Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Malathy Sony Subramanian, Manimekalai"'
Autor:
Chui Fann Wong, Joon Shin, Malathy Sony Subramanian Manimekalai, Wuan Geok Saw, Zhan Yin, Shashi Bhushan, Arvind Kumar, Priya Ragunathan, Gerhard Grüber
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Despite the highly oxidative environment of the phagosomal lumen, the need for maintaining redox homeostasis is a critical aspect of mycobacterial biology. The pathogens are equipped with the sophisticated thioredoxin- (Trx) and peroxiredoxi
Externí odkaz:
https://doaj.org/article/abe170557c194602b72f09980a0259f7
Autor:
Gerhard Grüber, Roderick W. Bates, Thomas Dick, Liam K. Harold, Jickky Palmae Sarathy, Malathy Sony Subramanian Manimekalai, Shi Min Sherilyn Chong, Gregory M. Cook, Zoe C. Williams, Kevin Pethe
Publikováno v:
ACS Infectious Diseases. 6:725-737
The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of Mycobacterium tuberculosis, which causes tuberculosis. By employing a lead repurposing strategy, the malarial cytochro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e36cfcb770a0514e35648c28def660f
https://doi.org/10.1021/acsinfecdis.9b00408
https://doi.org/10.1021/acsinfecdis.9b00408
Autor:
Ambrish Kumar, Sierin Lim, Bhargy Sharma, Konstantin Pervushin, Siu Kwan Sze, Sunil S. Adav, Margaret Phillips, Bhuvaneswari Kannaian, Gerhard Grüber, Justin Tze Yang Ng, Anup Chowdhury, Malathy Sony Subramanian Manimekalai, Yuguang Mu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports
Scientific Reports
Misfolding of Amyloid β (Aβ) peptides leads to the formation of extracellular amyloid plaques. Molecular chaperones can facilitate the refolding or degradation of such misfolded proteins. Here, for the first time, we report the unique ability of Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2f4b9fb692cd351c47f4516751ffbb
http://link.springer.com/article/10.1038/s41598-019-48819-5
http://link.springer.com/article/10.1038/s41598-019-48819-5
Autor:
Raphael Bieri, Marcel Tanner, Aurélie Chauffour, Nitin Pal Kalia, Garrett C. Moraski, Marvin J. Miller, Matthias Witschel, Gerhard Grüber, Norihisa Ishii, Sangeeta Susan Thomas, Nicole Scherr, Araceli Lamelas, Kevin Pethe, Paul Schneide, Vincent Jarlier, Marie-Thérèse Ruf, Malathy Sony Subramanian Manimekalai, Koichi Suzuki, Gerd Pluschke
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5370. ⟨10.1038/s41467-018-07804-8⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5370. ⟨10.1038/s41467-018-07804-8⟩
Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are limited to antibioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c1548b7d9fc78e7bdeacb39a510502
http://link.springer.com/article/10.1038/s41467-018-07804-8
http://link.springer.com/article/10.1038/s41467-018-07804-8
Autor:
Malcolm S. Cole, Wassihun Wedajo Aragaw, Pooja Hegde, Malathy Sony Subramanian Manimekalai, Gerhard Grüber, Sankaranarayanan Rishikesan, Courtney C. Aldrich, Thomas Dick, Chitra Latka, Joon Shin, Priya Ragunathan
Publikováno v:
ACS Chem Biol
A common strategy employed in antibacterial drug discovery is targeting of biosynthetic processes which are essential and specific for the pathogen. Specificity in particular avoids undesirable interactions with potential enzymatic counterparts in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b173510492b1b0653a33e24175a77660
https://europepmc.org/articles/PMC8217388/
https://europepmc.org/articles/PMC8217388/
Autor:
Priya Ragunathan, Joon Shin, Ming Wei Chen, Gerhard Grüber, Bharti Singal, Malathy Sony Subramanian Manimekalai
The stringent response, regulated by the bifunctional (p)ppGpp synthetase/hydrolase Rel in mycobacteria, is critical for long-term survival of the drug-tolerant dormant state of Mycobacterium tuberculosis. During amino acid starvation, MtRel senses a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10180a877095d1074f838957c473b0bc
https://hdl.handle.net/10356/154271
https://hdl.handle.net/10356/154271
Autor:
Sylvie Alonso, John Chan, Ekaterina N. Sviriaeva, Gerhard Grüber, Marvin J. Miller, Garrett C. Moraski, Vanessa Hui Qi Koh, Michael Berney, Jiayong Xu, Bei Shi Lee, Malathy Sony Subramanian Manimekalai, Dirk Schnappinger, Jared S. Mackenzie, Curtis A. Engelhart, Adrie J. C. Steyn, Kiel Hards, Kevin Pethe, Sherilyn Shi Min Chong, Erik J. Hasenoehrl, Nitin Pal Kalia, Gregory M. Cook
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
EMBO Molecular Medicine, Vol 13, Iss 1, Pp n/a-n/a (2021)
The approval of bedaquiline has placed energy metabolism in the limelight as an attractive target space for tuberculosis antibiotic development. While bedaquiline inhibits the mycobacterial F1F0 ATP synthase, small molecules targeting other component
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be61bb23a16a2d5337b93d0307834cf
https://doi.org/10.15252/emmm.202013207
https://doi.org/10.15252/emmm.202013207
Publikováno v:
ACS infectious diseases. 6(7)
Cytochrome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9412e54eb3b5c9388614d3ccd4b01e9
https://pubmed.ncbi.nlm.nih.gov/32379966
https://pubmed.ncbi.nlm.nih.gov/32379966
Autor:
Shi Min Sherilyn, Chong, Malathy Sony Subramanian, Manimekalai, Jickky Palmae, Sarathy, Zoe C, Williams, Liam K, Harold, Gregory M, Cook, Thomas, Dick, Kevin, Pethe, Roderick W, Bates, Gerhard, Grüber
Publikováno v:
ACS infectious diseases. 6(4)
The ability to respire and generate adenosine triphosphate (ATP) is essential for the physiology, persistence, and pathogenicity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13393ca5d33a49d59e87050af227046d
https://pubmed.ncbi.nlm.nih.gov/32092260
https://pubmed.ncbi.nlm.nih.gov/32092260
Cytochrome bd (cyt-bd) oxygen reductases have a high affinity to oxygen and use the two electrons provided by ubiquinol or menaquinol, like in mycobacteria, to reduce oxygen to water. Although they do not pump protons from the cytoplasmic to the peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff759b2196e04c37440adf72a327bdc
https://hdl.handle.net/10356/149230
https://hdl.handle.net/10356/149230