Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice

Autor: Marco Corazzari, Laura Tapella, Giulia Dematteis, Carla Distasi, Ramunė Morkūnienė, Marcello Manfredi, Elettra Barberis, Federico Alessandro Ruffinatti, Mariagrazia Grilli, Elena Grossini, Serena Farruggio, Aistė Jekabsone, Dmitry Lim, Armando A. Genazzani, Eleonora Ferrari, Emilio Marengo, Malak Chahin, Gabrielė Vydmantaitė

Publikováno v: Cell Death & Disease, London : Nature Publishing Group, 2020, vol. 11, no. 8, 645, p. 1-6
Cell Death & Disease
Cell Death and Disease, Vol 11, Iss 8, Pp 1-16 (2020)

The pathogenesis of Alzheimer’s disease (AD), a slowly-developing age-related neurodegenerative disorder, is a result of the action of multiple factors including deregulation of Ca2+ homeostasis, mitochondrial dysfunction, and dysproteostasis. Inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1904eb430ea84b4e76d755d723461c5
https://doi.org/10.1038/s41419-020-02911-1