Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Malathi Chellappan"'
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114698 (2014)
Mesenchymal stem/stromal cells respond to physical cues present in their microenvironment such as substrate elasticity, geometry, or topography with respect to morphology, proliferation, and differentiation. Although studies have demonstrated the rol
Externí odkaz:
https://doaj.org/article/d62175a867bf481f9dff6848d22c7221
Autor:
Nicolas Christoforou, Malathi Chellappan, Andrew F Adler, Robert D Kirkton, Tianyi Wu, Russell C Addis, Nenad Bursac, Kam W Leong
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63577 (2013)
Transient overexpression of defined combinations of master regulator genes can effectively induce cellular reprogramming: the acquisition of an alternative predicted phenotype from a differentiated cell lineage. This can be of particular importance i
Externí odkaz:
https://doaj.org/article/36961434f43a4058af0d11d6d51700d2
Autor:
Timothy E. Reddy, Joshua B. Black, Alexias Safi, Lingyun Song, Isaac B. Hilton, Malathi Chellappan, Gregory E. Crawford, Tyler S. Klann, Charles A. Gersbach
Publikováno v:
Nature biotechnology
Large genome-mapping consortia and thousands of genome-wide association studies have identified non-protein-coding elements in the genome as having a central role in various biological processes. However, decoding the functions of the millions of put
Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models
Autor:
Christopher L. Grigsby, Kam W. Leong, Yvonne Yamanaka, Yihua Loo, Malathi Chellappan, Hai-Quan Mao, Xuan Jiang
Publikováno v:
Journal of Controlled Release. 160:48-56
Oral nonviral gene delivery is the most attractive and arguably the most challenging route of administration. To identify a suitable carrier, we studied the transport of different classes (natural polymer, synthetic polymer and synthetic lipid–poly
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 12, p e114698 (2014)
PLoS ONE, Vol 9, Iss 12, p e114698 (2014)
Mesenchymal stem/stromal cells respond to physical cues present in their microenvironment such as substrate elasticity, geometry, or topography with respect to morphology, proliferation, and differentiation. Although studies have demonstrated the rol
Autor:
Malathi Chellappan, Ryohei Yasuda, Ellen Hammett, Hong Wang, Karina Kulangara, Andrew F. Adler, Kam W. Leong
Publikováno v:
Biomaterials. 35(20)
Cellular reprogramming holds tremendous potential for cell therapy and regenerative medicine. Recently, fibroblasts have been directly converted into induced neurons (iNs) by overexpression of the neuronal transcription factors Ascl1, Brn2 and Myt1L.
Autor:
Tyler S. Klann, Ami M. Kabadi, Malathi Chellappan, Charles A. Gersbach, Timothy E. Reddy, Jennifer B. Kwon
Publikováno v:
Molecular Therapy. 24:S210
The advent of cellular reprogramming has introduced new possibilities for regenerative medicine, drug discovery, and controlling cellular behavior. Recent studies have identified many natural transcription factors that are capable of directing lineag