mannan, Stephanie J. Ellison, Sethuramasundaram Pitchiaya, Xuhong Cao, Seema Chugh, Howard C. Crawford, Ingrid J. Apel, Jessica Waninger, Chandan Kumar-Sinha, Andrew Goodrum, Sanjana Eyunni, Sylvia Zelenka-Wang, Pankaj Vats, Yuping Zhang, Malay Mody, Jiaqi Shi, Xiaoming Wang, Alice Xu, Sunita Shankar, John J.G. Tesmer, Arul M. Chinnaiyan
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Both KRAS and EGFR are essential mediators of pancreatic cancer development and interact with Argonaute 2 (AGO2) to perturb its function. Here, in a mouse model of mutant KRAS-driven pancreatic cancer, loss of AGO2 allows precursor lesion (PanIN) for
Autor:
Ronald F. Siebenaler, Sylvia Zelenka-Wang, Malay Mody, Vijaya L. Dommeti, Sunita Shankar, Arul M. Chinnaiyan, Jean C. Tien, Jessica Waninger, Chandan Kumar-Sinha, Seema Chugh
Publikováno v:
Molecular Cancer Research. 18:A21-A21
The RAS gene family is among the most commonly mutated genes within cancer, but little progress has been made in successfully targeting RAS mutations. Targeting binding partners of mutated RAS, however, presents a promising alternative therapeutic st
Autor:
Ronald F. Siebenaler, Jean Tien, Heather A. Carlson, Vijaya L. Dommeti, Richard D. Smith, Arul M. Chinnaiyan, Jessica Waninger, Malay Mody, Chandan Kumar-Sinha, John J.G. Tesmer, Tyler S. Beyett, Sunita Shankar
Publikováno v:
Molecular Cancer Research. 18:B39-B39
KRAS is one of three members of the RAS family of small GTPases, and nearly one third of all human cancers harbor mutations in the KRAS gene. These mutations lead to a constitutively active GTP-bound form of KRAS that results in aberrant activation o
Autor:
Jiaqi Shi, Andrew Goodrum, Vijaya L. Dommeti, John J.G. Tesmer, Alice Xu, Kristin M. Juckette, Sunita Shankar, Arul M. Chinnaiyan, Sanjana Eyunni, Xiaoming Wang, Malay Mody, Ronald F. Siebenaler, Yuping Zhang, Javed Siddiqui, Sylvia Zelenka-Wang, Grace Tsaloff, Jean Ching-Yi Tien, Xuhong Cao, Ingrid J. Apel, Richard D. Smith, Jessica Waninger, Chandan Kumar-Sinha, Lisha Wang, Seema Chugh, Heather A. Carlson
Publikováno v:
Molecular Cancer Research. 18:A20-A20
In 2016, we identified a direct interaction between RAS and Argonaute 2 (AGO2), a key mediator of RNA-mediated gene silencing that is required for KRAS-driven oncogenesis using pancreatic and lung cancer cell line models. Recently, we employed the ge
Autor:
Javed Siddiqui, Xiaoming Wang, Jiaqi Shi, Heather A. Carlson, Lisha Wang, Vijaya L. Dommeti, Ingrid J. Apel, Alice Xu, Seema Chugh, Grace Tsaloff, Sunita Shankar, Richard D. Smith, Sylvia Zelenka-Wang, John J.G. Tesmer, Jessica Waninger, Chandan Kumar-Sinha, Arul M. Chinnaiyan, Ronald F. Siebenaler, Andrew Goodrum, Howard C. Crawford, Sanjana Eyunni, Malay Mody, Kristin M. Juckette, Yuping Zhang, Jean Ching-Yi Tien, Xuhong Cao
KRAS and EGFR are known essential mediators of pancreatic cancer development. In addition, KRAS and EGFR have both been shown to interact with and perturb the function of Argonaute 2 (AGO2), a key regulator of RNA-mediated gene silencing. Here, we em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5649be3de14cf951f45f862dd09e6875
Autor:
Heather A. Carlson, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Seema Chugh, Sanjana Eyunni, Malay Mody, Kristin M. Juckette, Ingrid J. Apel, Grace Tsaloff, Jiaqi Shi, Alice Xu, Arul M. Chinnaiyan, Richard D. Smith, John J.G. Tesmer, Jessica Waninger, Chandan Kumar-Sinha, Ronald F. Siebenaler, Xiaoming Wang, Andrew Goodrum, Javed Siddiqui, Jean Ching-Yi Tien, Xuhong Cao, Sunita Shankar, Yuping Zhang
Publikováno v:
Cancer Research. 79:957-957
In 2016, we identified a direct interaction between RAS and Argonaute 2 (AGO2), a key mediator of RNA-mediated gene silencing, that is essential for KRAS-driven oncogenesis using pancreatic and lung cancer cell line models. Recently, we employed a ge
Autor:
Ronald F. Siebenaler, Sunita Shankar, Jean C. Tien, Vijaya L. Dommeti, Sylvia Zelenka-Wang, Seema Chugh, Ingrid J. Apel, Malay Mody, Anudeeta Gautam, Chandan Kumar-Sinha, Arul M. Chinnaiyan
Publikováno v:
Cancer Research. 79:956-956
The RAS gene family is among the most commonly mutated genes within cancer, but little progress has been made in successfully targeting RAS mutations. Targeting binding partners of mutated RAS presents as a promising alternative therapeutic strategy.