DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness.

Autor: Malavasi ELV; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Economides KD; Xtuit Pharmaceuticals, Waltham, MA, USA., Grünewald E; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Makedonopoulou P; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Gautier P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Mackie S; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Murphy LC; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Murdoch H; Molecular Pharmacology Group, Wolfson Building, Institute of Neuroscience and Psychology, The University of Glasgow, University Avenue, Glasgow, UK., Crummie D; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Ogawa F; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., McCartney DL; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., O'Sullivan ST; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Burr K; Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK., Torrance HS; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Phillips J; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Bonneau M; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Anderson SM; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Perry P; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Pearson M; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Constantinides C; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Davidson-Smith H; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Kabiri M; Translational In Vivo Models at Sanofi, Frankfurt, Germany., Duff B; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Johnstone M; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK.; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Polites HG; Regeneron Pharmaceuticals, Tarrytown NY, USA., Lawrie SM; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Blackwood DH; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Semple CA; MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Evans KL; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Didier M; Translational Sciences at Sanofi, Chilly-Mazarin, France., Chandran S; Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK., McIntosh AM; Division of Psychiatry, The University of Edinburgh, Edinburgh, UK., Price DJ; Centre for Integrative Physiology, The University of Edinburgh, Edinburgh, UK., Houslay MD; School of Cancer and Pharmaceutical Sciences, King's College London, London, UK., Porteous DJ; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK., Millar JK; Centre for Genomic and Experimental Medicine, MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh, Edinburgh, UK. kirsty.millar@igmm.ed.ac.uk.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2018 Sep 06; Vol. 8 (1), pp. 184. Date of Electronic Publication: 2018 Sep 06.