Zobrazeno 1 - 10
of 402
pro vyhledávání: '"Malachi Griffith"'
Autor:
My H. Hoang, Zachary L. Skidmore, Hans Rindt, Shirley Chu, Bryan Fisk, Jennifer A. Foltz, Catrina Fronick, Robert Fulton, Mingyi Zhou, Nathan J. Bivens, Carol N. Reinero, Todd A. Fehniger, Malachi Griffith, Jeffrey N. Bryan, Obi L. Griffith
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Spontaneous cancers in companion dogs are robust models of human disease. Tracking tumor-specific immune responses in these models requires reagents to perform species-specific single cell T cell receptor sequencing (scTCRseq). scTCRseq and
Externí odkaz:
https://doaj.org/article/5c2e989e11084889b89031b8e7093906
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-13 (2024)
Abstract Background Although macrophages are now recognized as an essential part of the HIV latent reservoir, whether and how viral latency is established and reactivated in these cell types is poorly understood. To understand the fundamental mechani
Externí odkaz:
https://doaj.org/article/8c94df1c588449a6bb188a9517454e3e
Autor:
Christopher J. Yoon, Chang Hyun Nam, Taewoo Kim, Jeong Seok Lee, Ryul Kim, Kijong Yi, June-Young Koh, Jiye Kim, Hyein Won, Ji Won Oh, Obi L. Griffith, Malachi Griffith, Joohon Sung, Tae Yeul Kim, Duck Cho, Ji Seon Choi, Young Seok Ju
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100301- (2024)
Summary: While most dizygotic twins have a dichorionic placenta, rare cases of dizygotic twins with a monochorionic placenta have been reported. The monochorionic placenta in dizygotic twins allows in utero exchange of embryonic cells, resulting in c
Externí odkaz:
https://doaj.org/article/f1dbbd925688474a9c7d70779040690e
Autor:
Arpad Danos, Kilannin Krysiak, Jason Saliba, Adam Coffman, Susanna Kiwala, Joshua McMichael, Cameron Grisdale, Mariam Khanfar, Malachi Griffith, Obi Griffith
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 100967- (2024)
Externí odkaz:
https://doaj.org/article/2910944566184b6d9df06e438ef1c2f6
Autor:
Deborah Ritter, Chansonette Badduke, Michael Anderson, Arpad Danos, Kurston Doonanco, Kirsten Farncombe, Bailey Gallinger, Rachel Giles, Malachi Griffith, Obi Griffith, Carolyn Horton, Kathleen Hruska, Hio Chung Kang, Kilannin Krysiak, Minjie Luo, Jerry Machado, Eamonn Maher, Kelly McGoldrick, Tina Pesaran, Neta Pipko, Sarah Ridd, Jason Saliba, Clare Sheen, Raymond Kim
Publikováno v:
Genetics in Medicine Open, Vol 2, Iss , Pp 100984- (2024)
Externí odkaz:
https://doaj.org/article/54780ae93b5543a2b43a555d9765c974
Autor:
Kelsy C. Cotto, Yang-Yang Feng, Avinash Ramu, Megan Richters, Sharon L. Freshour, Zachary L. Skidmore, Huiming Xia, Joshua F. McMichael, Jason Kunisaki, Katie M. Campbell, Timothy Hung-Po Chen, Emily B. Rozycki, Douglas Adkins, Siddhartha Devarakonda, Sumithra Sankararaman, Yiing Lin, William C. Chapman, Christopher A. Maher, Vivek Arora, Gavin P. Dunn, Ravindra Uppaluri, Ramaswamy Govindan, Obi L. Griffith, Malachi Griffith
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Analysing the regulatory consequences of mutations and splice variants at large scale in cancer requires efficient computational tools. Here, the authors develop RegTools, a software package that can identify splice-associated variants from large-sca
Externí odkaz:
https://doaj.org/article/a791b7f280e84d3d8c3cf984f3f564cd
Autor:
Sharon L. Freshour, Timothy H.-P. Chen, Bryan Fisk, Haolin Shen, Matthew Mosior, Zachary L. Skidmore, Catrina Fronick, Jennifer K. Bolzenius, Obi L. Griffith, Vivek K. Arora, Malachi Griffith
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107937- (2023)
Summary: To explore mechanisms of response to combined PD-1/CTLA-4 immune checkpoint blockade (ICB) treatment in individual cell types, we generated scRNA-seq using a mouse model of invasive urothelial carcinoma with three conditions: untreated tumor
Externí odkaz:
https://doaj.org/article/67fb9baedbd64cec8b29ce8c9afd80cf
Autor:
Pamela Wong, Jennifer A. Foltz, Lily Chang, Carly C. Neal, Tony Yao, Celia C. Cubitt, Jennifer Tran, Samantha Kersting-Schadek, Sathvik Palakurty, Natalia Jaeger, David A. Russler-Germain, Nancy D. Marin, Margery Gang, Julia A. Wagner, Alice Y. Zhou, Miriam T. Jacobs, Mark Foster, Timothy Schappe, Lynne Marsala, Ethan McClain, Patrick Pence, Michelle Becker-Hapak, Bryan Fisk, Allegra A. Petti, Obi L. Griffith, Malachi Griffith, Melissa M. Berrien-Elliott, Todd A. Fehniger
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 13 (2023)
Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear. To address this, T-BET and
Externí odkaz:
https://doaj.org/article/74062db604294ed99bc9e3922c1fadcb
Autor:
Jan Martinek, Ryan C Fields, Scott Gettinger, Karolina Palucka, Katerina Politi, Jun Zhao, Ye Bi, Richard A Flavell, Frank Detterbeck, Obi Griffith, Liang Shan, Malachi Griffith, Michael Chiorazzi, Bradley Krasnick, Yunjiang Zheng, Keenan J Robbins, Rihao Qu, Gabriel Kaufmann, Zachary Skidmore, Melani Juric, Laura A Henze, Frederic Brösecke, Adam Adonyi, Esen Sefik, Jacqueline Mudd, S Peter Goedegebuure, Abimbola Oyedeji, Sofia Fertuzinhos, Rolando Garcia-Milian, Daniel Boffa, Andrew Dhanasopon, Justin Blasberg, Benjamin Judson, Yuval Kluger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 7 (2023)
Background Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by interspecies differences between human and mouse, as
Externí odkaz:
https://doaj.org/article/9479165cf09946f8937b35f6027d8425
Autor:
Erica K. Barnell, Bryan Fisk, Zachary L. Skidmore, Kelsy C. Cotto, Anamika Basu, Aparna Anand, Megan M. Richters, Jingqin Luo, Catrina Fronick, Meenakshi Anurag, Robert Fulton, Matthew J. Ellis, Obi L. Griffith, Malachi Griffith, Foluso O. Ademuyiwa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Circulating tumor DNA (ctDNA) in peripheral blood has been used to predict prognosis and therapeutic response for triple-negative breast cancer (TNBC) patients. However, previous approaches typically use large comprehensive panels of genes c
Externí odkaz:
https://doaj.org/article/3af58d865b054925a0b3bd93aeb20f97