Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety in mice

Autor: Malalaniaina Rakotobe, Niels Fjerdingstad, Nuria Ruiz-Reig, Thomas Lamonerie, Fabien D'Autréaux

Publikováno v: Neurobiology of Disease, Vol 191, Iss , Pp 106392- (2024)

Having experienced stress during sensitive periods of brain development strongly influences how individuals cope with later stress. Some are prone to develop anxiety or depression, while others appear resilient. The as-yet-unknown mechanisms underlyi

Externí odkaz: https://doaj.org/article/ec026ddf2eb94e10b3dff37d170f9278

Role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to stress-induced anxiety

Autor: Malalaniaina Rakotobe, Niels Fjerdingstad, Nuria Ruiz-Reig, Thomas Lamonerie, Fabien D'Autréaux

Experiencing stress during sensitive periods of brain development has a major impact on how individuals cope with later stress. Although many become more prone to develop anxiety or depression, some appear resilient. The mechanisms underlying these d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12eeceeb786b62f3aef6a282f857390
https://doi.org/10.21203/rs.3.rs-823079/v3

Developmental Requirement of Homeoprotein Otx2 for Specific Habenulo-Interpeduncular Subcircuits

Autor: Thomas Lamonerie, Fabien D'Autréaux, Hannah-Isadora Huditz, Gwenaëlle Le Menn, Nuria Ruiz-Reig, Malalaniaina Rakotobe, Hélène Marie, Ingrid Bethus

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2019, 39 (6), pp.1005-1019. ⟨10.1523/JNEUROSCI.1818-18.2018⟩
Journal of Neuroscience, 2019, 39 (6), pp.1005-1019. ⟨10.1523/JNEUROSCI.1818-18.2018⟩

The habenulo-interpeduncular system (HIPS) is now recognized as a critical circuit modulating aversion, reward, and social behavior. There is evidence that dysfunction of this circuit leads to psychiatric disorders. Because psychiatric diseases may o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90982e13b8642bc69aca40337a146b8
https://hal.archives-ouvertes.fr/hal-02283269