Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Malamati Kourti"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8630 (2024)
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, manifests through dysregulation of brain function and subsequent loss of bodily control, attributed to β-amyloid plaque deposition and TAU protein hyperphosphorylation and aggrega
Externí odkaz:
https://doaj.org/article/6be3fae4a8fc40a1943782db2386dc65
Autor:
Malamati Kourti, Athanasios Metaxas
Publikováno v:
Neurobiology of Disease, Vol 192, Iss , Pp 106427- (2024)
Transgenic models of familial Alzheimer's disease (AD) serve as valuable tools for probing the molecular mechanisms associated with amyloid-beta (Aβ)-induced pathology. In this meta-analysis, we sought to evaluate levels of phosphorylated tau (p-tau
Externí odkaz:
https://doaj.org/article/8989df26b78b446f90e6ba7d363262e7
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Characterized by a complex pathophysiology that includes the intraneuronal formation of neurofibrillary tangles and the extracellular deposition of β-amyloid plaques, Alzheimer’s disease (AD) is a terminal neurodegenerative disease that causes dem
Externí odkaz:
https://doaj.org/article/ef8f6ce66ded425ca7fae0e5c3a57192
Autor:
Evripides Iakovou, Malamati Kourti
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
IntroductionAging is a normal, inevitable, irreversible, and progressive process which is driven by internal and external factors. Oxidative stress, that is the imbalance between prooxidant and antioxidant molecules favoring the first, plays a key ro
Externí odkaz:
https://doaj.org/article/a44266d017a04a17838ae33841107eb9
Autor:
Ioanna Ioannou, Angeliki Chatziantoniou, Constantinos Drenios, Panayiota Christodoulou, Malamati Kourti, Apostolos Zaravinos
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6577 (2023)
There are several studies on the deregulated gene expression profiles in kidney cancer, with varying results depending on the tumor histology and other parameters. None of these, however, have identified the networks that the co-deregulated genes (co
Externí odkaz:
https://doaj.org/article/3fa4a6ab07f141968f62d777be83076c
Autor:
Thekla Theofanous, Malamati Kourti
Publikováno v:
Medicinal Chemistry. 18:772-783
Background: Reactive oxygen species (ROS) play a vital role in cell signaling when maintained at low concentrations. However, when ROS production exceeds the neutralizing capacity of endogenous antioxidants, oxidative stress is observed, which has be
Publikováno v:
Anticancer Research. 41:5881-5902
Cancer remains the second leading cause of death worldwide. Research is currently focused on finding novel anticancer therapies and elucidating their mechanisms of action. Cellular redox balance is a promising target for new therapies, as cancer cell
Autor:
Polyxeni Vafopoulou, Malamati Kourti
Publikováno v:
Journal of Cancer Metastasis and Treatment. 8:18
Cancer is a group of diseases with significant morbidity and mortality. In cancer cells, where energy requirements are exceptionally high, angiogenesis, which is the sprouting of new blood vessels from pre-existing ones, is an important process for t
Autor:
Andrea Brancale, Malamati Kourti, Andrew D. Westwell, Alessandra Cavaliere, Arwyn Tomos Jones, Noha I. Ziedan, Filippo Prencipe, Rania Hamdy
Publikováno v:
Chemical Biology & Drug Design. 90:147-155
A new series of oxadiazoles were designed to act as inhibitors of the anti-apoptotic Bcl-2\ud protein. Virtual screening led to the discovery of new hits that interact with Bcl-2 at the BH3\ud binding pocket. Further study of the structure-activity r
Publikováno v:
Medicinal chemistry (Shariqah (United Arab Emirates)). 17(1)
Purpose: Carbon monoxide-releasing molecules (CORMs) are a special class of organometallic complexes that have been reported to offer beneficial effects against different conditions including several subtypes of cancer. Especially for the aggressive