Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Malaney C. Young"'
Autor:
Nagamani Vunnam, Malaney C. Young, Elly E. Liao, Chih Hung Lo, Evan Huber, MaryJane Been, David D. Thomas, Jonathan N. Sachs
Publikováno v:
Cancer Biology & Therapy, Vol 24, Iss 1 (2023)
Nimesulide is a nonsteroidal anti-inflammatory drug and a COX-2 inhibitor with antitumor and antiproliferative activities that induces apoptosis in oral, esophagus, breast, and pancreatic cancer cells. Despite being removed from the market due to hep
Externí odkaz:
https://doaj.org/article/8339f8f393c04b4cb0e30efbbd4b2ad7
Autor:
Anthony R. Braun, Elly E. Liao, Mian Horvath, Prakriti Kalra, Karen Acosta, Malaney C. Young, Noah Nathan Kochen, Chih Hung Lo, Roland Brown, Michael D. Evans, William C. K. Pomerantz, Elizabeth Rhoades, Kelvin Luk, Razvan L. Cornea, David D. Thomas, Jonathan N. Sachs
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-17 (2021)
Abstract We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two
Externí odkaz:
https://doaj.org/article/ee6b8563f73c49f68804418a48d07270
Autor:
Malaney C. Young, Nagamani Vunnam, Robyn T. Rebbeck, Samantha L. Yuen, David D. Thomas, Jonathan N. Sachs
Publikováno v:
Natural Product Communications. 18:1934578X2211445
Death receptor 5 (DR5) is an apoptosis-inducing membrane receptor that mediates cell death in several life-threatening conditions. There is a crucial need for the discovery of DR5 antagonists for the therapeutic intervention of conditions in which th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77d7e9ab0f38e5e1a7ae211ae1b87267
https://doi.org/10.1177/1934578x221144580
https://doi.org/10.1177/1934578x221144580
Autor:
David D. Thomas, William C. K. Pomerantz, Prakriti Kalra, Michael D. Evans, Noah Nathan Kochen, Razvan L. Cornea, Mian Horvath, Jonathan N. Sachs, Chih Hung Lo, Roland Brown, Anthony R. Braun, Elly E. Liao, Kelvin C. Luk, Elizabeth Rhoades, Karen Acosta, Malaney C. Young
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-17 (2021)
NPJ Parkinson's Disease
NPJ Parkinson's Disease
We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two αSN FRET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab1e793565ee58566feda2e9040c41c
https://doi.org/10.1038/s41531-021-00195-6
https://doi.org/10.1038/s41531-021-00195-6
Autor:
Elly E. Liao, David D. Thomas, Chih Hung Lo, Mian Horvath, Michael D. Evans, Kelvin C. Luk, Jonathan N. Sachs, Roland Brown, Anthony R. Braun, Malaney C. Young
Preventing or reversing the pathological misfolding and self-association of alpha-synuclein (aSyn) can rescue a broad spectrum of pathological cellular insults that manifest in Parkinson’s Disease (PD), Dementia with Lewy bodies (DLB), and other al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab034dd024fb681ad79f7b98faaf228
